公开(公告)号：US08911747B2

公开(公告)日：2014-12-16

申请号：US13260835

申请日：2010-03-31

申请人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

发明人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

IPC分类号： A61K39/235 ,  C07K14/005 ,  C12N7/00 ,  A61P31/22 ,  A61K39/245 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16661

摘要： This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same and inducing an anti-HSV immune response in a subject comprising the step of contacting the subject with a composition comprising a mutant HSV strain comprising an inactivating mutation in a Us8 gene, followed by a second contacting with the composition.

摘要翻译： 本发明提供治疗，抑制，抑制，降低发病率，降低发病原因，改善原发性或复发性单纯疱疹病毒（HSV）感染的继发症状或改善症状或延长复发的潜伏期的方法 的HSV感染，以及与其相关的疾病和症状并在受试者中诱导抗HSV免疫应答，包括使受试者与包含在Us8基因中的失活突变的突变HSV病毒组合物接触的步骤，接着是 第二次与组合物接触。

公开(公告)号：US20120114695A1

公开(公告)日：2012-05-10

申请号：US13260835

申请日：2010-03-31

申请人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

发明人： Harvey M. Friedman ,  Elizabeth E. Brittle ,  Fushan Wang

IPC分类号： A61K39/245 ,  A61P31/22

CPC分类号： A61K39/245 ,  A61K39/12 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16661

摘要： This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same and inducing an anti-HSV immune response in a subject comprising the step of contacting the subject with a composition comprising a mutant HSV strain comprising an inactivating mutation in a Us8 gene, followed by a second contacting with the composition.

摘要翻译： 本发明提供治疗，抑制，抑制，降低发病率，降低发病原因，改善原发性或复发性单纯疱疹病毒（HSV）感染的继发症状或改善症状或延长复发的潜伏期的方法 的HSV感染，以及与其相关的疾病和症状并在受试者中诱导抗HSV免疫应答，包括使受试者与包含在Us8基因中的失活突变的突变HSV病毒组合物接触的步骤，接着是 第二次与组合物接触。

公开(公告)号：US06287605B1

公开(公告)日：2001-09-11

申请号：US09293758

申请日：1999-04-16

申请人： Daniel Malamud ,  Thandavarayan Nagashunmugam ,  Harvey M. Friedman ,  William Abrams ,  Earl J. Bergey

发明人： Daniel Malamud ,  Thandavarayan Nagashunmugam ,  Harvey M. Friedman ,  William Abrams ,  Earl J. Bergey

IPC分类号： A61K3537

CPC分类号： A61L2/0082 ,  A61K31/70 ,  A61K38/1709 ,  A61K45/06 ,  Y10S435/975

摘要： The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection.

摘要翻译： 本发明包括可用于治疗和预防HIV-1感染的方法的基本上纯化的唾液糖蛋白及其碳水化合物配体的组合物。 本发明还包括用于治疗和预防HIV-1感染的方法，包括将本发明的组合物与人类患者接触。 另外，本发明包括可用于治疗和预防HIV-1感染的抗体和试剂盒。