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    OILY PACLITAXEL COMPOSITION AND FORMULATION FOR CHEMOEMBOLIZATION AND PREPARATION METHOD THEREOF
    4.
    发明申请
    OILY PACLITAXEL COMPOSITION AND FORMULATION FOR CHEMOEMBOLIZATION AND PREPARATION METHOD THEREOF 审中-公开
    油酰胺组合物及其制备方法及其制备方法

    公开(公告)号：US20100041744A1

    公开(公告)日：2010-02-18

    申请号：US12540207

    申请日：2009-08-12

    申请人： Hesson Chung ,  Seo Young Jeong ,  Ick Chan Kwon ,  Yeong Taek Park ,  In Hyun Lee ,  Jae Hyung Park ,  Jin Wook Chung ,  Young Man Kim

    发明人： Hesson Chung ,  Seo Young Jeong ,  Ick Chan Kwon ,  Yeong Taek Park ,  In Hyun Lee ,  Jae Hyung Park ,  Jin Wook Chung ,  Young Man Kim

    IPC分类号： A61K31/337 ,  A61P35/00

    CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K47/44 ,  A61K49/0452

    摘要： Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof solubilizing paclitaxel in an oily contrast medium. The composition of the present invention solubilizes paclitaxel and has an advantage of delivering anticancer drug to the target cells by chemoembolization since it is possible to visualize the blood vessel during the chemoembolization process. The present invention also relates to oily paclitaxel composition and formulation additionally comprising chemicals that prevent paclitaxel precipitation for prolonged preservation and the preparation method thereof. Since the composition of the present invention solubilize paclitaxel effectively and can be visualized during chemoembolization, it can be used for TACE to treat hepatoma and other solid tumors.

    摘要翻译： 油性紫杉醇组合物和化疗栓塞制剂及其在油性造影剂中增溶紫杉醇的制备方法。 本发明的组合物溶解紫杉醇，并且具有通过化学栓塞将抗癌药物递送至靶细胞的优点，因为在化学栓塞过程中可以使血管可视化。 本发明还涉及另外包含防止紫杉醇沉淀用于延长保存的化学物质的油性紫杉醇组合物和制剂及其制备方法。 由于本发明的组合物有效地溶解紫杉醇并且可以在化学栓塞期间可视化，所以可用于TACE治疗肝癌和其他实体瘤。

    Mucoadhesive composition and formulation for solubilization of insoluble drugs and preparation method thereof
    5.
    发明申请
    Mucoadhesive composition and formulation for solubilization of insoluble drugs and preparation method thereof 审中-公开
    用于溶解不溶性药物的粘膜组合物和制剂及其制备方法

    公开(公告)号：US20060134144A1

    公开(公告)日：2006-06-22

    申请号：US10521989

    申请日：2003-07-21

    申请人： Hesson Chung ,  Seo-Young Jeong ,  Ick-Chan Kwon ,  Yeong-Taek Park ,  In-Hyun Lee

    发明人： Hesson Chung ,  Seo-Young Jeong ,  Ick-Chan Kwon ,  Yeong-Taek Park ,  In-Hyun Lee

    IPC分类号： A61K9/00 ,  A61K31/225

    CPC分类号： A61K9/006 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/225 ,  A61K47/14 ,  A61K47/44

    摘要： The present invention relates to a novel mucoadhesive composition for solubilization of insoluble drugs; its formulation including pharmaceutical compounds; and the preparation methods thereof wherein said solubilizing composition comprises 4˜90% by weight of at least one selected from the monoglycerides and 0.01˜90% by weight of at least one oil. The present invention relates to a novel mucoadhesive composition including pharmaceutical compounds; and the preparation methods thereof wherein said solubilizing composition including emulsifiers is composed of 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight, of at least one oil, and 0.01˜90% by weight of at least one selected from the emulsifiers. The compositions of the present invention is suitable as drug delivery systems since they exist as mucoadhesive liquid at physiological temperatures even though they exist as liquid or semi-solid at room temperature.

    摘要翻译： 本发明涉及一种用于溶解不溶性药物的新型粘膜粘附组合物， 其制剂包括药物化合物; 及其制备方法，其中所述增溶组合物包含4〜90重量％的选自单酸甘油酯和0.01〜90重量％的至少一种油的至少一种。 本发明涉及包含药物化合物的新型粘膜粘附组合物; 及其制备方法，其中所述包含乳化剂的增溶组合物由4〜90重量％的选自单酸甘油酯，0.01〜90重量％，至少1种油和0.01〜90重量％ 选自乳化剂中的至少一种。 本发明的组合物适合作为药物递送系统，因为它们在生理温度下作为粘膜粘附液体存在，即使它们在室温下以液体或半固体形式存在。

    Composition for solubilization of paclitaxel and preparation method thereof
    7.
    发明申请
    Composition for solubilization of paclitaxel and preparation method thereof 有权
    紫杉醇溶解组合物及其制备方法

    公开(公告)号：US20060104999A1

    公开(公告)日：2006-05-18

    申请号：US10521669

    申请日：2003-07-18

    申请人： Hesson Chung ,  Seo-Young Jeong ,  Ick-Chan Kwon ,  Yeong-Taek Park ,  In-Hyun Lee ,  Soon-Hong Yuk ,  Young-Wook Choi ,  Jae-Hyung Park ,  Jin-Wook Chung

    发明人： Hesson Chung ,  Seo-Young Jeong ,  Ick-Chan Kwon ,  Yeong-Taek Park ,  In-Hyun Lee ,  Soon-Hong Yuk ,  Young-Wook Choi ,  Jae-Hyung Park ,  Jin-Wook Chung

    IPC分类号： A61K9/00

    CPC分类号： A61K31/337 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/107 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K2300/00

    摘要： The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil and 0.01˜20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil, 0.01˜90% by weight of at least one emulsifier and 0.01˜20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.

    摘要翻译： 本发明涉及紫杉醇组合物及其制备方法，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油和0.01〜20重量％的至少一种 紫杉醇的重量％。 本发明还涉及包含乳化剂的紫杉醇组合物及其制备方法来溶解紫杉醇，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油， 0.01〜90重量％的至少一种乳化剂和0.01〜20重量％的紫杉醇。 本发明的组合物是有效的紫杉醇递送系统，因为组合物溶解紫杉醇，在分散于水中后不形成聚集体，在肠壁上吸附良好，因此具有高的生物利用度。

    Formulation solubilizing water-insoluble agents and preparation method thereof
    8.
    发明授权
    Formulation solubilizing water-insoluble agents and preparation method thereof 失效
    制剂增溶水不溶性物质及其制备方法

    公开(公告)号：US06994862B2

    公开(公告)日：2006-02-07

    申请号：US10221449

    申请日：2001-03-13

    申请人： Seo Young Jeong ,  Ick Chan Kwon ,  Hesson Chung

    发明人： Seo Young Jeong ,  Ick Chan Kwon ,  Hesson Chung

    IPC分类号： A61K7/00

    CPC分类号： A61K9/1075 ,  A61K9/19

    摘要： The present invention relates to an anhydrous liquid composition wherein monoglyceride is mixed with an emulsifier and a solvent, and the manufacturing method thereof, and more specifically, to an anhydrous liquid composition wherein monoglyceride is mixed with a water-insoluble material, an emulsifier and a solvent, and the manufacturing method thereof. Further, the present invention relates to a lyophilized powder and the manufacturing method thereof, wherein the lyophilized powder is prepared by dissolving the mixed liquid composition in water, adding with a cryoprotectant followed by the lyophilization. In the process of dispersion, the lyophilized liquid composition and the powder of the present invention can spontaneously generate particles of 200-500 nm by gently shaking with hands without a powerful mechanical force. Also the lyophilized liquid composition and the powder of the present invention are physicochemically stable since they neither contain water that causes oxidation or hydrolysis upon storage nor undergo phase separation. Considering all the raw materials of the present invention are biocompatible, the present invention will be useful in medical and pharmaceutical fields such as drug delivery.

    摘要翻译： 本发明涉及将单酸甘油酯与乳化剂和溶剂混合的无水液体组合物及其制造方法，更具体地，涉及将单酸甘油酯与水不溶性物质，乳化剂和 溶剂及其制造方法。 另外，本发明还涉及一种冻干粉末及其制造方法，其特征在于，所述冻干粉末是将所述混合液体组合物溶解在水中，加入冷冻保护剂后进行冻干。 在分散过程中，本发明的冻干液体组合物和粉末可以通过用手轻轻晃动而自发产生200-500nm的颗粒，而没有强大的机械力。 此外，冻干液体组合物和本发明的粉末在物理化学上是稳定的，因为它们既不含有在储存时引起氧化或水解的水也不经历相分离。 考虑到本发明的所有原料都是生物相容的，本发明可用于医药领域如药物递送。

    Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof
    10.
    发明授权
    Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof 失效
    形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法

    公开(公告)号：US07511023B2

    公开(公告)日：2009-03-31

    申请号：US10473629

    申请日：2002-08-14

    申请人： Ick Chan Kwon ,  In-San Kim ,  Seo Young Jeong ,  Hesson Chung ,  Yong Woo Cho ,  Yoen Ju Son ,  Chong Rae Park ,  Sang Bong Seo

    发明人： Ick Chan Kwon ,  In-San Kim ,  Seo Young Jeong ,  Hesson Chung ,  Yong Woo Cho ,  Yoen Ju Son ,  Chong Rae Park ,  Sang Bong Seo

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/704 ,  A61K47/61 ,  A61K47/6907

    摘要： The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed of a hydrophobic anticancer agent and a hydrophilic chitosan, and the preparation method thereof. The anticancer drug-chitosan complex of the present invention not only works selectively against target tumor tissue but also continues to release the medicine over a long period of time. Besides, the anticancer drug-chitosan complex could have greater amount of drug by adding the anticancer drug into self-aggregates, which is generally limited by chemical bond. Therefore, the anticancer drug-chitosan complex of the present invention can be effectively used for the cancer chemotherapy.

    摘要翻译： 本发明涉及形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。 更准确地说，本发明涉及在由疏水性抗癌剂和亲水性壳聚糖组成的水性介质中形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。 本发明的抗癌药物 - 壳聚糖复合物不仅对目标肿瘤组织有选择性的作用，而且还能够长时间地释放药物。 此外，抗癌药物 - 壳聚糖复合物可以通过将抗癌药物加入自聚集体中而具有更大量的药物，其通常受化学键的限制。 因此，本发明的抗癌药物 - 壳聚糖复合物可以有效地用于癌症化疗。