公开(公告)号：US3957766A

公开(公告)日：1976-05-18

申请号：US290682

申请日：1972-09-20

申请人： Herbert Berger ,  Rudi Gall ,  Hartmut Merdes ,  Kurt Stach ,  Winfriede Sauer ,  Wolfgang Vomel

发明人： Herbert Berger ,  Rudi Gall ,  Hartmut Merdes ,  Kurt Stach ,  Winfriede Sauer ,  Wolfgang Vomel

IPC分类号： C07D487/04 ,  C07D295/06 ,  C07D295/12 ,  C07D471/04

CPC分类号： C07D487/04

摘要： Certain novel nitrofuran compounds of the formula: ##SPC1##WhereinHet is an aromatic heterocylic linkage;B is a bond or vinylene;Y is O or S;m is 0 or 1;X is hydrogen, lower alkyl or alkanoyl; andThe R's are variously defined;Are outstandingly effective bacteriostats and bactericides.

公开(公告)号：US3995040A

公开(公告)日：1976-11-30

申请号：US595929

申请日：1975-07-14

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##SPC1##WhereinR is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 式WHEREIN R的新的环戊烯 - 喹诺酮衍生物是饱和或不饱和的脂族烃基，例如烷基和烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代或取代的（ 例如烷基单取代或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US3962242A

公开(公告)日：1976-06-08

申请号：US545661

申请日：1975-01-30

申请人： Herbert Berger ,  Rudi Gall ,  Max Thiel ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Rudi Gall ,  Max Thiel ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D487/04 ,  C07D237/26

CPC分类号： C07D487/04

摘要： Nitrofuryl-triazolo[4,3-b]pyridazine compounds of the formula ##SPC1##WhereinR.sub.1 is lower alkoxy radical or a saturated 5- or 6-membered heterocyclic ring attached via a cyclic nitrogen atom, which heterocyclic ring can also contain, in addition to said cyclic nitrogen atom, a cyclic oxygen atom or an optionally lower alkylated cyclic nitrogen atom and R.sub.2 is a hydrogen atom or R.sub.1 and R.sub.2 together represent an additional valency bond,Are outstandingly effective as bacteriostats and are particularly useful in the treatment of bacterial infections in the urinary tract.

公开(公告)号：US4033967A

公开(公告)日：1977-07-05

申请号：US515790

申请日：1974-10-17

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D215/20 ,  A61K31/473 ,  C07D215/06 ,  C07D215/233 ,  C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US3988460A

公开(公告)日：1976-10-26

申请号：US558101

申请日：1975-03-13

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, executor ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： A61K31/47

CPC分类号： A61K31/47

摘要： Certain novel cyclopentenoquinolone derivatives of the formula: ##SPC1##WhereinR and X, which may be the same or different, are hydrogen or lower saturated or unsaturated aliphatic hydrocarbyl;Y is hydroxyl or lower alkoxy or lower acyloxy (i.e., alkanoyloxy); andZ is hydrogen or lower alkoxy, or, together with Y, represents an oxo or lower alkenyldioxy radical; and the pharmacologically compatibile salts thereofAre outstandingly effective as anti-microbials, particularly for applications against infections of the urinary tract.

摘要翻译： 某些新的环戊烯喹诺酮衍生物，其结构如下：

公开(公告)号：US4049811A

公开(公告)日：1977-09-20

申请号：US676269

申请日：1976-04-12

申请人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16 ,  A61K31/47

CPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16

摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1##wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

摘要翻译： 具有以下结构式表征的抗微生物活性的环烷醇 - 喹诺酮衍生物：其中R 1和R 2之一表示氢，卤素，硝基，氨基，羟基，酰氨基，酰氧基，烷氧基或芳氧基，另一个与R 3一起形成 含有2至6个碳原子的亚烷基桥，X是氢，可以被卤素，羟基，酰氧基，烷氧基，芳氧基，芳烷氧基，巯基，烷基巯基，芳基巯基，芳基磺酰基和烷基磺酰基中的成员所取代的低级烷基 或X为未取代的烯基，包括链二烯基或炔基，Y为羟基，氨基或低级烷氧基，及其药学上可接受的盐。

公开(公告)号：US4034096A

公开(公告)日：1977-07-05

申请号：US595953

申请日：1975-07-14

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  by Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US3966743A

公开(公告)日：1976-06-29

申请号：US504589

申请日：1974-09-09

申请人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Herbert Berger ,  Alfred Rhomberg ,  Kurt Stach ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D221/08 ,  C07D221/10 ,  C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16 ,  C07D221/08 ,  C07D221/10

摘要： Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##SPC1##Wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an akylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

摘要翻译： 具有抗细菌活性的环烷醇 - 喹诺酮衍生物，其特征在于下式：

公开(公告)号：US4006141A

公开(公告)日：1977-02-01

申请号：US601116

申请日：1975-07-31

申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

摘要翻译： 具有下式的硝基咪唑基-s-三唑并[4,3-b]哒嗪：其中R是氢或在2-位被羟基或低级酰氧基或低级烷氧基任选取代的低级烷基; A是氢，卤素，叠氮基，氰基; 低级烷基烷氧基，烷硫基，烷基磺酰基，羧基; 低级烷氧基羰基，低级烷氧羰基亚氨基; 或肼基，氨基甲酰基，脒基或任选被一个或两个低级酰基，烷基或环烷基取代的碳代酰肼基; 或者A是下式的基团：其中R 1和R 2分别是氢或多个有机基团，或者一起可以是亚烷基桥; 并且R 3是氢或低级烷基; 或者与R 2一起形成亚烷基桥; N IS 0或1; 并且与药物相容，作为抗病毒药物具有高度的生物有效性。

公开(公告)号：US3948912A

公开(公告)日：1976-04-06

申请号：US559285

申请日：1975-03-17

申请人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

发明人： Herbert Berger ,  Rudi Gall ,  Kurt Stach ,  Wolfgang Vomel ,  Rita Hoffmann

IPC分类号： C07D403/14 ,  A61K31/5025 ,  C07D487/04 ,  C07D237/26

CPC分类号： C07D487/04

摘要： New nitroimidazolyl-triazolo-pyridazines of the formula: ##SPC1##WhereinZ is methyl or amino which can be substituted by lower alkyl,And the pharmacologically compatible acid-addition salts thereof, exhibit outstanding anti-microbial activity against bacteria and protozoa, and also systemic effectiveness.

摘要翻译： 新的具有下式的硝基咪唑基 - 三唑并 - 哒嗪：