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    Human haemopoietic maturation factor
    2.
    发明授权
    Human haemopoietic maturation factor 失效
    人类造血成熟因子

    公开(公告)号：US06790826B2

    公开(公告)日：2004-09-14

    申请号：US10004832

    申请日：2001-12-07

    申请人： Ewen F. Kirkness ,  Mark D. Adams ,  Henrik Olsen ,  Craig A. Rosen

    发明人： Ewen F. Kirkness ,  Mark D. Adams ,  Henrik Olsen ,  Craig A. Rosen

    IPC分类号： A61K3816

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： Disclosed are human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and for using such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations are also disclosed. Diagnostic assays are also disclosed to detect both the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.

    摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法，并且使用这些多肽来治疗白血病，自身免疫疾病和与血液相关的疾病。 还公开了抗这些多肽的拮抗剂及其作为治疗剂用于预防T细胞群扩增的用途。 还公开了诊断测定以检测造血成熟因子核酸序列中突变的存在和蛋白质的改变的水平。

    Antibodies that bind human haemopoietic maturation factor
    3.
    发明授权
    Antibodies that bind human haemopoietic maturation factor 失效
    结合人类造血成熟因子的抗体

    公开(公告)号：US06346246B1

    公开(公告)日：2002-02-12

    申请号：US09333033

    申请日：1999-06-15

    申请人： Ewen F. Kirkness ,  Mark D. Adams ,  Henrik S. Olsen ,  Craig A. Rosen

    发明人： Ewen F. Kirkness ,  Mark D. Adams ,  Henrik S. Olsen ,  Craig A. Rosen

    IPC分类号： A61K39395

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： Disclosed is human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and the use of such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations is also disclosed. Diagnostic assays are also disclosed which detect the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.

    摘要翻译： 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA（RNA）。 还提供了通过重组技术产生此类多肽的方法以及使用这些多肽来治疗白血病，自身免疫疾病和血液相关病症。 还公开了抗这些多肽的拮抗剂及其作为预防T细胞群扩增的治疗剂的用途。 还公开了诊断测定法，其检测造血成熟因子核酸序列中突变的存在和蛋白质的改变水平。

    Human geranylgeranyl pyrophosphate synthetase
    9.
    发明授权
    Human geranylgeranyl pyrophosphate synthetase 失效
    人类香叶基香叶基焦磷酸合成酶

    公开(公告)号：US5928924A

    公开(公告)日：1999-07-27

    申请号：US38596

    申请日：1998-03-11

    申请人： John M. Greene ,  Ewen F. Kirkness ,  Craig A. Rosen

    发明人： John M. Greene ,  Ewen F. Kirkness ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/10 ,  C12N15/54 ,  C12N15/63 ,  C12N15/79

    CPC分类号： C12N9/1085 ,  C12Y205/01029 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： A human geranylgeranyl pyrophosphate synthetase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for controlling morphology of cells. Antagonist against such polypeptides and their use as a therapeutic to treat cancer is also disclosed. Diagnostic assays are also disclosed which detect the presence of a mutated form of hGGPS and over-expression of the hGGPS protein.

    摘要翻译： 公开了人类香叶基香叶基焦磷酸合成酶多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来控制细胞形态的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗癌症治疗剂的用途。 还公开了诊断测定法，其检测突变形式的hGGPS的存在和hGGPS蛋白的过表达。

    Human geranylgeranyl pyrophosphate synthethase
    10.
    发明授权
    Human geranylgeranyl pyrophosphate synthethase 失效
    人类香叶基香叶基焦磷酸合成酶

    公开(公告)号：US5786193A

    公开(公告)日：1998-07-28

    申请号：US469665

    申请日：1995-06-06

    申请人： John M. Greene ,  Ewen F. Kirkness ,  Craig A. Rosen

    发明人： John M. Greene ,  Ewen F. Kirkness ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/10 ,  C12N15/54 ,  C12N15/63 ,  C12N15/79

    CPC分类号： C12N9/1085 ,  C12Y205/01029 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： A human geranylgeranyl pyrophosphate synthetase polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for controlling morphology of cells. Antagonist against such polypeptides and their use as a therapeutic to treat cancer is also disclosed. Diagnostic assays are also disclosed which detect the presence of a mutated form of hGGPS and over-expression of the hGGPS protein.

    摘要翻译： 公开了人类香叶基香叶基焦磷酸合成酶多肽和编码这种多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来控制细胞形态的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗癌症治疗剂的用途。 还公开了诊断测定法，其检测突变形式的hGGPS的存在和hGGPS蛋白的过表达。