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公开(公告)号：US07208140B2
公开(公告)日：2007-04-24
申请号：US10780887
申请日：2004-02-19
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Jose Luis Martin , Juan R. Harto , Bjoern Riefke
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Jose Luis Martin , Juan R. Harto , Bjoern Riefke
IPC分类号： A61B5/055 , C07F5/00 , C07D225/00 , C07D243/14
CPC分类号： A61K49/10 , A61K49/0002 , A61K49/0438 , A61K49/085 , A61K49/106 , C07D257/02
摘要： The metal complexes of general formula I in which Hal stands for bromine or iodine and A1 and A2 have different meanings, are suitable as contrast media.
摘要翻译： 其中Hal代表溴或碘的通式I的金属络合物和具有不同含义的适合作为造影剂。
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公开(公告)号：US07385054B2
公开(公告)日：2008-06-10
申请号：US11272008
申请日：2005-11-14
IPC分类号： C07D295/02 , C07D295/023 , C07D249/02
CPC分类号： A61K49/0002 , A61K49/0438 , A61K49/085 , A61K49/10 , C07D257/02
摘要： The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media.
摘要翻译： 其中Hal代表溴或碘的通式I的金属络合物和具有不同含义的A 1和A 2都适用作造影剂。
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公开(公告)号：US20060154989A1
公开(公告)日：2006-07-13
申请号：US11272008
申请日：2005-11-14
IPC分类号： A61K31/165
CPC分类号： A61K49/0002 , A61K49/0438 , A61K49/085 , A61K49/10 , C07D257/02
摘要： The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media.
摘要翻译： 其中Hal代表溴或碘的通式I的金属络合物和具有不同含义的A 1和A 2都适用作造影剂。
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4.发明申请Trimeric, macrocyclically substituted aminoisophthalic acid-halo-benzene derivatives 审中-公开三环，大环环取代的氨基间苯二甲酸 - 卤代苯衍生物公开(公告)号：US20060120965A1
公开(公告)日：2006-06-08
申请号：US11274895
申请日：2005-11-16
CPC分类号： A61K49/0438 , A61K49/085 , A61K49/106 , C07D257/02
摘要： The metal complexes of general formula I in which Hal stands for bromine or iodine, and A1 and A2 have different meanings, are suitable as contrast media.
摘要翻译： 其中Hal代表溴或碘的通式I的金属络合物和具有不同含义的A 1和A 2都适用作造影剂。
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5.发明申请METAL CHELATES HAVING A PERFLUORINATED PEG RADICAL, PROCESSES FOR THEIR PREPARATION, AND THEIR USE 失效具有全氟代PEG辐射的金属螯合物，其制备方法及其使用公开(公告)号：US20080159954A1
公开(公告)日：2008-07-03
申请号：US11873986
申请日：2007-10-17
IPC分类号： A61K49/00 , C07C229/00 , C07H15/00
CPC分类号： C07D257/02 , A61K49/0433 , A61K49/085 , A61K49/126 , A61K51/0474 , C07D213/81
摘要： The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
摘要翻译： 本发明涉及专利权利要求所述的受试者，即具有全氟化PEG基团的金属螯合物，其制备方法及其用途，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，以及 在MRT淋巴瘤中。
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6.发明申请Perfluoroalkyl-containing complexes, process for their production as well as their use 失效含全氟烷基的络合物，其制备方法及其用途公开(公告)号：US20070189969A1
公开(公告)日：2007-08-16
申请号：US11487604
申请日：2006-07-17
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A61B5/055 , A61K49/04 , C07D257/02
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译： 本发明涉及权利要求中特征的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如 如在MRT淋巴瘤和血液池成像中。
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7.发明授权Metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use 失效具有全氟化PEG基团的金属螯合物，其制备方法及其用途公开(公告)号：US08263040B2
公开(公告)日：2012-09-11
申请号：US11873986
申请日：2007-10-17
IPC分类号： A61K51/00
CPC分类号： C07D257/02 , A61K49/0433 , A61K49/085 , A61K49/126 , A61K51/0474 , C07D213/81
摘要： The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
摘要翻译： 本发明涉及专利权利要求所述的受试者，即具有全氟化PEG基团的金属螯合物，其制备方法及其用途，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，以及 在MRT淋巴瘤中。
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8.发明授权Perfluoroalkyl-containing complexes, process for their production as well as their use 失效含全氟烷基的络合物，其制备方法及其用途公开(公告)号：US07618957B2
公开(公告)日：2009-11-17
申请号：US11487604
申请日：2006-07-17
申请人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
发明人： Heiko Schirmer , Hanns-Joachim Weinmann , Johannes Platzek , Ludwig Zorn , Bernd Misselwitz , Joerg Meding , Heribert Schmitt-Willich , Thomas Brumby
IPC分类号： A01N43/00 , A61K31/33 , C07D245/00
CPC分类号： C07D257/02 , A61K49/0002 , A61K49/04 , A61K49/103 , A61K49/106 , A61K51/0478 , A61K51/0482
摘要： The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
摘要翻译： 本发明涉及权利要求所述的受试者，即具有通式I的含氮基团的全氟烷基金属络合物，其制备方法及其在NMR和X射线诊断，放射诊断和放射治疗中的用途，如 如在MRT淋巴瘤和血液池成像中。
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9.发明申请Conjugates of macrocyclic metal complexes with biomolecules and their use for the production of agents for NMR diagnosis and radiodiagnosis as well as radiotherapy 审中-公开大环金属配合物与生物分子的共轭物及其用于生产核磁共振诊断和放射诊断以及放射治疗剂的用途公开(公告)号：US20070014725A1
公开(公告)日：2007-01-18
申请号：US11390414
申请日：2006-03-28
申请人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
CPC分类号： A61K49/14 , A61K49/0002 , A61K49/085 , A61K49/143
摘要： The invention relates to conjugates that consist of macrocyclic metal complexes with biomolecules and their production. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as as agents for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
摘要翻译： 本发明涉及由大环金属配合物与生物分子组成的共轭物及其生产。 缀合物适用于核磁共振诊断和放射诊断中的造影剂以及放射治疗剂。 通过大环化合物的特殊结合实现高的放松性，并且可以进行微调的松弛度。
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10.发明申请公开(公告)号：US20070009442A1
公开(公告)日：2007-01-11
申请号：US11390472
申请日：2006-03-28
申请人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Gunther Michl , Thomas Frenzel , Detlev Sulzle , Hans Bauer , Bernd Raduchel , Hanns-Joachim Weinmann , Heiko Schirmer
IPC分类号： A61K49/10 , C07K14/47 , C07H21/04 , C07D257/02 , C07D487/22
CPC分类号： A61K49/10 , A61K47/54 , A61K47/547 , A61K49/0002 , A61K49/085 , A61K49/14 , A61K49/143 , C07D257/02
摘要： The invention relates to macrocyclic metal complexes and their production and use for the production of conjugates with biomolecules. The conjugates are suitable as contrast media in NMR diagnosis and radiodiagnosis as well as for radiotherapy. High relaxivity is achieved by a special liganding of macrocyclic compounds, and a fine-tuning of the relaxivity is made possible.
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