-
公开(公告)号：US20060257858A1
公开(公告)日：2006-11-16
申请号：US11396287
申请日：2006-03-31
申请人： Henry Chiou , Alfred Sundquist , Weixing Chen , Paul Cizdiel
发明人： Henry Chiou , Alfred Sundquist , Weixing Chen , Paul Cizdiel
CPC分类号： C12N15/87 , B01J19/0046 , B01J2219/00315 , B01J2219/00387 , B01J2219/00527 , B01J2219/00592 , B01J2219/00596 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , C12N2799/021
摘要： The invention relates to methods for introducing target biopolymers (e.g., nucleic acid molecules, proteins, etc.) and other compounds (e.g., non-polymeric organic molecules, such as steroids) into cells (e.g., eukaryotic cells). The invention further relates to compositions comprising target biopolymers and other compounds. In certain aspects, the invention relates to the deposition of target biopolymer-containing mixtures onto surfaces optionally followed by contacting these target biopolymer-containing mixtures with cells (e.g., eukaryotic cells). Additionally, when the target biopolymers are nucleic acid molecules, expression of these nucleic acid molecules by cells which are contacted with the target biopolymers may be monitored or detected.
摘要翻译： 本发明涉及将靶生物聚合物（例如，核酸分子，蛋白质等）和其它化合物（例如非聚合有机分子，例如类固醇）引入细胞（例如真核细胞）的方法。 本发明还涉及包含靶生物聚合物和其它化合物的组合物。 在某些方面，本发明涉及将含目标生物聚合物的混合物沉积在表面上，任选地随后将这些含目标生物聚合物的混合物与细胞（例如真核细胞）接触。 另外，当目标生物聚合物是核酸分子时，可以监测或检测这些与目标生物聚合物接触的细胞的这些核酸分子的表达。
-
公开(公告)号：US20060228406A1
公开(公告)日：2006-10-12
申请号：US11384178
申请日：2006-03-17
申请人： Henry Chiou , Charles Shevlin
发明人： Henry Chiou , Charles Shevlin
CPC分类号： A61K9/1272 , A61K48/0041 , C12N15/88
摘要： The present invention discloses liposomal transfection reagents for delivery of macromolecules and other compounds into cells, particularly non-adherent suspension cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
摘要翻译： 本发明公开了用于将大分子和其它化合物递送到细胞，特别是非粘附悬浮细胞中的脂质体转染试剂。 它们对细胞的DNA依赖性转化特别有用。 还公开了其制备和用作细胞内递送剂的方法。
-
搜索结果
2 条记录 (耗时 0.018 秒)
