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公开(公告)号：US09155777B2
公开(公告)日：2015-10-13
申请号：US12740917
申请日：2008-11-05
摘要： The present invention relates to peptide ligands of the melanocortin receptors, in particular the melanocortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as insulin resistance.
摘要翻译： 本发明涉及黑皮质素受体，特别是黑皮质素-4受体的肽配体，因此可用于治疗对该受体的活化反应的病症，例如胰岛素抵抗。
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公开(公告)号：US20100311647A1
公开(公告)日：2010-12-09
申请号：US12740917
申请日：2008-11-05
摘要： The present invention relates to peptide ligands of the melanocortin receptors, in particular the melanocortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as insulin resistance.
摘要翻译： 本发明涉及黑皮质素受体，特别是黑皮质素-4受体的肽配体，因此可用于治疗对该受体的活化反应的病症，例如胰岛素抵抗。
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公开(公告)号：US20160102126A1
公开(公告)日：2016-04-14
申请号：US14922557
申请日：2015-10-26
CPC分类号： C07K14/47 , A61K38/1709 , A61K38/22 , A61K38/2264 , C07K14/4702 , C07K16/18 , G01N33/68
摘要： The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice. Full-length ENHO1 peptide, or peptide derivatives, homologues, analogues, or mimetics thereof, delivered by oral intake, injection, subcutaneous patch, or intranasal routes, could be used as therapeutic or diagnostic agents for hypercholesterolemia, hypertriglyceridemia, insulin resistance, obesity, diabetes, and/or energy imbalance.
摘要翻译： 发现编码推定的76个氨基酸的分泌蛋白（“Enho1”）的mRNA的表达与空腹甘油三酯和胆固醇水平呈负相关。 使用重组腺病毒增加两种小鼠肥胖模型，KK-Ay和Lepob / Lepob小鼠中Enho1 mRNA的表达。 通过腺病毒注射，Enho1的过度表达显着，并且可重复地降低了两种模型中的空腹甘油三酯和胆固醇水平。 此外，制备过表达Enho1蛋白的转基因小鼠品系。 另外，通过在Lepob / Lepob小鼠中的ENHO1腺病毒治疗，参与脂肪生成（脂肪酸合酶）和FAS蛋白水平的关键基因的表达被降低。 通过口服摄入，注射，皮下贴片或鼻内途径递送的全长ENHO1肽或其衍生物，同系物，类似物或模拟物可用作高胆固醇血症，高甘油三酯血症，胰岛素抵抗，肥胖症， 糖尿病和/或能量失衡。
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公开(公告)号：US20100299769A1
公开(公告)日：2010-11-25
申请号：US12848308
申请日：2010-08-02
IPC分类号： A01K67/00 , C07K14/00 , C07K7/08 , C07K14/47 , A61K38/16 , A61K38/10 , A61K38/22 , A61K31/7088 , C07K16/18 , C07H21/04 , A61P3/00 , A61P3/04 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/06
CPC分类号： C07K14/47 , A61K38/1709 , A61K38/22 , A61K38/2264 , C07K14/4702 , C07K16/18 , G01N33/68
摘要： The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice. Full-length ENHO1 peptide, or peptide derivatives, homologues, analogues, or mimetics thereof, delivered by oral intake, injection, subcutaneous patch, or intranasal routes, could be used as therapeutic or diagnostic agents for hypercholesterolemia, hypertriglyceridemia, insulin resistance, obesity, diabetes, and/or energy imbalance.
摘要翻译： 发现编码推定的76个氨基酸的分泌蛋白（“Enho1”）的mRNA的表达与空腹甘油三酯和胆固醇水平呈负相关。 使用重组腺病毒增加两种小鼠肥胖模型，KK-Ay和Lepob / Lepob小鼠中Enho1 mRNA的表达。 通过腺病毒注射，Enho1的过度表达显着，并且可重复地降低了两种模型中的空腹甘油三酯和胆固醇水平。 此外，制备过表达Enho1蛋白的转基因小鼠品系。 另外，通过在Lepob / Lepob小鼠中的ENHO1腺病毒治疗，参与脂肪生成（脂肪酸合酶）和FAS蛋白水平的关键基因的表达被降低。 通过口服摄入，注射，皮下贴片或鼻内途径递送的全长ENHO1肽或其衍生物，同系物，类似物或模拟物可用作高胆固醇血症，高甘油三酯血症，胰岛素抵抗，肥胖症， 糖尿病和/或能量失衡。
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公开(公告)号：US08518892B2
公开(公告)日：2013-08-27
申请号：US12848308
申请日：2010-08-02
CPC分类号： C07K14/47 , A61K38/1709 , A61K38/22 , A61K38/2264 , C07K14/4702 , C07K16/18 , G01N33/68
摘要： The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice. Full-length ENHO1 peptide, or peptide derivatives, homologues, analogues, or mimetics thereof, delivered by oral intake, injection, subcutaneous patch, or intranasal routes, could be used as therapeutic or diagnostic agents for hypercholesterolemia, hypertriglyceridemia, insulin resistance, obesity, diabetes, and/or energy imbalance.
摘要翻译： 发现编码推定的76个氨基酸的分泌蛋白（“Enho1”）的mRNA的表达与空腹甘油三酯和胆固醇水平呈负相关。 使用重组腺病毒增加两种小鼠肥胖模型，KK-Ay和Lepob / Lepob小鼠中Enho1 mRNA的表达。 通过腺病毒注射，Enho1的过度表达显着，并且可重复地降低了两种模型中的空腹甘油三酯和胆固醇水平。 此外，制备过表达Enho1蛋白的转基因小鼠品系。 另外，通过在Lepob / Lepob小鼠中的ENHO1腺病毒治疗，参与脂肪生成（脂肪酸合酶）和FAS蛋白水平的关键基因的表达被降低。 通过口服摄入，注射，皮下贴片或鼻内途径递送的全长ENHO1肽或其衍生物，同系物，类似物或模拟物可用作高胆固醇血症，高甘油三酯血症，胰岛素抵抗，肥胖症， 糖尿病和/或能量失衡。
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公开(公告)号：US20100306866A1
公开(公告)日：2010-12-02
申请号：US12460020
申请日：2009-07-10
申请人： Andrew A. Butler
发明人： Andrew A. Butler
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0362
摘要： Mice lacking expression of the Enho gene provide useful tools in the study of the Enho gene and to investigate possible treatments for glucose, lipid and energy metabolism.
摘要翻译： 缺乏Enho基因表达的小鼠在Enho基因的研究中提供了有用的工具，并调查了对葡萄糖，脂质和能量代谢的可能处理。
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公开(公告)号：US20090253619A1
公开(公告)日：2009-10-08
申请号：US12012627
申请日：2008-02-05
IPC分类号： A61K38/16 , C07K14/435 , C07K14/00 , C07K7/08 , A61K38/10 , A61P3/04 , A61K38/22 , C12N15/63 , C12N1/20 , C12N1/16 , C12N5/06 , C12N5/04 , C12P21/00 , A61K31/7088 , C07K16/18 , A01K67/00 , A01K67/027
CPC分类号： C07K14/47 , A61K38/1709 , A61K38/22 , A61K38/2264 , C07K14/4702 , C07K16/18 , G01N33/68
摘要： The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of Enho1 mRNA in two mouse models of obesity, KK-Ay and Lepob/Lepob mice. Over-expression of Enho1 by adenovirus injection significantly, and reproducibly, reduced fasting triglyceride and cholesterol levels in both models. In addition, transgenic mice strains were made that over express Enho1 protein. Additionally, the expression of a key gene involved in lipogenesis (fatty acid synthase) and FAS protein levels were reduced by ENHO1 adenoviral treatment in Lepob/Lepob mice. Full-length ENHO1 peptide, or peptide derivatives, homologues, analogues, or mimetics thereof, delivered by oral intake, injection, subcutaneous patch, or intranasal routes, could be used as therapeutic or diagnostic agents for hypercholesterolemia, hypertriglyceridemia, insulin resistance, obesity, diabetes, and/or energy imbalance.
摘要翻译： 发现编码推定的76个氨基酸的分泌蛋白（“Enho1”）的mRNA的表达与空腹甘油三酯和胆固醇水平呈负相关。 使用重组腺病毒增加两种小鼠肥胖模型，KK-Ay和Lepob / Lepob小鼠中Enho1 mRNA的表达。 通过腺病毒注射，Enho1的过度表达显着，并且可重复地降低了两种模型中的空腹甘油三酯和胆固醇水平。 此外，制备过表达Enho1蛋白的转基因小鼠品系。 另外，通过在Lepob / Lepob小鼠中的ENHO1腺病毒治疗，参与脂肪生成（脂肪酸合酶）和FAS蛋白水平的关键基因的表达被降低。 通过口服摄入，注射，皮下贴片或鼻内途径递送的全长ENHO1肽或其衍生物，同系物，类似物或模拟物可用作高胆固醇血症，高甘油三酯血症，胰岛素抵抗，肥胖症， 糖尿病和/或能量失衡。
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