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公开(公告)号：US06287809B1
公开(公告)日：2001-09-11
申请号：US09224247
申请日：1998-12-30
IPC分类号： C12P2106
CPC分类号： C07K14/005 , A61K38/00 , C07K16/1036 , C12N2740/10022 , C12N2740/10043 , C12N2740/14022 , C12N2740/14043 , C12N2740/16322 , G03C7/3013 , G03C7/36
摘要： Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example protect cells against the deleterious effects of viral, e.g. HIV-1, infection.
摘要翻译： 衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II，在某些情况下，均为Rev和Rex功能，因此在多种病毒物种中活跃。 这样的显性病毒突变体可用作抗病毒剂，例如保护细胞免受病毒的有害影响，例如， HIV-1，感染。
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2.发明授权Mutant rex genes encoding transdominant repressors of HIV/HTLV replication 失效编码HIV / HTLV复制的横显性阻遏物的突变型rex基因公开(公告)号：US06339150B1
公开(公告)日：2002-01-15
申请号：US09137784
申请日：1998-08-21
IPC分类号： C07H2104
CPC分类号： C07K14/005 , A61K38/00 , C07K16/1036 , C12N2740/10022 , C12N2740/10043 , C12N2740/14022 , C12N2740/14043 , C12N2740/16322 , G03C7/3013 , G03C7/36
摘要： Transdominant repressors of viral gene phenotypic expression derived from the rev gene product of HIV-1 or the rex gene product of HTLV-1 and corresponding mutated genes, having the capability of repressing the Rev function in HIV-1 and/or the Rex function in HTLV-I and HTLV-II and, in some cases, both the Rev and the Rex function and are, therefore, active in more than one viral species. Such transdominant viral mutants are useful as anti-viral agents to, for example protect cells against the deleterious effects of viral, e.g. HIV-1, infection.
摘要翻译： 衍生自HIV-1的rev基因产物或HTLV-1的rex基因产物和相应的突变基因的具有抑制HIV-1中Rev功能和/或Rex功能的能力的病毒基因表型表达的显性阻遏物 HTLV-I和HTLV-II，在某些情况下，均为Rev和Rex功能，因此在多种病毒物种中活跃。 这样的显性病毒突变体可用作抗病毒剂，例如保护细胞免受病毒的有害影响，例如， HIV-1，感染。
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公开(公告)号：US20090156476A1
公开(公告)日：2009-06-18
申请号：US11886007
申请日：2006-03-09
摘要： Disclosed is a polypeptide comprising at least two microproteins, which preferably comprise an amino acid sequence having a specific binding activity to a target protein. Furthermore, disclosed are polynucleotides encoding such a polypeptide as well as pharmaceutical compositions and kits comprising said polypeptide or polynucleotide. Also disclosed herein are methods of treatments and second medical uses applying the disclosed polypeptide or polynucleotide. Additionally, the disclosure of the present application relates to a method for forming a covalent bond in a microprotein which can be used for producing the disclosed polypeptides.
摘要翻译： 公开了包含至少两种微蛋白的多肽，其优选包含对靶蛋白具有特异性结合活性的氨基酸序列。 此外，公开了编码这种多肽的多核苷酸以及包含所述多肽或多核苷酸的药物组合物和试剂盒。 本文还公开了应用所公开的多肽或多核苷酸的治疗方法和第二医疗用途。 此外，本申请的公开内容涉及在微蛋白中形成共价键的方法，其可用于制备所公开的多肽。
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公开(公告)号：US06776986B1
公开(公告)日：2004-08-17
申请号：US09194300
申请日：1998-11-23
申请人： Ernst Boehnlein , Sonia Escaich , Heini Ilves , Gabor Veres
发明人： Ernst Boehnlein , Sonia Escaich , Heini Ilves , Gabor Veres
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K38/00 , A61K48/005 , C12N2310/111 , C12N2740/13043 , C12N2740/16322
摘要： Novel antisense sequences to the unspliced or single spliced portions of mRNA transcript from HIV-1 provirus, optionally co-expressed with an inhibitory transdominant mutant HIV-1 protein, are found to be useful in the treatment of HIV-1 infection.
摘要翻译： 发现HIV-1前病毒的mRNA转录物的未剪接或单个剪接部分的任何与抑制性跨越型突变HIV-1蛋白共表达的新反义序列可用于治疗HIV-1感染。
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公开(公告)号：US08258258B2
公开(公告)日：2012-09-04
申请号：US11886007
申请日：2006-03-09
IPC分类号： A61K38/16
摘要： Disclosed is a polypeptide comprising at least two microproteins, which preferably comprise an amino acid sequence having a specific binding activity to a target protein. Furthermore, disclosed are polynucleotides encoding such a polypeptide as well as pharmaceutical compositions and kits comprising said polypeptide or polynucleotide. Also disclosed herein are methods of treatments and second medical uses applying the disclosed polypeptide or polynucleotide. Additionally, the disclosure of the present application relates to a method for forming a covalent bond in a microprotein which can be used for producing the disclosed polypeptides.
摘要翻译： 公开了包含至少两种微蛋白的多肽，其优选包含对靶蛋白具有特异性结合活性的氨基酸序列。 此外，公开了编码这种多肽的多核苷酸以及包含所述多肽或多核苷酸的药物组合物和试剂盒。 本文还公开了应用所公开的多肽或多核苷酸的治疗方法和第二医疗用途。 此外，本申请的公开内容涉及在微蛋白中形成共价键的方法，其可用于制备所公开的多肽。
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