公开(公告)号：US06646108B1

公开(公告)日：2003-11-11

申请号：US09101430

申请日：1998-07-09

申请人： Heinz Leibl ,  Regine Tomasits ,  Josef Mannhalter ,  Hermann Wolf ,  Martha Eibl

发明人： Heinz Leibl ,  Regine Tomasits ,  Josef Mannhalter ,  Hermann Wolf ,  Martha Eibl

IPC分类号： A61K39395

CPC分类号： C07K16/065 ,  Y10S424/804 ,  Y10S530/861

摘要： A method for the separation of IgG and IgA from an immunoglobulin-containing starting material is described, whereby the method is characterized in that (i) IgG and optionally IgA are adsorbed to a solid inorganic carrier material, (ii) IgA is isolated from the eluate, optionally after selective desorption, whereas IgG remains on the carrier material, and optionally (iii) IgG is isolated from the adsorbate. Furthermore, an IgA preparation is disclosed which demonstrates a low tendency to form aggregates.

摘要翻译： 描述了从含有免疫球蛋白的原料中分离IgG和IgA的方法，其中该方法的特征在于：（i）IgG和任选的IgA被吸附到固体无机载体材料上，（ii）IgA从 洗脱液，任选地在选择性解吸后，而IgG保留在载体材料上，并且任选地（iii）从被吸附物中分离IgG。 此外，公开了表现出形成聚集体的低倾向的IgA制剂。

公开(公告)号：US5808000A

公开(公告)日：1998-09-15

申请号：US500161

申请日：1995-07-10

申请人： Josef W. Mannhalter ,  Heinz Leibl ,  Martha Eibl ,  Regine Tomasits ,  Hermann Wolf

发明人： Josef W. Mannhalter ,  Heinz Leibl ,  Martha Eibl ,  Regine Tomasits ,  Hermann Wolf

IPC分类号： A61K39/395 ,  C07K1/16 ,  C07K1/20 ,  C07K1/22 ,  C07K16/00 ,  C07K16/06

CPC分类号： C07K16/065

摘要： A virus-safe monomeric human IgA is described which is essentially free of IgG. The IgA according to the invention is obtainable according to a process in which (a) an IgA-containing fraction is subjected to a purification such that a monomeric IgA which is essentially free of IgG is obtained and (b) the obtained product is subjected to a process for the inactivation of viruses.

摘要翻译： 描述了基本上不含IgG的病毒安全的单体人IgA。 根据本发明的IgA可以根据以下方法获得：（a）使含IgA的级分进行纯化，使得获得基本上不含IgG的单体IgA，和（b）将所得产物进行 一种灭活病毒的过程。