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公开(公告)号：US06613877B2
公开(公告)日：2003-09-02
申请号：US09361736
申请日：1999-07-28
IPC分类号： C07K1400
CPC分类号： C07H21/04 , C07K14/575
摘要： A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the regulation of electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis and Paget's Disease. Antagonists against such polypeptides and their use in the regulation of electrolyte imbalances which can lead to hypocalcemia and osteoporosis are also disclosed.
摘要翻译： 公开了一种编码这种多肽的人类猕猴素α多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来调节可导致肾，骨和心脏病以及骨质疏松症和佩吉特氏病的电解质不平衡的方法。 还公开了抗这些多肽的拮抗剂及其在调节可导致低钙血症和骨质疏松症的电解质不平衡中的用途。
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公开(公告)号：US5986069A
公开(公告)日：1999-11-16
申请号：US442497
申请日：1995-05-16
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K39/395 , A61K48/00 , A61P7/00 , A61P7/06 , A61P25/00 , A61P35/02 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/475 , C07K16/18 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/68
CPC分类号： C07K14/475 , A61K38/00
摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。 还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。 还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。
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