公开(公告)号：US5706805A

公开(公告)日：1998-01-13

申请号：US476566

申请日：1995-06-07

申请人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke Jian Liu ,  Karsten Mader

发明人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke Jian Liu ,  Karsten Mader

IPC分类号： G01R33/28 ,  A61B5/00 ,  A61B5/055 ,  G01N24/10 ,  G01R33/465 ,  G01R33/60 ,  A61B5/14

CPC分类号： A61B5/145 ,  A61B5/055 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  G01R33/465 ,  G01R33/60 ,  G01R33/281

摘要： The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological system and exposed to a magnetic field and an electromagnetic field in the 1-2 GHz range. The EPR spectra is then measured at the biological system to determine oxygen concentration. The EPR spectra is determined by an EPR spectrometer that adjusts the resonator to a single resonator frequency to compensate for movements of the biological system, such as a human or animal. The biological system can also include other in vivo tissues, cells, and cell cultures to directly measure pO.sub.2 non-destructively. The paramagnetic material can be used non-invasively or invasively depending on the goals of the pO2 measurement. A detecting inductive element, as part of the EPR spectrometer resonator, is adapted relative to the measurement particularities.

摘要翻译： 本发明提供了使用生理上可接受的顺磁性材料（例如印度墨水或炭黑）和电子顺磁共振（EPR）血氧测定法来测量生物系统中的氧张力的装置和方法。 印度墨水被引入生物系统并暴露于1-2GHz范围内的磁场和电磁场。 然后在生物系统中测量EPR光谱以测定氧浓度。 EPR光谱由EPR光谱仪测定，EPR光谱仪将谐振器调节到单个谐振器频率，以补偿生物系统（例如人或动物）的运动。 生物系统还可以包括其他体内组织，细胞和细胞培养物，以便非破坏性地直接测量pO2。 取决于pO2测量的目标，顺磁材料可以非侵入性或侵入性地使用。 作为EPR光谱仪谐振器的一部分的检测电感元件相对于测量特性被适配。

公开(公告)号：US5833601A

公开(公告)日：1998-11-10

申请号：US847794

申请日：1997-04-28

申请人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke Jian Liu

发明人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke Jian Liu

IPC分类号： G01R33/28 ,  A61B5/00 ,  A61B5/055 ,  G01N24/10 ,  G01R33/465 ,  G01R33/60

CPC分类号： A61B5/145 ,  A61B5/055 ,  A61B5/14542 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  G01R33/465 ,  G01R33/60 ,  G01R33/281

摘要： The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological system and exposed to a magnetic field and an electromagnetic field in the 1-2 GHz range. The EPR spectra is then measured at the biological system to determine oxygen concentration. The EPR spectra is determined by an EPR spectrometer that adjusts the resonator to a single resonator frequency to compensate for movements of the biological system, such as a human or animal. The biological system can also include other in vivo tissues, cells, and cell cultures to directly measure pO.sub.2 non-destructively.

摘要翻译： 本发明提供了使用生理上可接受的顺磁性材料（例如印度墨水或炭黑）和电子顺磁共振（EPR）血氧测定法来测量生物系统中的氧张力的装置和方法。 印度墨水被引入生物系统并暴露于1-2GHz范围内的磁场和电磁场。 然后在生物系统中测量EPR光谱以测定氧浓度。 EPR光谱由EPR光谱仪测定，EPR光谱仪将谐振器调节到单个谐振器频率，以补偿生物系统（例如人或动物）的运动。 生物系统还可以包括其他体内组织，细胞和细胞培养物，以便非破坏性地直接测量pO2。

公开(公告)号：US5494030A

公开(公告)日：1996-02-27

申请号：US105459

申请日：1993-08-12

申请人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke J. Liu

发明人： Harold M. Swartz ,  Fuminori Goda ,  Tadeusz Walczak ,  Ke J. Liu

IPC分类号： G01R33/28 ,  A61B5/00 ,  A61B5/055 ,  G01N24/10 ,  G01R33/465 ,  G01R33/60 ,  A61B5/14

CPC分类号： A61B5/145 ,  A61B5/055 ,  A61B5/14542 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  G01R33/465 ,  G01R33/60 ,  G01R33/281

摘要： The invention provides apparatus and methods for measuring oxygen tensions in biological systems utilizing physiologically acceptable paramagnetic material, such as India ink or carbon black, and electron paramagnetic resonance (EPR) oximetry. India ink is introduced to the biological system and exposed to a magnetic field and an electromagnetic field in the 1-2 GHz range. The EPR spectra is then measured at the biological system to determine oxygen concentration. The EPR spectra is determined by an EPR spectrometer that adjusts the resonator to a single resonator frequency to compensate for movements of the biological system, such as a human or animal. The biological system can also include other in vivo tissues, cells, and cell cultures to directly measure pO.sub.2 non-destructively.

摘要翻译： 本发明提供了使用生理上可接受的顺磁性材料（例如印度墨水或炭黑）和电子顺磁共振（EPR）血氧测定法来测量生物系统中的氧张力的装置和方法。 印度墨水被引入生物系统并暴露于1-2GHz范围内的磁场和电磁场。 然后在生物系统中测量EPR光谱以测定氧浓度。 EPR光谱由EPR光谱仪测定，EPR光谱仪将谐振器调节到单个谐振器频率，以补偿生物系统（例如人或动物）的运动。 生物系统还可以包括其他体内组织，细胞和细胞培养物，以便非破坏性地直接测量pO2。