-
1.发明申请Quinoxalinones and their use especially in the treatment of cardiovascular diseases 审中-公开喹喔啉酮及其用途特别用于治疗心血管疾病公开(公告)号：US20060247244A1
公开(公告)日：2006-11-02
申请号：US10503521
申请日：2003-01-27
申请人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
发明人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
IPC分类号： A61K31/498 , C07D241/36
CPC分类号： C07D403/12 , C07D241/44 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to quinoxalinones and to methods for producing the same as well as the use thereof for preparing drugs for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases.
摘要翻译： 本发明涉及喹喔啉酮及其制备方法以及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
-
公开(公告)号：US07498460B2
公开(公告)日：2009-03-03
申请号：US10537623
申请日：2003-11-28
申请人： Michael Härter , Jens Ergüden , Frank Wunder , Hanna Tinel , Johannes Köbberling , Eva-Maria Becker , Klaus Münter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Bärfacker , Walter Hübsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
发明人： Michael Härter , Jens Ergüden , Frank Wunder , Hanna Tinel , Johannes Köbberling , Eva-Maria Becker , Klaus Münter , Karl-Heinz Schlemmer , Raimund Kast , Peter Kolkhof , Gunter Karig , Lars Bärfacker , Walter Hübsch , Joachim Schuhmacher , Susanne Zuleger , Arnel Concepcion , Haruka Shimizu
IPC分类号： C07C229/10
CPC分类号： C07D319/08 , C07C235/60 , C07C235/62 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D205/04 , C07D211/34 , C07D211/60 , C07D211/62 , C07D307/58 , C07D317/54 , C07D317/62 , C07D319/06 , C07D405/12
摘要： The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
摘要翻译： 本发明涉及间苯二甲酸衍生物，其制备方法及其用于制备用于治疗和/或预防人和动物特别是心血管疾病疾病的药物。
-
3.发明授权公开(公告)号：US08329716B2
公开(公告)日：2012-12-11
申请号：US11547975
申请日：2005-03-30
申请人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
发明人： Hartmut Schirok , Martin Radtke , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Michael Thutewohl , Samir Bennabi , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to hetaryloxy-substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及苯甲酰氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
-
公开(公告)号：US07723347B2
公开(公告)日：2010-05-25
申请号：US11587630
申请日：2005-04-14
申请人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Münter , Marc Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
发明人： Hartmut Schirok , Johannes-Peter Stasch , Raimund Kast , Klaus Münter , Marc Jean Gnoth , Santiago Figureoa Perez , Michael Thutewohl , Samir Bennabi , Dieter Lang , Joachim Mittendorf , Martin Radtke , Heimo Ehmke
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to substituted phenylaminopyrimidines, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
-
5.发明授权Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂公开(公告)号：US07737153B2
公开(公告)日：2010-06-15
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
IPC分类号： A01N43/90 , A61K31/519 , A61K31/505 , C07D487/00 , C07D239/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译： 本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。 本发明化合物抑制Rho-激酶。
-
![Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same](/abs-image/US/2013/03/19/US08399471B2/abs.jpg.150x150.jpg)
6.发明授权Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same 有权芳基或杂芳基取代的吡啶并[2,3-d]嘧啶及其药物组合物公开(公告)号：US08399471B2
公开(公告)日：2013-03-19
申请号：US12303369
申请日：2007-05-25
申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
IPC分类号： C07D471/04 , A61K32/519 , A61P9/00
CPC分类号： C07D471/04
摘要： The present application relates to novel aryl- or heteroaryl-substitued pyrido[2,3-d] pyrimidines of formula (I), pharmaceuitical compositions of the same, and a process for their preparation. Formula(I) is: wherein Ar is an aryl or heteroaryl substituent, and R1, R2, R3, Ar, D, and E are as defined in the specification. Compounds and compositions of the present invention can be used in the treatment and/or prophylaxis of various disorders in humans and animals, including aldosteronism, high blood pressure, chronic heart failure, the sequelae of a myocardial infarction, cirrhosis of the liver, renal failure, and stroke.
摘要翻译： 本申请涉及式（I）的新型芳基或杂芳基取代的吡啶并[2,3-d]嘧啶，其药物组合物及其制备方法。 式（I）是：其中Ar是芳基或杂芳基取代基，R1，R2，R3，Ar，D和E如说明书中所定义。 本发明的化合物和组合物可用于治疗和/或预防人和动物的各种疾病，包括醛固酮增多症，高血压，慢性心力衰竭，心肌梗死的后遗症，肝硬化，肾衰竭 和中风。
-
7.发明申请5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS 有权5-ARYL取代的二氢吡啶并嘧啶和二羟基吡啶并将其用作矿物质抗坏血酸公开(公告)号：US20100035902A1
公开(公告)日：2010-02-11
申请号：US12303369
申请日：2007-05-25
申请人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
发明人： Santiago Figueroa Perez , Peter Kolkhof , Lars Bärfacker , Ingo Flamme , Karl-Heinz Schlemmer , Alexander Kuhl , Rolf Grosser , Klaus Münter , Andreas Knorr
IPC分类号： A61K31/519 , C07D471/04 , A61P9/10 , A61P9/12
CPC分类号： C07D471/04
摘要： The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的芳基取代的杂双环化合物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病尤其是心血管疾病的药物的用途 疾病
-
公开(公告)号：US07173037B2
公开(公告)日：2007-02-06
申请号：US10513869
申请日：2003-04-25
申请人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
发明人： Cristina Alonso-Alija , Erwin Bischoff , Klaus Münter , Johannes-Peter Stasch , Elke Stahl , Stefan Weigand , Achim Feurer
IPC分类号： C07D471/04 , A61K31/506 , C07D231/38
CPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.
摘要翻译： 本发明涉及刺激可溶性鸟苷酸环化酶，其制备及其作为药物的用途，特别是作为用于治疗心血管疾病和/或性功能障碍的药物的化合物。
-
9.发明授权Derivatives of 2-(1-benzyl-1H-pyrazolo(3,4-B)pyridine-3-yl)-5(-4-pyridinyl)l-4-pyrimidinamines and the use thereof as quanylate cyclase stimulators 有权2-（1-苄基-1H-吡唑并（3,4-B）吡啶-3-基）-5（-4-吡啶基）-1- [4-嘧啶胺]的衍生物及其作为苯甲酸酯环化酶刺激剂的用途公开(公告)号：US07135474B2
公开(公告)日：2006-11-14
申请号：US10514909
申请日：2003-05-05
IPC分类号： C07D471/04 , A61K31/505 , C07D231/38
CPC分类号： C07D471/04
摘要： This application relates to compounds of the formula (I) in which R1 is chlorine, cyano, trifluoromethyl or methoxy and R2 is hydrogen or flurorine; or R1 and R2 are both fluorine; and to pharmaceutically acceptable salts of these materials. Pharmaceutical compositions containing these materials, and methods of using them in treatment of hypertension and sexual dysfunction are also disclosed and claimed.
摘要翻译： 本申请涉及式（I）化合物，其中R 1是氯，氰基，三氟甲基或甲氧基，R 2是氢或氟磺酰; 或R 1和R 2均为氟; 以及这些材料的药学上可接受的盐。 还公开并要求保护含有这些材料的药物组合物和使用它们治疗高血压和性功能障碍的方法。
-
10.发明授权公开(公告)号：US08987256B2
公开(公告)日：2015-03-24
申请号：US12937995
申请日：2009-04-06
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
IPC分类号： A61K31/5395 , A61K31/502 , A61K31/4245 , A61K31/53 , C07D237/32 , C07D273/04 , C07D271/113 , C07D253/075 , C07D209/46 , C07D209/48 , C07D213/64 , C07D215/227 , C07D231/56 , C07D233/32 , C07D237/14 , C07D239/88 , C07D253/08 , C07D261/20 , C07D263/20 , C07D275/06 , C07D417/12 , A61K31/421 , A61K31/451 , A61K31/426 , C07D263/22 , C07D211/76 , C07D401/12 , C07D405/12 , C07D277/34 , A61P7/02 , A61P9/12 , A61P3/00 , A61P9/04 , A61P9/10
CPC分类号： C07D237/32 , C07D209/46 , C07D209/48 , C07D211/76 , C07D213/64 , C07D215/227 , C07D231/56 , C07D233/32 , C07D237/14 , C07D239/88 , C07D253/075 , C07D253/08 , C07D261/20 , C07D263/20 , C07D271/113 , C07D273/04 , C07D275/06 , C07D277/34 , C07D417/12
摘要： The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及具有氧代取代的氮杂环状部分结构的新型羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.041 秒)
