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公开(公告)号：US20050042664A1
公开(公告)日：2005-02-24
申请号：US10923068
申请日：2004-08-20
CPC分类号： C07K16/465
摘要： The present invention provides methods of re-engineering or re-shaping an antibody from a first species, wherein the re-engineered or re-shaped antibody does not elicit undesired immune response in a second species, and the re-engineered or re-shaped antibody retains substantially the same antigen binding-ability of the antibody from the first species. In accordance with the present invention, a combinatorial library comprising the CDRs of the antibody from the first species fused in frame with framework regions derived from a second species can be constructed and screened for the desired modified antibody. In particular, the present invention provides methods utilizing low homology acceptor antibody frameworks for efficiently humanizing an antibody or a fragment thereof. The present invention also provides antibodies produced by the methods of the invention.
摘要翻译： 本发明提供了重新设计或重新形成来自第一种类的抗体的方法，其中重新设计或重新形成的抗体在第二种物种中不引发不期望的免疫应答，并且重新设计或重新形成 抗体保留了来自第一物种的抗体基本相同的抗原结合能力。 根据本发明，可以构建包含来自与来自第二种类的框架区域框架融合的第一物种的抗体的CDR的组合文库，并筛选所需的修饰抗体。 特别地，本发明提供利用低同源受体抗体框架有效地使抗体或其片段人源化的方法。 本发明还提供通过本发明的方法制备的抗体。
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公开(公告)号：US20060228350A1
公开(公告)日：2006-10-12
申请号：US11377148
申请日：2006-03-17
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/44 , C12N5/06
CPC分类号： C07K16/005 , C07H21/04 , C07K16/2863 , C07K16/40 , C07K16/464 , C07K2317/55 , C07K2317/92 , C12N15/1027
摘要： The present invention relates to methods of reengineering or reshaping antibodies to reduce the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing antibodies immunospecific for an antigen by synthesizing a combinatorial library comprising complementarity determining regions (CDRs) from a donor antibody fused in frame to framework regions from a sub-bank of framework regions. The invention also provides method of producing improved humanized antibodies. The present invention also provides antibodies produced by the methods of the invention.
摘要翻译： 本发明涉及重新设计或重塑抗体以降低抗体免疫原性的方法，同时保持针对抗原的抗体的免疫特异性。 特别地，本发明提供了通过合成包含来自框架区域的子库的框架区域融合的供体抗体的互补决定区（CDR）的组合文库的组合文库来产生针对抗原免疫特异性的抗体的方法。 本发明还提供了生产改良的人源化抗体的方法。 本发明还提供通过本发明的方法制备的抗体。
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公开(公告)号：US20100216975A1
公开(公告)日：2010-08-26
申请号：US12697597
申请日：2010-02-01
CPC分类号： C07K16/005 , C07H21/04 , C07K16/2863 , C07K16/40 , C07K16/464 , C07K2317/55 , C07K2317/92 , C12N15/1027
摘要： The present invention relates to methods of reengineering or reshaping antibodies to reduce the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing antibodies immunospecific for an antigen by synthesizing a combinatorial library comprising complementarity determining regions (CDRs) from a donor antibody fused in frame to framework regions from a sub-bank of framework regions. The invention also provides method of producing improved humanized antibodies. The present invention also provides antibodies produced by the methods of the invention.
摘要翻译： 本发明涉及重新设计或重塑抗体以降低抗体免疫原性的方法，同时保持针对抗原的抗体的免疫特异性。 特别地，本发明提供了通过合成包含来自框架区域的子库的框架区域融合的供体抗体的互补决定区（CDR）的组合文库的组合文库来产生针对抗原免疫特异性的抗体的方法。 本发明还提供了生产改良的人源化抗体的方法。 本发明还提供通过本发明的方法制备的抗体。
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公开(公告)号：US20050048617A1
公开(公告)日：2005-03-03
申请号：US10920899
申请日：2004-08-18
CPC分类号： C07K16/005 , C07H21/04 , C07K16/40 , C12N15/1037 , C12Q2563/131
摘要： The present invention relates to methods of reengineering or reshaping antibodies to reduce the immunogenicity of the antibodies, while maintaining the immunospecificity of the antibodies for an antigen. In particular, the present invention provides methods of producing antibodies immunospecific for an antigen by synthesizing a combinatorial library comprising complementarity determining regions (CDRs) from a donor antibody fused in frame to framework regions from a sub-bank of framework regions. The present invention also provides antibodies produced by the methods of the invention.
摘要翻译： 本发明涉及重新设计或重塑抗体以降低抗体免疫原性的方法，同时保持针对抗原的抗体的免疫特异性。 特别地，本发明提供了通过合成包含来自框架区域的子库的框架区域融合的供体抗体的互补决定区（CDR）的组合文库的组合文库来产生针对抗原免疫特异性的抗体的方法。 本发明还提供通过本发明的方法制备的抗体。
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公开(公告)号：US20080181887A1
公开(公告)日：2008-07-31
申请号：US11762525
申请日：2007-06-13
申请人： William Dall-Acqua , Herren Wu , Peter Kiener
发明人： William Dall-Acqua , Herren Wu , Peter Kiener
IPC分类号： A61K39/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/1027 , C07K2317/52 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention provides molecules, including IgGs, non-IgG immunoglobulin, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.
摘要翻译： 本发明提供了由于存在IgG恒定结构域或其结合FcRn的部分而具有增加的体内半衰期的IgG，非IgG免疫球蛋白，蛋白质和非蛋白质试剂的分子，其具有一个 或更多的氨基酸修饰，其增加FcRn的恒定结构域或片段的亲和力。 具有增加的半衰期的这种蛋白质和分子具有在这种分子的治疗，预防或诊断使用中需要更少量和/或更低频率给药的优点。
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