公开(公告)号：US5109197A

公开(公告)日：1992-04-28

申请号：US578766

申请日：1990-09-07

申请人： Takashi Onodera ,  Hidemi Shiono ,  Hideki Kohno

发明人： Takashi Onodera ,  Hidemi Shiono ,  Hideki Kohno

IPC分类号： A61B5/055 ,  G01R33/48 ,  G01R33/565

CPC分类号： G01R33/56554

摘要： A nuclear magnetic resonance multi-echo imaging method and an apparatus therefor in which gradient field pulses having predetermined products of intensity and time are applied on both sides of an inversion pulse in at least two of three directions which are orthogonal to each other to dephase components of a magnetization vector which leads to an artifact signal and an error signal, whereby only a normal echo signal can be sampled to form a correct image.

公开(公告)号：US4937201A

公开(公告)日：1990-06-26

申请号：US495487

申请日：1983-05-17

申请人： Kazue Ueno ,  Hideki Kohno ,  Satoshi Tsutsui

发明人： Kazue Ueno ,  Hideki Kohno ,  Satoshi Tsutsui

IPC分类号： G01N33/543 ,  G01N33/569

CPC分类号： G01N33/54393 ,  G01N33/54313 ,  G01N33/56916 ,  Y10S435/842

摘要： Latex particles are sensitized with Immunoglobulin G obtained from the antiserum collected from a laboratory animal which has been immunized with a toxin extracted from pathogenic enterobacterium. The IgG-sensitized latex is useful for diagnosis of diseases caused by pathogenic enterobacteria.

摘要翻译： 用从用从病原性肠杆菌提取的毒素免疫的实验室动物中收集的抗血清获得的免疫球蛋白G使乳胶颗粒致敏。 IgG致敏乳胶可用于诊断由致病肠杆菌引起的疾病。

公开(公告)号：US4791369A

公开(公告)日：1988-12-13

申请号：US72035

申请日：1987-07-10

申请人： Etsuji Yamamoto ,  Hideki Kohno

发明人： Etsuji Yamamoto ,  Hideki Kohno

IPC分类号： A61B5/055 ,  A61B10/00 ,  G01R33/24 ,  G01R33/48 ,  G01R33/565 ,  G01R33/20

CPC分类号： G01R33/24 ,  G01R33/56563 ,  G01R33/56518

摘要： A method of finding error distribution in the static magnetic field and distribution of deviations from straight lines in the gradient magnetic fields of an NMR imaging apparatus which employs the applied spin-warp method. A phantom whose shape has been known is measured in the read-out gradient magnetic fields having different polarities to obtain two spin density distribution images. The two images are then compared with the shape of said phantom to measure the distortion distributions of the images. Error in the static magnetic field and deviations of the gradient magnetic fields from the straight lines are analyzed from the distortion distributions. From the thus obtained error distribution, furthermore, distortion induced in imaging the object is estimated, and the distortion contained in the image that is reconstructed from the spin density of the object by the spin-warp method is corrected using the thus estimated value.

摘要翻译： 在使用所采用的旋转翘曲方法的NMR成像装置的梯度磁场中找到静态磁场中的误差分布和偏离直线偏差的方法。 在具有不同极性的读出梯度磁场中测量其形状已知的体模，以获得两个自旋密度分布图像。 然后将两个图像与所述体模的形状进行比较，以测量图像的失真分布。 从失真分布中分析静态磁场的误差和梯度磁场与直线的偏差。 此外，根据这样得到的误差分布，估计在物体成像时引起的失真，并且使用这样估计的值来校正通过旋转扭曲方法从物体的自旋密度重构的图像中包含的失真。

公开(公告)号：US4777443A

公开(公告)日：1988-10-11

申请号：US119489

申请日：1987-11-12

申请人： Masao Yabusaki ,  Etsuji Yamamoto ,  Takashi Onodera ,  Yukiko Ogura ,  Hideaki Nakane ,  Shigeru Matsui ,  Hideki Kohno

发明人： Masao Yabusaki ,  Etsuji Yamamoto ,  Takashi Onodera ,  Yukiko Ogura ,  Hideaki Nakane ,  Shigeru Matsui ,  Hideki Kohno

IPC分类号： G01R33/035 ,  G01R33/36 ,  G01R33/20

CPC分类号： G01R33/326 ,  G01R33/0358

摘要： Disclosed in a nuclear magnetic resonance (NMR) based inspection apparatus using an SQUID flux meter for detecting a small NMR signal, in which a receiving coil for receiving the NMR signal from an object is connected to a mixer, which mixes a reference high-frequency signal with the NMR signal so that the NMR signal is reduced to a low-frequency signal having a differential component of frequencies of both signals, and the low-frequency signal is applied to the input coil of the SQUID flux meter so that it is converted into a voltage signal. The mixer circuit includes Schottky diodes operative at a liquid helium temperature or Josephson junctions, and the portions of apparatus from the reception coil up to the SQUID flux meter are operated in a superconductive state at a liquid helium temperature.

摘要翻译： 在使用SQUID通量计检测小型NMR信号的基于核磁共振（NMR）的检查装置中公开了一种用于从物体接收NMR信号的接收线圈连接到混频器，该混频器将参考高频 用NMR信号进行信号，使得NMR信号被减少到具有两个信号的频率的差分分量的低频信号，并且低频信号被施加到SQUID通量计的输入线圈，使得其被转换 变成电压信号。 混频器电路包括以液氦温度或约瑟夫逊结操作的肖特基二极管，并且从接收线圈到SQUID通量计的装置部分在液氦温度下处于超导状态。

公开(公告)号：US4689568A

公开(公告)日：1987-08-25

申请号：US750475

申请日：1985-07-01

申请人： Shigeru Matsui ,  Kensuke Sekihara ,  Hideki Kohno ,  Takashi Onodera ,  Hidemi Shiono

发明人： Shigeru Matsui ,  Kensuke Sekihara ,  Hideki Kohno ,  Takashi Onodera ,  Hidemi Shiono

IPC分类号： G01R33/44 ,  A61B5/055 ,  A61B10/00 ,  G01R33/48 ,  G01R33/485 ,  G01R33/561 ,  G01R33/20

CPC分类号： G01R33/485 ,  G01R33/5616

摘要： An NMR imaging method which provides a three-dimensional image representative of the two-dimensional distribution of nuclear spin species resolved by chemical shift or the local spectra resolved by two-dimensional location. After the excitation of nuclear spins and the phase-encoding by application of a field gradient G.sub.y, a periodically inverting field gradient G.sub.x is generated to yield a continuous echo train. The echo train is sampled and separated into data of odd-numbered echoes and data of even-numbered echoes which data are in turn reconstructed into two-dimensional data arrays, respectively. The data thus reconstructed are three-dimensional Fourier-transformed.

摘要翻译： 提供表示通过化学位移分解的核自旋物质的二维分布的三维图像的NMR成像方法或通过二维位置解析的局部光谱。 在核自旋的激励和通过施加场梯度Gy的相位编码之后，产生周期性反转场梯度Gx以产生连续的回波串。 回波串被采样并分离成奇数回波的数据和偶数回波的数据，数据又分别被重建成二维数据阵列。 这样重建的数据是三维傅里叶变换的。

公开(公告)号：US4683433A

公开(公告)日：1987-07-28

申请号：US636995

申请日：1984-08-02

申请人： Etsuji Yamamoto ,  Hideki Kohno ,  Masao Kuroda ,  Shigeru Matsui ,  Hidemi Shiono

发明人： Etsuji Yamamoto ,  Hideki Kohno ,  Masao Kuroda ,  Shigeru Matsui ,  Hidemi Shiono

IPC分类号： G01R33/20 ,  A61B5/055 ,  A61B10/00 ,  G01R33/48 ,  G01R33/54 ,  G01R33/56

CPC分类号： G01R33/482 ,  G01R33/56

摘要： An NMR imaging apparatus and method for detecting a nuclear spin resonance signal from an object, which is placed in a magnetic field, to produce images of the object. At an instant when the spins come into phase after the signal detection by a first spin excitation, RF magnetic field pulses are applied for rotating the direction of the spin to that opposite to the initial state. After that, the spin excitation and the signal direction of second time are conducted to measure the data which are different in the effect of the relaxation time from the first measurements. By repeating these sequences, it is possible to produce a plurality of images such as an intensity image or a relaxation time enhanced image.

摘要翻译： 一种用于检测放置在磁场中的物体的核自旋共振信号的NMR成像设备和方法，以产生物体的图像。 在通过第一自旋激发在信号检测之后自旋进入相位的瞬间，施加RF磁场脉冲以将旋转方向旋转到与初始状态相反的方向。 之后，进行自旋激励和第二次的信号方向，以测量与第一次测量相比，松弛时间的影响不同的数据。 通过重复这些序列，可以产生多个图像，例如强度图像或弛豫时间增强图像。

公开(公告)号：US4625170A

公开(公告)日：1986-11-25

申请号：US635154

申请日：1984-07-27

申请人： Etsuji Yamamoto ,  Shigeru Matsui ,  Masuo Kuroda ,  Hideki Kohno

发明人： Etsuji Yamamoto ,  Shigeru Matsui ,  Masuo Kuroda ,  Hideki Kohno

IPC分类号： G01R33/20 ,  A61B5/055 ,  A61B10/00 ,  G01R33/48 ,  G01R33/565

CPC分类号： G01R33/56518

摘要： An NMR imaging method and apparatus of the type in which a 180-degree RF pulse is applied to generate a spin echo after the selective excitation of a spin by a 90-degree RF pulse. A dummy gradient field, which has the same direction and intensity as those of a gradient field to be applied when the spin echo is observed, is applied between said 90-degree RF pulse and said 180-degree RF pulse so that the instant of starting the application of the gradient field for signal observation is advanced to the extent corresponding to said dummy gradient field.

摘要翻译： 一种NMR成像方法和装置，其中施加180度RF脉冲以在旋转选择性激发90度RF脉冲之后产生自旋回波。 在所述90度RF脉冲和所述180度RF脉冲之间，施加与观察到自旋回波时要施加的梯度场相同的方向和强度的虚拟梯度场，使得起始时刻 将用于信号观察的梯度场的应用提前到对应于所述虚拟梯度场的程度。

公开(公告)号：US4607164A

公开(公告)日：1986-08-19

申请号：US517402

申请日：1983-07-26

申请人： Shigeo Kubota ,  Minoru Yoshida ,  Toshio Takahashi ,  Hideki Kohno ,  Takayuki Hayakawa ,  Sadao Matuoka ,  Shigeo Kato ,  Takaji Suzuki

发明人： Shigeo Kubota ,  Minoru Yoshida ,  Toshio Takahashi ,  Hideki Kohno ,  Takayuki Hayakawa ,  Sadao Matuoka ,  Shigeo Kato ,  Takaji Suzuki

IPC分类号： G01T1/164 ,  G01T1/20 ,  G01T1/202

CPC分类号： G01T1/202 ,  G01T1/1644 ,  G01T1/2018

摘要： A radiation detecting apparatus includes a pair of substrates disposed face to face in such a manner that a plurality of grooves provided in one of the facing surfaces at a predetermined interval face a plurality of grooves provided in the other of the facing surfaces at the predetermined interval. Radiation shielding plates are inserted at both ends thereof into a facing pair of grooves to be held by both of the substrates, scintillators are mounted on a corresponding one of the radiation shielding plates, and photodetectors are fixed to either one of the facing surfaces of the substrates between adjacent grooves so that a plurality of facing pairs of photodetectors are juxtaposed.

摘要翻译： 放射线检测装置包括一对基板，以这样一种方式设置，使得以预定间隔设置在一个相对表面中的多个凹槽面对设置在另一个相对表面中的预定间隔的多个凹槽 。 辐射屏蔽板的两端插入到由两个基板保持的面对的一对沟槽中，闪烁体安装在相应的一个辐射屏蔽板上，光电检测器固定在 相邻槽之间的衬底，使得多个面对的光电检测器对并置。

公开(公告)号：US4472683A

公开(公告)日：1984-09-18

申请号：US420303

申请日：1982-09-20

申请人： Kensuke Sekihara ,  Etsuji Yamamoto ,  Hideki Kohno ,  Shinji Yamamoto

发明人： Kensuke Sekihara ,  Etsuji Yamamoto ,  Hideki Kohno ,  Shinji Yamamoto

IPC分类号： A61B10/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/54 ,  G01R33/08

CPC分类号： G01R33/4833

摘要： An imaging apparatus using nuclear magnetic resonance is disclosed in which both an image corresponding to the projection of a nuclear spin distribution in a to-be-inspected object on a two-dimensional plane and a display mark indicating a desired measuring position are displayed on a display face of a display device such as a CRT display, the display mark is freely moved on the display face to be set at a desired position on the display face, and magnetic field generating means for generating a static magnetic field, linear gradient field, or radio frequency magnetic field is controlled on the basis of the desired position of the display mark to obtain an image of that cross section of the object which is located at a position indicated by the display mark.

摘要翻译： 公开了一种使用核磁共振的成像装置，其中在二维平面上的被检查物体中的核自旋分布的投影和指示期望的测量位置的显示标记的图像都显示在 CRT显示器等显示装置的显示面，在显示面上自由移动显示标记，将其设定在显示面上的期望位置，产生静磁场，线性梯度场， 或者基于显示标记的期望位置来控制射频磁场，以获得位于由显示标记指示的位置处的对象的该横截面的图像。

公开(公告)号：US5202269A

公开(公告)日：1993-04-13

申请号：US592612

申请日：1990-10-04

申请人： Michio Ito ,  Minoru Ogura ,  Hideki Kohno

发明人： Michio Ito ,  Minoru Ogura ,  Hideki Kohno

IPC分类号： G01N33/53 ,  G01N33/543

CPC分类号： G01N33/54313 ,  G01N33/54333 ,  Y10S436/817 ,  Y10S436/822

摘要： A method for immunochemical determination of a hapten in a sample is disclosed, in which(A) a high-molecular compound to which the hapten is bound (reagent A),(B) insoluble carrier particles carrying thereon an antibody to the hapten (reagent B), and(C) magnetic substance-containing insoluble carrier particles carrying thereon an antibody to an antigenic determinant in the high-molecular compound and different from the hapten (reagent C),are used. These three reagents are dispersed in the sample, then, a magnetic field is applied to separate from the reaction mixture unreacted reagent (C) and agglutinated particles formed from the reagent (B) and the reagent (C) through the reagent (A). The amount of the reagent (B) remaining dispersed in the reaction mixture is measured, thereby determining the extent of competitive inhibition to the agglutination of the reagent (B) and the reagent (C) through the reagent (A) by the reaction between the hapten in the sample and the reagent (B). The method of the present invention requires no troublesome operations such as separation-washing and is free from any problem is safety. By the method of the present invention, the concentration of a hapten in a sample is determined by simple operations in a short time and with high sensitivity.