利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.027 秒)

    N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters
    3.
    发明授权
    N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters 失效
    N-烷基1,4-二羟基吡啶二羧酸酯

    公开(公告)号：US5234935A

    公开(公告)日：1993-08-10

    申请号：US680454

    申请日：1991-04-04

    申请人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    发明人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    IPC分类号： A61K31/445 ,  A61K31/44 ,  A61K31/451 ,  A61P9/08 ,  A61P9/10 ,  C07D211/90

    CPC分类号： C07D211/90

    摘要： Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl,R.sup.2 represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl or methyl,R.sup.3 represents hydrogen or cyano, orR.sup.2 and R.sup.3 together form a fused benzo ring,R.sup.4 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by alkoxy having up to 4 carbon atoms, andR.sup.6 represents straight-chain or branched alkyl having up to 10 carbon atoms or represents cycloalkyl having 3 to 7 carbon atoms.Many of the compounds are new.

    摘要翻译： 使用其中R 1表示氢，硝基，氰基，三氟甲基，三氟甲氧基，卤素或甲基的式（I）的N-烷基化1,4-二氢吡啶，改善循环，对血压影响最小，R 2表示氢， 卤素，硝基，羟基，三氟甲基或甲基，R 3表示氢或氰基，或R 2和R 3一起形成稠合的苯并环，R 4和R 5相同或不同，表示具有至多8个碳原子的直链或支链烷基， 任选被具有至多4个碳原子的烷氧基取代，R6代表具有至多10个碳原子的直链或支链烷基或代表具有3至7个碳原子的环烷基。 许多化合物是新的。

    Haemorheological use of N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters, and some new compounds
    4.
    发明授权
    Haemorheological use of N-alkylated 1,4-dihydropyridine-dicarboxylic acid esters, and some new compounds 失效
    N-烷基化1,4-二氢吡啶 - 二羧酸酯的血液流变学研究，以及一些新的化合物

    公开(公告)号：US5432185A

    公开(公告)日：1995-07-11

    申请号：US65503

    申请日：1993-05-21

    申请人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    发明人： Otto Behner ,  Hartmut Wollweber ,  Bruno Rosen ,  Siegfried Zaiss ,  Siegfried Goldmann

    IPC分类号： A61K31/445 ,  A61K31/44 ,  A61K31/451 ,  A61P9/08 ,  A61P9/10 ,  C07D211/90 ,  A61K31/455

    CPC分类号： C07D211/90

    摘要： Improving circulation, with minimal effect on blood pressure, using N-alkylated 1,4-dihydropyridines of the formula ##STR1## in which R.sup.1 represents hydrogen, nitro, cyano, trifluoromethyl, trifluoromethoxy, halogen or methyl,R.sup.2 represents hydrogen, halogen, nitro, hydroxyl, trifluoromethyl or methyl,R.sup.3 represents hydrogen or cyano, orR.sup.2 and R.sup.3 together form a fused benzo ring,R.sup.4 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by alkoxy having up to 4 carbon atoms, andR.sup.6 represents straight-chain or branched alkyl having up to 10 carbon atoms or represents cycloalkyl having 3 to 7 carbon atoms.Many of the compounds are new.

    摘要翻译： 使用其中R 1表示氢，硝基，氰基，三氟甲基，三氟甲氧基，卤素或甲基的式（I）的N-烷基化1,4-二氢吡啶，改善循环，对血压影响最小，R 2表示氢， 卤素，硝基，羟基，三氟甲基或甲基，R 3表示氢或氰基，或R 2和R 3一起形成稠合的苯并环，R 4和R 5相同或不同，表示具有至多8个碳原子的直链或支链烷基， 任选被具有至多4个碳原子的烷氧基取代，R6代表具有至多10个碳原子的直链或支链烷基或代表具有3至7个碳原子的环烷基。 许多化合物是新的。