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公开(公告)号：US20080124741A1
公开(公告)日：2008-05-29
申请号：US11664383
申请日：2005-10-11
申请人： Heng Dai , Magda F. Morton , Jayashree Pyati , Nigel P. Shankley
发明人： Heng Dai , Magda F. Morton , Jayashree Pyati , Nigel P. Shankley
IPC分类号： G01N33/567 , C07K14/00 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： G01N33/566 , C07K14/705 , G01N2333/595 , G01N2500/04 , G01N2500/10
摘要： Canine CCK1 receptor materials are described, such as polypeptides having amino acid sequences corresponding to SEQ ID Nos.: 14, 15, and 16 or functional variants thereof and polynucleotides expressing them having nucleic acid sequences corresponding to SEQ ID Nos.: 11, 12, and 13 or complements thereof. Such materials are useful as reagents in drug screening assays to identify compounds having CCK1R-modulating activity.
摘要翻译： 描述了犬CCK1受体材料，例如具有对应于SEQ ID NO：14,15和16的氨基酸序列的多肽或其功能变体，以及表达它们的多核苷酸具有对应于SEQ ID NO：11,12， 和13或其互补物。 这样的材料可用作药物筛选测定中的试剂，以鉴定具有CCK1R调节活性的化合物。
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2.发明授权Methods of use of DNA encoding a human histamine receptor of the H3 subtype 有权使用编码H3亚型的人组胺受体的DNA的方法公开(公告)号：US07179604B2
公开(公告)日：2007-02-20
申请号：US10727021
申请日：2003-12-02
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US06548270B1
公开(公告)日：2003-04-15
申请号：US09518959
申请日：2000-03-03
IPC分类号： C12N1512
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding human acid sensing ion channel BnaC4 has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 已经克隆并表征编码人感应离子通道BnaC4的DNA。 重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US06413743B1
公开(公告)日：2002-07-02
申请号：US09642855
申请日：2000-08-21
IPC分类号： C12N510
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US07049401B1
公开(公告)日：2006-05-23
申请号：US09642853
申请日：2000-08-21
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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6.发明授权公开(公告)号：US06855560B1
公开(公告)日：2005-02-15
申请号：US09642852
申请日：2000-08-21
IPC分类号： C07K14/72 , C12N15/12 , G01N33/53 , G01N33/567
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US06437100B1
公开(公告)日：2002-08-20
申请号：US09642514
申请日：2000-08-21
IPC分类号： C07K1628
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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公开(公告)号：US06358706B1
公开(公告)日：2002-03-19
申请号：US09426998
申请日：1999-10-26
IPC分类号： C12N510
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/026
摘要： A DNA molecule encoding a novel isoform of the human T-type low voltage activated calcium channel (alpha1G-c) has been cloned and characterized. The biological and structural properties of this protein is disclosed, as is the amino acid and nucleotide sequence.
摘要翻译： 已经克隆并表征了编码人T型低电压活化钙通道（α1G-c）的新型同工型的DNA分子。 公开了该蛋白质的生物学和结构性质，以及氨基酸和核苷酸序列。
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公开(公告)号：US6136559A
公开(公告)日：2000-10-24
申请号：US167354
申请日：1998-10-07
CPC分类号： C07K14/723 , C12N2799/026
摘要： DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译： 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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