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27 条记录 (耗时 0.028 秒)

    Compositions using cycloalkano-quinolone derivatives and their method of use
    3.
    发明授权
    Compositions using cycloalkano-quinolone derivatives and their method of use 失效
    使用环烷 - 喹诺酮衍生物的组合物及其使用方法

    公开(公告)号：US4049811A

    公开(公告)日：1977-09-20

    申请号：US676269

    申请日：1976-04-12

    申请人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

    发明人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

    IPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16 ,  A61K31/47

    CPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16

    摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1##wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

    摘要翻译： 具有以下结构式表征的抗微生物活性的环烷醇 - 喹诺酮衍生物：其中R 1和R 2之一表示氢，卤素，硝基，氨基，羟基，酰氨基，酰氧基，烷氧基或芳氧基，另一个与R 3一起形成 含有2至6个碳原子的亚烷基桥，X是氢，可以被卤素，羟基，酰氧基，烷氧基，芳氧基，芳烷氧基，巯基，烷基巯基，芳基巯基，芳基磺酰基和烷基磺酰基中的成员所取代的低级烷基 或X为未取代的烯基，包括链二烯基或炔基，Y为羟基，氨基或低级烷氧基，及其药学上可接受的盐。

    Nitroimidazolyl-triazolo-pyridazine compounds
    5.
    发明授权
    Nitroimidazolyl-triazolo-pyridazine compounds 失效
    硝基咪唑基 - 三唑并 - 哒嗪化合物

    公开(公告)号：US4006141A

    公开(公告)日：1977-02-01

    申请号：US601116

    申请日：1975-07-31

    申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

    发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

    摘要翻译： 具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪：其中R是氢或在2-位被羟基或低级酰氧基或低级烷氧基任选取代的低级烷基; A是氢，卤素，叠氮基，氰基; 低级烷基烷氧基，烷硫基，烷基磺酰基，羧基; 低级烷氧基羰基，低级烷氧羰基亚氨基; 或肼基，氨基甲酰基，脒基或任选被一个或两个低级酰基，烷基或环烷基取代的碳代酰肼基; 或者A是下式的基团：其中R 1和R 2分别是氢或多个有机基团，或者一起可以是亚烷基桥; 并且R 3是氢或低级烷基; 或者与R 2一起形成亚烷基桥; N IS 0或1; 并且与药物相容，作为抗病毒药物具有高度的生物有效性。

    Combating bacteria with nitroimidazolyl-triazolo-pyridiazine compounds
    7.
    发明授权
    Combating bacteria with nitroimidazolyl-triazolo-pyridiazine compounds 失效
    抗菌与硝基咪唑基 - 三唑并 - 嘧啶化合物

    公开(公告)号：US3989832A

    公开(公告)日：1976-11-02

    申请号：US600533

    申请日：1975-07-31

    申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

    发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

    IPC分类号： C07D487/04 ,  A01N9/00 ,  A01N9/22

    CPC分类号： C07D487/04

    摘要： Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##SPC1##Wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl, alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

    摘要翻译： 具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪

    3-Alkyl-4-sulfamoyl-aniline therapeutic compositions
    8.
    发明授权
    3-Alkyl-4-sulfamoyl-aniline therapeutic compositions 失效
    3-烷基-4-氨磺酰基 - 苯胺治疗组合物

    公开(公告)号：US3991188A

    公开(公告)日：1976-11-09

    申请号：US593089

    申请日：1975-07-03

    申请人： Ansgar Lerch ,  Alfred Popelak ,  Kurt Stach ,  Egon Roesch ,  Klaus Hardebeck

    发明人： Ansgar Lerch ,  Alfred Popelak ,  Kurt Stach ,  Egon Roesch ,  Klaus Hardebeck

    IPC分类号： A61K31/63 ,  A61K31/625

    CPC分类号： A61K31/63 ,  Y10S514/869

    摘要： New 3-alkyl-4-sulfamoyl-aniline compounds of the formula ##SPC1##WhereinR.sub.1 is phenyl, furyl or thienyl;R.sub.2 is carboxyl or tetrazolyl-(5)R.sub.4 is a straight-chain or branched alkyl radical of from 2 to 5 carbon atoms; andn is 1 or 2;And the pharmacologically compatible salts thereof; are outstandingly effective saluretic compounds, particularly when administered enterally.

    摘要翻译： 式WHEREIN R1的新的3-烷基-4-氨磺酰基 - 苯胺化合物是苯基，呋喃基或噻吩基; R2是羧基或四唑基 - （5）R4是2至5个碳原子的直链或支链烷基; 和N IS 1 OR 2; 及其药理学兼容性; 具有非常有效的挥发性化合物，特别是在进行管理时尤其如此。