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公开(公告)号:US20060205667A1
公开(公告)日:2006-09-14
申请号:US10528360
申请日:2003-09-19
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
CPC分类号: C07K14/47
摘要: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. Peptides which comprise an amino acid sequence of the formula: X—Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.
摘要翻译: 提供WT1的新型取代型肽,其中半胱氨酸残基被定义的氨基酸残基取代,编码所述肽的多核苷酸,在体内或体外使用那些肽或多核苷酸的癌症疫苗等。 包含下式的氨基酸序列的肽:XY-Thr-Trp-Asn-Gln-Met-Asn-Leu(SEQ ID NO:4),其中X表示Ser,Ala,Abu,Arg,Lys,Orn,Cit, Leu,Phe或Asn,Y表示Tyr或Met,并且其具有诱导CTL的活性,编码所述肽的多核苷酸,包含那些肽或多核苷酸作为活性成分的癌症疫苗等。
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公开(公告)号:US07378384B2
公开(公告)日:2008-05-27
申请号:US10528360
申请日:2003-09-19
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
CPC分类号: C07K14/47
摘要: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided.Peptides which comprise an amino acid sequence of the formula: X-Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.
摘要翻译: 提供WT1的新型取代型肽,其中半胱氨酸残基被定义的氨基酸残基取代,编码所述肽的多核苷酸,在体内或体外使用那些肽或多核苷酸的癌症疫苗等。 包含下式的氨基酸序列的肽:XY-Thr-Trp-Asn-Gln-Met-Asn-Leu(SEQ ID NO:4),其中X表示Ser,Ala,Abu,Arg,Lys,Orn,Cit, Leu,Phe或Asn,Y表示Tyr或Met,并且其具有诱导CTL的活性,编码所述肽的多核苷酸,包含那些肽或多核苷酸作为活性成分的癌症疫苗等。
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公开(公告)号:US20070082860A1
公开(公告)日:2007-04-12
申请号:US10517600
申请日:2003-06-12
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
CPC分类号: C07K7/06 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , C07K7/08 , C07K14/4748
摘要: HLA-A24-restricted peptides derived from WT1 which have an activity to induce CTLs in vivo, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. The cancer vaccines of the present invention may be used to treat many cancer patients.
摘要翻译: 提供了源自WT1的HLA-A24限制性肽,其具有在体内诱导CTL的活性,编码所述肽的多核苷酸,在体内或体外使用这些肽或多核苷酸的癌症疫苗等。 本发明的癌症疫苗可用于治疗许多癌症患者。
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公开(公告)号:US07666985B2
公开(公告)日:2010-02-23
申请号:US12142372
申请日:2008-06-19
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
CPC分类号: C07K7/06 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , C07K7/08 , C07K14/4748
摘要: HLA-A24-restricted peptides derived from WT1 which have an activity to induce CTLs in vivo, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. The cancer vaccines of the present invention may be used to treat many cancer patients.
摘要翻译: 提供了源自WT1的HLA-A24限制性肽,其具有在体内诱导CTL的活性,编码所述肽的多核苷酸,在体内或体外使用这些肽或多核苷酸的癌症疫苗等。 本发明的癌症疫苗可用于治疗许多癌症患者。
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公开(公告)号:US20090099090A1
公开(公告)日:2009-04-16
申请号:US12142372
申请日:2008-06-19
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
CPC分类号: C07K7/06 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , C07K7/08 , C07K14/4748
摘要: HLA-A24-restricted peptides derived from WT1 which have an activity to induce CTLs in vivo, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. The cancer vaccines of the present invention may be used to treat many cancer patients.
摘要翻译: 提供了源自WT1的HLA-A24限制性肽,其具有在体内诱导CTL的活性,编码所述肽的多核苷酸,在体内或体外使用这些肽或多核苷酸的癌症疫苗等。 本发明的癌症疫苗可用于治疗许多癌症患者。
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公开(公告)号:US07420034B2
公开(公告)日:2008-09-02
申请号:US10517600
申请日:2003-06-12
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu
IPC分类号: A61K38/00
CPC分类号: C07K7/06 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , C07K7/08 , C07K14/4748
摘要: HLA-A24-restricted peptides derived from WT1 which have an activity to induce CTLs in vivo, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. The cancer vaccines of the present invention may be used to treat many cancer patients.
摘要翻译: 提供了源自WT1的HLA-A24限制性肽,其具有在体内诱导CTL的活性,编码所述肽的多核苷酸,在体内或体外使用这些肽或多核苷酸的癌症疫苗等。 本发明的癌症疫苗可用于治疗许多癌症患者。
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公开(公告)号:US20100292164A1
公开(公告)日:2010-11-18
申请号:US12795187
申请日:2010-06-07
申请人: Haruo SUGIYAMA , Hideo Takasu , Fumio Samizo
发明人: Haruo SUGIYAMA , Hideo Takasu , Fumio Samizo
CPC分类号: C07K7/06
摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.
摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。
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公开(公告)号:US08242084B2
公开(公告)日:2012-08-14
申请号:US12795187
申请日:2010-06-07
申请人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
发明人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
IPC分类号: A61K38/00
CPC分类号: C07K7/06
摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.
摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。
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公开(公告)号:US20060217297A1
公开(公告)日:2006-09-28
申请号:US10541821
申请日:2004-01-15
申请人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
发明人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
CPC分类号: C07K7/06
摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.
摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。
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