Wt1 substitution pepides
    1.
    发明申请
    Wt1 substitution pepides 有权
    Wt1替代pepides

    公开(公告)号:US20060205667A1

    公开(公告)日:2006-09-14

    申请号:US10528360

    申请日:2003-09-19

    IPC分类号: A61K38/10 C07K7/08

    CPC分类号: C07K14/47

    摘要: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. Peptides which comprise an amino acid sequence of the formula: X—Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.

    摘要翻译: 提供WT1的新型取代型肽,其中半胱氨酸残基被定义的氨基酸残基取代,编码所述肽的多核苷酸,在体内或体外使用那些肽或多核苷酸的癌症疫苗等。 包含下式的氨基酸序列的肽:XY-Thr-Trp-Asn-Gln-Met-Asn-Leu(SEQ ID NO:4),其中X表示Ser,Ala,Abu,Arg,Lys,Orn,Cit, Leu,Phe或Asn,Y表示Tyr或Met,并且其具有诱导CTL的活性,编码所述肽的多核苷酸,包含那些肽或多核苷酸作为活性成分的癌症疫苗等。

    WT1 substitution peptides
    2.
    发明授权
    WT1 substitution peptides 有权
    WT1取代肽

    公开(公告)号:US07378384B2

    公开(公告)日:2008-05-27

    申请号:US10528360

    申请日:2003-09-19

    IPC分类号: A61K38/02 A61K38/08

    CPC分类号: C07K14/47

    摘要: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided.Peptides which comprise an amino acid sequence of the formula: X-Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.

    摘要翻译: 提供WT1的新型取代型肽,其中半胱氨酸残基被定义的氨基酸残基取代,编码所述肽的多核苷酸,在体内或体外使用那些肽或多核苷酸的癌症疫苗等。 包含下式的氨基酸序列的肽:XY-Thr-Trp-Asn-Gln-Met-Asn-Leu(SEQ ID NO:4),其中X表示Ser,Ala,Abu,Arg,Lys,Orn,Cit, Leu,Phe或Asn,Y表示Tyr或Met,并且其具有诱导CTL的活性,编码所述肽的多核苷酸,包含那些肽或多核苷酸作为活性成分的癌症疫苗等。

    DIMERIZED PEPTIDE
    7.
    发明申请
    DIMERIZED PEPTIDE 有权
    二聚体肽

    公开(公告)号:US20100292164A1

    公开(公告)日:2010-11-18

    申请号:US12795187

    申请日:2010-06-07

    IPC分类号: A61K38/16 C07K14/00 A61P35/00

    CPC分类号: C07K7/06

    摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.

    摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。

    Dimerized peptide
    8.
    发明授权
    Dimerized peptide 有权
    二聚肽

    公开(公告)号:US08242084B2

    公开(公告)日:2012-08-14

    申请号:US12795187

    申请日:2010-06-07

    IPC分类号: A61K38/00

    CPC分类号: C07K7/06

    摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.

    摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。

    Dimerized peptide
    9.
    发明申请
    Dimerized peptide 审中-公开
    二聚肽

    公开(公告)号:US20060217297A1

    公开(公告)日:2006-09-28

    申请号:US10541821

    申请日:2004-01-15

    IPC分类号: A61K38/17 A61K38/10

    CPC分类号: C07K7/06

    摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.

    摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。