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公开(公告)号：US20060100207A1
公开(公告)日：2006-05-11
申请号：US10525608
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07F7/1804
摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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公开(公告)号：US07230017B2
公开(公告)日：2007-06-12
申请号：US10525608
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/4412 , A61K31/444 , A61K31/5377 , A61K31/4439 , A61K31/4436 , A61K31/496 , A61K31/4545 , C07D401/02 , C07D413/02 , C07D211/86 , C07D213/22 , C07D417/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07F7/1804
摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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3.发明授权Dihydropyridine derivatives for use as human neutrophil elastase inhibitors 失效用作人嗜中性粒细胞弹性蛋白酶抑制剂的二氢吡啶衍生物公开(公告)号：US07691854B2
公开(公告)日：2010-04-06
申请号：US10525867
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/44 , C07D213/72 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07D413/04 , C07D417/04
摘要： The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及式（I）的新型二氢吡啶衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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4.发明授权Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes 有权嘧啶酮衍生物作为抗急性和慢性炎性，缺血和重塑过程的治疗剂公开(公告)号：US07687510B2
公开(公告)日：2010-03-30
申请号：US10527391
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： C07D239/22 , C07D401/04 , A61K31/5377
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。
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5.发明申请I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE 失效I-PHENY 1-3,4-二羟基嘧啶-2（1H） - 酮衍生物及其用途公开(公告)号：US20100022537A1
公开(公告)日：2010-01-28
申请号：US12509936
申请日：2009-07-27
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , C07D239/02 , A61K31/505 , C07D413/02 , A61P29/00 , A61P9/00
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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6.发明授权1-phenyl1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use 失效1-苯基-3,4-二氢嘧啶-2（1H） - 酮衍生物及其用途公开(公告)号：US07566723B2
公开(公告)日：2009-07-28
申请号：US10527386
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention relates to novel 1-Phenyl-3,4-dihydropyrimidin-2(1H)-one derivatives having the formula processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及具有其制备方法的新型1-苯基-3,4-二氢嘧啶-2（1H） - 酮衍生物及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征， 急性心肌梗死和心力衰竭发展。
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7.发明授权I-pheny 1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use 失效1-苯基-1,3,4-二氢嘧啶-2（1H） - 酮衍生物及其用途公开(公告)号：US08173665B2
公开(公告)日：2012-05-08
申请号：US12509936
申请日：2009-07-27
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention relates to 4-cyanophenyl, 2-sulfanyl, 1-phenyl pyrimidine derivatives, processes for their preparation, and pharmaceutical compositions of the same. Compounds and compositions of the invention are useful in the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.
摘要翻译： 本发明涉及4-氰基苯基，2-硫烷基，1-苯基嘧啶衍生物，其制备方法及其药物组合物。 本发明的化合物和组合物可用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗死和心力衰竭发展。
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8.发明申请Dihydropyridine derivatives for use as human neutrophil elastase inhibitors 失效用作人嗜中性粒细胞弹性蛋白酶抑制剂的二氢吡啶衍生物公开(公告)号：US20070167406A1
公开(公告)日：2007-07-19
申请号：US10525867
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schiemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schiemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/695 , C07F7/02 , A61K31/5377 , A61K31/496 , A61K31/4545 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07D413/04 , C07D417/04
摘要： The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及式（I）的新型二氢吡啶衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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公开(公告)号：US20050165014A1
公开(公告)日：2005-07-28
申请号：US10498967
申请日：2002-12-09
申请人： Heike Gielen -Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Kevin Nash , Mary Fitzgerald
发明人： Heike Gielen -Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Kevin Nash , Mary Fitzgerald
IPC分类号： A61K31/4422 , A61K31/444 , A61P11/00 , A61P29/00 , C07D211/90 , C07D401/04 , A61K31/5377 , A61K31/496 , C07D413/02 , C07D43/14
CPC分类号： C07D401/04 , C07D211/90
摘要： The invention relates to novel 1,4-dihydro-1,4-diphenylpyridine derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新的1,4-二氢-1,4-二苯基吡啶衍生物，其制备方法及其在药物中的应用，特别是用于治疗慢性阻塞性肺疾病。
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公开(公告)号：US07199136B2
公开(公告)日：2007-04-03
申请号：US10498967
申请日：2002-12-09
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Kevin Nash , Mary Fitzgerald
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Kevin Nash , Mary Fitzgerald
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07D401/04 , C07D211/90
摘要： The invention relates to novel 1,4-dihydro-1,4-diphenylpyridine derivatives of formula (I) wherein the variable groups are as defined in the text and claims. Processes for their preparation, pharmaceutical compositions containing them, and methods of treatment of inflammatory processes, expecially chronic obstructive pulmonary diseases, using them are also disclosed and claimed.
摘要翻译： 本发明涉及式（I）的新型1,4-二氢-1,4-二苯基吡啶衍生物，
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