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公开(公告)号:US20060205667A1
公开(公告)日:2006-09-14
申请号:US10528360
申请日:2003-09-19
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
CPC分类号: C07K14/47
摘要: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided. Peptides which comprise an amino acid sequence of the formula: X—Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.
摘要翻译: 提供WT1的新型取代型肽,其中半胱氨酸残基被定义的氨基酸残基取代,编码所述肽的多核苷酸,在体内或体外使用那些肽或多核苷酸的癌症疫苗等。 包含下式的氨基酸序列的肽:XY-Thr-Trp-Asn-Gln-Met-Asn-Leu(SEQ ID NO:4),其中X表示Ser,Ala,Abu,Arg,Lys,Orn,Cit, Leu,Phe或Asn,Y表示Tyr或Met,并且其具有诱导CTL的活性,编码所述肽的多核苷酸,包含那些肽或多核苷酸作为活性成分的癌症疫苗等。
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公开(公告)号:US08242084B2
公开(公告)日:2012-08-14
申请号:US12795187
申请日:2010-06-07
申请人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
发明人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
IPC分类号: A61K38/00
CPC分类号: C07K7/06
摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.
摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。
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公开(公告)号:US20060217297A1
公开(公告)日:2006-09-28
申请号:US10541821
申请日:2004-01-15
申请人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
发明人: Haruo Sugiyama , Hideo Takasu , Fumio Samizo
CPC分类号: C07K7/06
摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.
摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。
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公开(公告)号:US20100292164A1
公开(公告)日:2010-11-18
申请号:US12795187
申请日:2010-06-07
申请人: Haruo SUGIYAMA , Hideo Takasu , Fumio Samizo
发明人: Haruo SUGIYAMA , Hideo Takasu , Fumio Samizo
CPC分类号: C07K7/06
摘要: The present invention provides a novel tumor antigen peptide and its cancer vaccine, specifically, a peptide dimer wherein two peptide monomers consisting of 7-30 amino acids including at least one cysteine residue and being capable of producing a tumor antigen peptide are bound each other through a disulfide bond.
摘要翻译: 本发明提供了一种新的肿瘤抗原肽及其癌症疫苗,特别是肽二聚体,其中由包含至少一个半胱氨酸残基并能产生肿瘤抗原肽的7-30个氨基酸组成的两个肽单体通过 二硫键。
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公开(公告)号:US07378384B2
公开(公告)日:2008-05-27
申请号:US10528360
申请日:2003-09-19
申请人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
发明人: Haruo Sugiyama , Masashi Gotoh , Hideo Takasu , Fumio Samizo , Naoto Kusunose , Masashi Nakatsuka
CPC分类号: C07K14/47
摘要: Novel substituted type peptides of WT1 wherein the cysteine residue is substituted with a defined amino acid residue, polynucleotides encoding said peptides, cancer vaccines using those peptides or polynucleotides in vivo or in vitro, or the like are provided.Peptides which comprise an amino acid sequence of the formula: X-Y-Thr-Trp-Asn-Gln-Met-Asn-Leu (SEQ ID NO: 4) wherein X represents Ser, Ala, Abu, Arg, Lys, Orn, Cit, Leu, Phe, or Asn, and Y represents Tyr or Met, and which has an activity to induce CTLs, polynucleotides encoding said peptides, cancer vaccines which comprise those peptides or polynucleotides as an active ingredient, and the like are disclosed.
摘要翻译: 提供WT1的新型取代型肽,其中半胱氨酸残基被定义的氨基酸残基取代,编码所述肽的多核苷酸,在体内或体外使用那些肽或多核苷酸的癌症疫苗等。 包含下式的氨基酸序列的肽:XY-Thr-Trp-Asn-Gln-Met-Asn-Leu(SEQ ID NO:4),其中X表示Ser,Ala,Abu,Arg,Lys,Orn,Cit, Leu,Phe或Asn,Y表示Tyr或Met,并且其具有诱导CTL的活性,编码所述肽的多核苷酸,包含那些肽或多核苷酸作为活性成分的癌症疫苗等。
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6.
公开(公告)号:US5234691A
公开(公告)日:1993-08-10
申请号:US603484
申请日:1990-10-26
申请人: Akira Uemura , Fumio Samizo , Tetsuo Noguchi
发明人: Akira Uemura , Fumio Samizo , Tetsuo Noguchi
IPC分类号: A61K9/48 , A61K9/16 , A61K9/20 , A61K9/50 , A61K9/52 , A61K9/58 , A61K9/62 , A61K9/64 , A61K31/425 , A61K47/32 , A61K47/38
CPC分类号: A61K9/2081 , A61K31/425 , A61K9/1635 , A61K9/1652 , A61K9/5047
摘要: A preparation obtained by coating granules containing both a basic medical agent hydrochloride (e.g. allotinolol hydrochloride) and a polyanion the particles of which are present in the form of a discontinuous layer, with a film containing a slightly water-soluble substance, can release said agent at a controlled rate without influenced by the physiological factors of the gastrointestinal tract of a patient when orally administered.
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公开(公告)号:US07879843B2
公开(公告)日:2011-02-01
申请号:US12547574
申请日:2009-08-26
IPC分类号: C07D279/16 , A61K31/5415
CPC分类号: C07C57/58 , C07C45/41 , C07C59/48 , C07C59/68 , C07C69/732 , C07C69/734 , C07C205/58 , C07D279/16 , C07C47/277
摘要: A medicine which contains as an active ingredient a benzothiazin-3-one-compound represented by the formula (1): (wherein n is 3 or 4; R represents ethyl or hydrogen; and R1 represents hologeno, alkoxy, haloalkyl, or haloalkoxy) or a pharmaceutically acceptable salt thereof. It is useful as a therapeutic or preventive agent for arthrosis deformans, chondrodegenerative discases such as chronic articular rheumatism, cancers, gingivitis, etc. Also provided are an intermediate for the compound and a process for producing the compound.
摘要翻译: 作为活性成分含有由式(1)表示的苯并噻嗪-3-酮化合物的药物:(其中n为3或4; R为乙基或氢; R 1为氢原子,烷氧基,卤代烷基或卤代烷氧基) 或其药学上可接受的盐。 作为关节炎变形体的治疗或预防剂,慢性关节风湿病,慢性关节风湿病,牙龈炎等的软骨退行性病变是有用的。还提供了化合物的中间体和化合物的制备方法。
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公开(公告)号:US20100009976A1
公开(公告)日:2010-01-14
申请号:US12547574
申请日:2009-08-26
IPC分类号: A61K31/5415
CPC分类号: C07C57/58 , C07C45/41 , C07C59/48 , C07C59/68 , C07C69/732 , C07C69/734 , C07C205/58 , C07D279/16 , C07C47/277
摘要: A medicine which contains as an active ingredient a benzothiazin-3-one-compound represented by the formula (1): (wherein n is 3 or 4; R represents ethyl or hydrogen; and R1 represents hologeno, alkoxy, haloalkyl, or haloalkoxy) or a pharmaceutically acceptable salt thereof. It is useful as a therapeutic or preventive agent for arthrosis deformans, chondrodegenerative discases such as chronic articular rheumatism, cancers, gingivitis, etc. Also provided are an intermediate for the compound and a process for producing the compound.
摘要翻译: 作为活性成分含有由式(1)表示的苯并噻嗪-3-酮化合物的药物:(其中n为3或4; R为乙基或氢; R 1为氢原子,烷氧基,卤代烷基或卤代烷氧基) 或其药学上可接受的盐。 作为关节炎变形体的治疗或预防剂,慢性关节风湿病,慢性关节风湿病,牙龈炎等的软骨退行性病变是有用的。还提供了化合物的中间体和化合物的制备方法。
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公开(公告)号:US20080058321A1
公开(公告)日:2008-03-06
申请号:US10598516
申请日:2005-02-28
IPC分类号: A61K31/5415 , C07D279/16
CPC分类号: C07C57/58 , C07C45/41 , C07C59/48 , C07C59/68 , C07C69/732 , C07C69/734 , C07C205/58 , C07D279/16 , C07C47/277
摘要: A medicine which contains as an active ingredient a benzothiazin-3-one-compound represented by the formula (1): (wherein n is 3 or 4; R represents ethyl or hydrogen; and R1 represents hologeno, alkoxy, haloalkyl, or haloalkoxy) or a pharmaceutically acceptable salt thereof. It is useful as a therapeutic or preventive agent for arthrosis deformans, chondrodegenerative discases such as chronic articular rheumatism, cancers, gingivitis, etc. Also provided are an intermediate for the compound and a process for producing the compound.
摘要翻译: 作为活性成分含有由式(1)表示的苯并噻嗪-3-酮化合物的药物:(其中n为3或4; R为乙基或氢; R 1为氢原子 ,烷氧基,卤代烷基或卤代烷氧基)或其药学上可接受的盐。 作为关节炎变形体的治疗或预防剂,慢性关节风湿病,慢性关节风湿病,牙龈炎等的软骨退行性病变是有用的。还提供了化合物的中间体和化合物的制备方法。
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公开(公告)号:US06713477B1
公开(公告)日:2004-03-30
申请号:US09959192
申请日:2001-11-09
申请人: Gerard Robert Scarlato , Sara Sabina Hadida Ruah , Tamiki Nishimura , Masashi Nakatsuka , Fumio Samizo , Yumiko Kamikawa , Hitoshi Houtigai
发明人: Gerard Robert Scarlato , Sara Sabina Hadida Ruah , Tamiki Nishimura , Masashi Nakatsuka , Fumio Samizo , Yumiko Kamikawa , Hitoshi Houtigai
IPC分类号: C07D22714
CPC分类号: C07D277/20 , C07D277/14 , C07D277/34 , C07D279/16 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要: A hydroxamic acid derivative represented by formula (1) or a prodrug thereof, or a pharmaceutically acceptable salt thereof, which has a matrix metalo-proteinase inhibitor.
摘要翻译: 由式(1)表示的异羟肟酸衍生物或其前体药物或其药学上可接受的盐,其具有基质金属蛋白酶抑制剂。
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