公开(公告)号：US08911747B2

公开(公告)日：2014-12-16

申请号：US13260835

申请日：2010-03-31

申请人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

发明人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

IPC分类号： A61K39/235 ,  C07K14/005 ,  C12N7/00 ,  A61P31/22 ,  A61K39/245 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16661

摘要： This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same and inducing an anti-HSV immune response in a subject comprising the step of contacting the subject with a composition comprising a mutant HSV strain comprising an inactivating mutation in a Us8 gene, followed by a second contacting with the composition.

摘要翻译： 本发明提供治疗，抑制，抑制，降低发病率，降低发病原因，改善原发性或复发性单纯疱疹病毒（HSV）感染的继发症状或改善症状或延长复发的潜伏期的方法 的HSV感染，以及与其相关的疾病和症状并在受试者中诱导抗HSV免疫应答，包括使受试者与包含在Us8基因中的失活突变的突变HSV病毒组合物接触的步骤，接着是 第二次与组合物接触。

公开(公告)号：US20120114695A1

公开(公告)日：2012-05-10

申请号：US13260835

申请日：2010-03-31

申请人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

发明人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

IPC分类号： A61K39/245 ,  A61P31/22

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16661

摘要： This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same and inducing an anti-HSV immune response in a subject comprising the step of contacting the subject with a composition comprising a mutant HSV strain comprising an inactivating mutation in a Us8 gene, followed by a second contacting with the composition.

摘要翻译： 本发明提供治疗，抑制，抑制，降低发病率，降低发病原因，改善原发性或复发性单纯疱疹病毒（HSV）感染的继发症状或改善症状或延长复发的潜伏期的方法 的HSV感染，以及与其相关的疾病和症状并在受试者中诱导抗HSV免疫应答，包括使受试者与包含在Us8基因中的失活突变的突变HSV病毒组合物接触的步骤，接着是 第二次与组合物接触。