-
1.发明授权Genetically modified cyclic-nucleotide controlled ion channels and the use thereof 失效遗传修饰的环核苷酸控制离子通道及其用途公开(公告)号：US07417117B2
公开(公告)日：2008-08-26
申请号：US10486316
申请日：2002-08-06
CPC分类号： C07K14/705
摘要： The present invention relates to genetically modified cyclic nucleotide-gated ion channels whose subunits have been altered so as to have higher sensitivity to cAMP and/or higher selectivity for cAMP compared to cGMP in comparison with the wild type according to SEQ ID NO 1 and 2.
摘要翻译： 本发明涉及基因修饰的环核苷酸门控离子通道，其与根据SEQ ID NO：1和2的野生型相比，其亚基已被改变以具有比cAMP高的cAMP敏感性和/或cCMP的较高选择性 。
-
公开(公告)号：US07951914B2
公开(公告)日：2011-05-31
申请号：US12182395
申请日：2008-07-30
CPC分类号： C07K14/705
摘要： A genetically modified cyclic-nucleotide controlled ion channels where the subunits thereof are altered in such a manner that they have a higher sensitivity for cAMP in relation to cGMP in comparison with the Wildtype according to Seq ID No. 1 and 2.
摘要翻译： 基因修饰的环核苷酸控制的离子通道，其亚基以相对于cGMP相对于cGMP具有更高灵敏度的方式改变，与根据Seq ID No.1和2的野生型相比。
-
3.发明申请Genetically modified cyclic-nucleotide controlled ion channels and the use thereof 失效遗传修饰的环核苷酸控制离子通道及其用途公开(公告)号：US20060073468A1
公开(公告)日：2006-04-06
申请号：US10486316
申请日：2002-08-06
IPC分类号： C12Q1/00 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705
摘要： The present invention relates to genetically modified cyclic nucleotide-gated ion channels whose subunits have been altered so as to have higher sensitivity to cAMP and/or higher selectivity for cAMP compared to cGMP in comparison with the wild type according to SEQ ID NO 1 and 2.
摘要翻译： 本发明涉及基因修饰的环核苷酸门控离子通道，其与根据SEQ ID NO：1和2的野生型相比，其亚基已被改变以具有比cAMP高的cAMP敏感性和/或cCMP的较高选择性 。
-
公开(公告)号：US07112667B1
公开(公告)日：2006-09-26
申请号：US09640582
申请日：2000-08-17
申请人： Arnd Baumann , Wolfgang Bönigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
发明人： Arnd Baumann , Wolfgang Bönigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
IPC分类号： C07H21/04 , C12N15/63 , C12N1/15 , C12N15/12 , G01N33/566
CPC分类号： C07K14/43581 , A61K38/00 , A61K48/00 , C07K14/43504 , C07K14/705
摘要： The present invention relates to a nucleic acid, preferably a DNA, comprising at least a part of the sequence of an Ih ion channel. Said sequence may e.g. be derived from a human DNA, a rat DNA, a bovine DNA, a Drosophila melanogaster DNA or a sea urchin DNA. Furthermore, the present invention relates to an mRNA molecule which contains the corresponding sequences. The invention further relates to a polypeptide or protein encoded by the nucleic acid.Furthermore, the invention relates to the use of the inventive nucleic acid and proteins for a screening and/or diagnosing method and to the kits required therefor.Lastly, the invention relates to the use of one or more nucleic acids and proteins for the treatment and/or prophylaxis of cardiovascular disorders and disturbances of consciousness.
摘要翻译： 本发明涉及一种核酸，优选DNA，其包含至少一部分I H H离子通道的序列。 所述序列可以例如。 衍生自人类DNA，大鼠DNA，牛DNA，果蝇黑腹果蝇DNA或海胆DNA。 此外，本发明涉及含有相应序列的mRNA分子。 本发明还涉及由该核酸编码的多肽或蛋白质。 此外，本发明涉及本发明的核酸和蛋白质用于筛选和/或诊断方法及其所需的试剂盒的用途。 最后，本发明涉及一种或多种核酸和蛋白质用于治疗和/或预防心血管疾病和意识障碍的用途。
-
公开(公告)号：US20080248486A1
公开(公告)日：2008-10-09
申请号：US11664541
申请日：2005-09-30
申请人： Natalie Watzke , Maarten Ruitenberg , Wolfgang Dorner , Renate Gauss , Bela Kelety , Joanna Tobien
发明人： Natalie Watzke , Maarten Ruitenberg , Wolfgang Dorner , Renate Gauss , Bela Kelety , Joanna Tobien
CPC分类号： C12Q1/001
摘要： The present invention relates to a type PepT1 protein assay and in particular a process for identifying a substrate and/or a modulator of the PepT1 protein.
摘要翻译： 本发明涉及一种PepT1型蛋白质测定法，特别涉及用于鉴定PepT1蛋白质的底物和/或调节剂的方法。
-
公开(公告)号：US07547763B2
公开(公告)日：2009-06-16
申请号：US11497168
申请日：2006-08-01
申请人： Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
发明人： Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
CPC分类号： C07K14/43581 , A61K38/00 , A61K48/00 , C07K14/43504 , C07K14/705
摘要： The present invention relates to an isolated or purified human nucleic acid, preferably a DNA, comprising a nucleotide sequence encoding an Ih ion channel. The invention further relates to a vector comprising the isolated or purified nucleic acid, a host cell comprising the vector, and a composition comprising the isolated or purified nucleic acid and a carrier therefore. The invention also provides a polypeptide or protein encoded by the nucleic acid, and a method of treating a mammal for a cardiovascular disorder.
摘要翻译： 本发明涉及分离或纯化的人核酸，优选DNA，其包含编码Ih离子通道的核苷酸序列。 本发明还涉及包含分离或纯化的核酸的载体，包含载体的宿主细胞，以及包含分离或纯化的核酸和载体的组合物。 本发明还提供了由核酸编码的多肽或蛋白质，以及治疗哺乳动物心血管疾病的方法。
-
公开(公告)号：US20060269959A1
公开(公告)日：2006-11-30
申请号：US11497168
申请日：2006-08-01
申请人： Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
发明人： Arnd Baumann , Wolfgang Bonigk , Renate Gauss , Alexander Scholten , Reinhard Seifert , Benjamin Kaupp
CPC分类号： C07K14/43581 , A61K38/00 , A61K48/00 , C07K14/43504 , C07K14/705
摘要： The present invention relates to an isolated or purified human nucleic acid, preferably a DNA, comprising a nucleotide sequence encoding an Ih ion channel. The invention further relates to a vector comprising the isolated or purified nucleic acid, a host cell comprising the vector, and a composition comprising the isolated or purified nucleic acid and a carrier therefore. The invention also provides a polypeptide or protein encoded by the nucleic acid, and a method of treating a mammal for a cardiovascular disorder.
摘要翻译： 本发明涉及分离或纯化的人核酸，优选DNA，其包含编码I H h离子通道的核苷酸序列。 本发明还涉及包含分离或纯化的核酸的载体，包含载体的宿主细胞，以及包含分离或纯化的核酸和载体的组合物。 本发明还提供了由核酸编码的多肽或蛋白质，以及治疗哺乳动物心血管疾病的方法。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.024 秒)