公开(公告)号：US07358227B2

公开(公告)日：2008-04-15

申请号：US11346673

申请日：2006-02-03

申请人： Hermann Sailer ,  Franz Weber

发明人： Hermann Sailer ,  Franz Weber

IPC分类号： A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  C07K14/51

CPC分类号： A61K38/1875

摘要： The present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of recombinant bone morphogenic proteins (rBMPs) and its use in therapy, especially in the treatment of orthopaedic and dental patients. Specifically, the present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of at least two rBMPs or their monomers or mutants in a suitable carrier system.

摘要翻译： 本发明涉及包含重组骨形态发生蛋白（rBMP）的稳定折叠变体的混合物的药物组合物及其在治疗中的用途，特别是在矫形和牙科患者的治疗中。 具体地说，本发明涉及含有至少两种rBMP的稳定折叠变体或其单体或突变体在合适载体体系中的混合物的药物组合物。

公开(公告)号：US20060147534A1

公开(公告)日：2006-07-06

申请号：US11346673

申请日：2006-02-03

申请人： Hermann Sailer ,  Franz Weber

发明人： Hermann Sailer ,  Franz Weber

IPC分类号： A61K38/18 ,  A61K9/14

CPC分类号： A61K38/1875

摘要： The present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of recombinant bone morphogenic proteins (rBMPs) and its use in therapy, especially in the treatment of orthopaedic and dental patients. Specifically, the present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of at least two rBMPs or their monomers or mutants in a suitable carrier system.

摘要翻译： 本发明涉及包含重组骨形态发生蛋白（rBMP）的稳定折叠变体的混合物的药物组合物及其在治疗中的用途，特别是在矫形和牙科患者的治疗中。 具体地说，本发明涉及含有至少两种rBMP的稳定折叠变体或其单体或突变体在合适载体体系中的混合物的药物组合物。

公开(公告)号：US07041645B2

公开(公告)日：2006-05-09

申请号：US10189302

申请日：2002-07-02

申请人： Hermann Sailer ,  Franz Weber

发明人： Hermann Sailer ,  Franz Weber

IPC分类号： A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19

CPC分类号： A61K38/1875

摘要： The present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of recombinant bone morphogenic proteins (rBMPs) and its use in therapy, especially in the treatment of orthopaedic and dental patients. Specifically, the present invention relates to a pharmaceutical composition containing a mixture of stable folding variants of at least two rBMPs or their monomers or mutants in a suitable carrier system.

公开(公告)号：US08046383B2

公开(公告)日：2011-10-25

申请号：US11923095

申请日：2007-10-24

申请人： Franz Weber ,  Soeren Balko ,  Matthias Miltz

发明人： Franz Weber ,  Soeren Balko ,  Matthias Miltz

IPC分类号： G06F17/30

CPC分类号： G06F17/30914

摘要： Methods and apparatus, including computer program products, for mapping deep structured data structures. Statements defining a mapping of source elements formatted in accordance with a first hierarchical structure to a target formatted in accordance with a second hierarchical structure are received. The first and second hierarchical structures may be different. A mapping of the source elements to the target in accordance with the statements may be performed, where the statement may be defined in accordance with a mapping language. The mapping language may define that a single statement may represent an iterative approach to mapping elements from the source to the target. The mapping language may support selection of source elements using a format that allows for navigation through a hierarchy of the source. The mapping language may also support nested statements which may allow for nested iterations in which to perform mappings.

摘要翻译： 用于映射深层结构化数据结构的方法和设备，包括计算机程序产品。 接收将根据第一分层结构格式化的源元素的映射定义为根据第二层次结构格式化的目标的语句。 第一和第二层次结构可以不同。 可以执行根据语句的源元素到目标的映射，其中语句可以根据映射语言来定义。 映射语言可以定义单个语句可以表示将元素从源映射到目标的迭代方法。 映射语言可以支持使用允许通过源的层次结构进行导航的格式来选择源元素。 映射语言还可以支持嵌套语句，这些语句可能允许进行映射的嵌套迭代。

公开(公告)号：US07783714B2

公开(公告)日：2010-08-24

申请号：US12003102

申请日：2007-12-20

申请人： Roman Hayer ,  Bernhard Brinkmoeller ,  Franz Weber ,  Volker Wiechers ,  Thea Hillenbrand

发明人： Roman Hayer ,  Bernhard Brinkmoeller ,  Franz Weber ,  Volker Wiechers ,  Thea Hillenbrand

IPC分类号： G06F15/16

CPC分类号： G06Q10/10 ,  G06Q20/10 ,  H04L67/10

摘要： Methods and systems consistent with the invention manage messages transported between a first computer system and a second computer system. For instance, in one embodiment, According to another exemplary embodiment, a method obtains a business object identifier that identifies a business object associated with a first message to be transported over a network from the first computer system to the second computer system. The method may then generate a transport identifier associated with the transported message. The method may then route the first message the second computer system, such that the routing generates a second message that is transported to the second computer system. The method then obtains the second message transported to the second computer system. Finally, the method creates a data structure in memory including the transport identifier, the business object identifier, and the second message.

摘要翻译： 与本发明一致的方法和系统管理在第一计算机系统和第二计算机系统之间传送的消息。 例如，在一个实施例中，根据另一示例性实施例，一种方法获得业务对象标识符，该业务对象标识符识别与要通过网络从第一计算机系统传输到第二计算机系统的第一消息相关联的业务对象。 该方法然后可以生成与传送的消息相关联的传输标识符。 该方法然后可以将第一消息路由到第二计算机系统，使得路由生成被传送到第二计算机系统的第二消息。 该方法然后获得传送到第二计算机系统的第二消息。 最后，该方法在存储器中创建数据结构，包括传输标识符，业务对象标识符和第二消息。

公开(公告)号：US20080214763A1

公开(公告)日：2008-09-04

申请号：US12089539

申请日：2006-10-10

申请人： Volker Seidl ,  Carolin Nadine Ducker ,  Alexandra Wiedemann ,  Thomas Wettling ,  Uwe Rachwalsky ,  Marco-Christian Volland ,  Martin Karches ,  Franz Weber ,  Dieter Stutzer ,  Werner Bochnitschek

发明人： Volker Seidl ,  Carolin Nadine Ducker ,  Alexandra Wiedemann ,  Thomas Wettling ,  Uwe Rachwalsky ,  Marco-Christian Volland ,  Martin Karches ,  Franz Weber ,  Dieter Stutzer ,  Werner Bochnitschek

IPC分类号： C08F4/14

CPC分类号： C08F110/10 ,  C08F2/14 ,  C08F2500/01 ,  C08F2500/04

摘要： The present invention relates to a process for preparing polyisobutene by polymerizing isobutene using an inert diluent and a halogen-containing Lewis acid as a catalyst, wherein the isobutene in the form of droplets is contacted with the Lewis acid in a polymerization apparatus.

摘要翻译： 本发明涉及通过使用惰性稀释剂和含卤素的路易斯酸作为催化剂聚合异丁烯来制备聚异丁烯的方法，其中在聚合装置中使液滴形式的异丁烯与路易斯酸接触。

公开(公告)号：US20060270602A1

公开(公告)日：2006-11-30

申请号：US11452550

申请日：2006-06-14

申请人： Franz Weber

发明人： Franz Weber

IPC分类号： A61K38/18

CPC分类号： A61K38/1841 ,  A61K38/1875 ,  C07K14/51

摘要： The present invention relates to novel mutants of bone morphogenetic proteins (BMPs) useful as inhibitors of heterotopic ossification. Specifically, the present invention relates to novel mutants containing only the entire region involved in the formation of finger 2 including the wrist epitope of a BMP with a specific cysteine residue or specific cysteine residues replaced by a different amino acid. The present invention also relates pharmaceutical compositions containing these mutants and to the use of the mutants and pharmaceutical compositions in therapy.

公开(公告)号：US08374987B2

公开(公告)日：2013-02-12

申请号：US12165417

申请日：2008-06-30

申请人： Franz Weber ,  Matthias Miltz ,  Soeren Balko ,  Andreas Buchen

发明人： Franz Weber ,  Matthias Miltz ,  Soeren Balko ,  Andreas Buchen

IPC分类号： G06N5/02

CPC分类号： G06N5/025 ,  G06Q10/06

摘要： Methods and apparatus, including computer program products, related to stateful, continuous evaluation of event-condition-action rules by a state correlation engine. In general, one or more events may be determined to have occurred and an event-condition-action cycle may be caused to be processed for the events. The event-condition-action cycle may include evaluating condition networks based on a state of execution of the state correlation engine that includes the events, where the state of execution is based on a state of execution before the events, and enabling the actions to be executed if evaluation of the condition networks with the state of execution is to result in one or more actions being enabled.

摘要翻译： 方法和设备，包括计算机程序产品，与国家相关引擎的有状态，事件状态动作规则的连续评估有关。 通常，可以确定一个或多个事件已经发生，并且可以对事件进行事件 - 条件动作循环的处理。 事件状态动作循环可以包括基于包括事件的状态关联引擎的执行状态来评估条件网络，其中执行状态基于事件之前的执行状态，并且使得动作成为 如果对具有执行状态的条件网络的评估是导致一个或多个动作被启用，则执行。

公开(公告)号：US20090164985A1

公开(公告)日：2009-06-25

申请号：US11963817

申请日：2007-12-22

申请人： Soeren Balko ,  Franz Weber ,  Matthias Miltz

发明人： Soeren Balko ,  Franz Weber ,  Matthias Miltz

IPC分类号： G06F9/44

CPC分类号： G06Q10/0633 ,  G06F8/00 ,  G06Q10/06

摘要： Methods and apparatus, including computer program products, for compiling workflows into instructions for a state correlation engine. In general, data characterizing a workflow of a process is received and a network representation of event-condition-action rules representing the workflow is generated. The workflow of the process may be modeled in accordance with a notation similar to the Business Process Modeling Notation. The network representation of event-condition-action rules may include a combination of source nodes representing events, operator nodes representing conditions, and action nodes representing transactions. Events of the source nodes may be represented types of objects of a type language, where a correlation engine is to execute an event-condition-action rule based on an existence of a combination of types of a rule.

摘要翻译： 方法和装置，包括计算机程序产品，用于将工作流编译成状态关联引擎的指令。 通常，接收表征进程的工作流的数据，并且生成表示工作流的事件 - 条件动作规则的网络表示。 流程的工作流程可以按照与业务流程建模符号类似的符号进行建模。 事件条件动作规则的网络表示可以包括表示事件的源节点，表示条件的操作员节点和表示事务的动作节点的组合。 源节点的事件可以表示类型语言的对象的类型，其中相关引擎将基于规则的类型的组合的存在来执行事件条件动作规则。

公开(公告)号：US20090164548A1

公开(公告)日：2009-06-25

申请号：US12003102

申请日：2007-12-20

申请人： Roman Hayer ,  Bernhard Brinkmoeller ,  Franz Weber ,  Volker Wiechers ,  Thea Hillenbrand

发明人： Roman Hayer ,  Bernhard Brinkmoeller ,  Franz Weber ,  Volker Wiechers ,  Thea Hillenbrand

IPC分类号： G06F7/06 ,  G06F17/30 ,  G06F15/16

CPC分类号： G06Q10/10 ,  G06Q20/10 ,  H04L67/10

摘要： Methods and systems consistent with the invention manage messages transported between a first computer system and a second computer system. For instance, in one embodiment, According to another exemplary embodiment, a method obtains a business object identifier that identifies a business object associated with a first message to be transported over a network from the first computer system to the second computer system. The method may then generate a transport identifier associated with the transported message. The method may then route the first message the second computer system, such that the routing generates a second message that is transported to the second computer system. The method then obtains the second message transported to the second computer system. Finally, the method creates a data structure in memory including the transport identifier, the business object identifier, and the second message.

摘要翻译： 与本发明一致的方法和系统管理在第一计算机系统和第二计算机系统之间传送的消息。 例如，在一个实施例中，根据另一示例性实施例，一种方法获得业务对象标识符，该业务对象标识符识别与要通过网络从第一计算机系统传输到第二计算机系统的第一消息相关联的业务对象。 该方法然后可以生成与传送的消息相关联的传输标识符。 该方法然后可以将第一消息路由到第二计算机系统，使得路由生成被传送到第二计算机系统的第二消息。 该方法然后获得传送到第二计算机系统的第二消息。 最后，该方法在存储器中创建数据结构，包括传输标识符，业务对象标识符和第二消息。