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    POLYPEPTIDE MARKER FOR DIAGNOSIS OF ARTERIOSCLEROSIS, METHOD FOR DETECTION OF ARTERIOSCLEROSIS BY USING THE MAKER OR THE LIKE, AND KIT FOR DIAGNOSIS OF ARTERIOSCLEROSIS
    2.
    发明申请
    POLYPEPTIDE MARKER FOR DIAGNOSIS OF ARTERIOSCLEROSIS, METHOD FOR DETECTION OF ARTERIOSCLEROSIS BY USING THE MAKER OR THE LIKE, AND KIT FOR DIAGNOSIS OF ARTERIOSCLEROSIS 审中-公开
    用于诊断病原体的多肽标记物，使用制造商或类似物检测肠梗塞的方法以及用于诊断椎间盘菌的试剂盒

    公开(公告)号：US20110287955A1

    公开(公告)日：2011-11-24

    申请号：US13058456

    申请日：2009-08-14

    申请人： Rika Nakamura ,  Hideyuki Kuroda ,  Go Tomiyoshi ,  Takaki Hiwasa ,  Masaki Takiguchi ,  Naokatsu Saeki ,  Toshio Machida

    发明人： Rika Nakamura ,  Hideyuki Kuroda ,  Go Tomiyoshi ,  Takaki Hiwasa ,  Masaki Takiguchi ,  Naokatsu Saeki ,  Toshio Machida

    IPC分类号： C40B30/04 ,  C40B40/06 ,  C07K14/435 ,  C12Q1/68 ,  C07K16/18 ,  C07H21/04 ,  G01N33/566

    CPC分类号： G01N33/6893 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/323

    摘要： Disclosed are: a polypeptide marker for diagnosing arteriosclerosis; a gene marker for diagnosing arteriosclerosis; an antibody; a probe for detecting an arteriosclerosis marker gene; a DNA microarray or a DNA chip for detecting an arteriosclerosis marker gene; a method for detecting arteriosclerosis; and a kit for diagnosing arteriosclerosis; with which an arteriosclerotic lesion can be detected with much improved accuracy. Specifically disclosed are: a polypeptide marker for diagnosing arteriosclerosis, which comprises a polypeptide having an amino acid sequence set forth in any one of SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, and 35 of the Sequence Listing, or a partial amino acid sequence thereof; a gene which encodes the amino acid sequence; a probe for detecting the gene; a DNA microarray or a DNA chip comprising the probe; an antibody bindable to the polypeptide as an antigen; a kit comprising any one of the above-mentioned items; and a method for detecting arteriosclerosis by using any one of the above-mentioned items.

    摘要翻译： 公开了用于诊断动脉硬化的多肽标记物; 用于诊断动脉硬化的基因标记物; 抗体; 用于检测动脉硬化标志物基因的探针; 用于检测动脉硬化标志物基因的DNA微阵列或DNA芯片; 检测动脉硬化的方法; 和用于诊断动脉硬化的试剂盒; 可以以更高的精度检测动脉硬化病变。 具体公开的是：用于诊断动脉硬化的多肽标记物，其包含具有SEQ ID NO：1,3,5,7,9,11,13,15,17,19， 21,23,25,27,29,31,33和35，或其部分氨基酸序列; 编码氨基酸序列的基因; 用于检测基因的探针; DNA微阵列或包含探针的DNA芯片; 可与该多肽结合的抗体作为抗原; 一个包括上述任何项目的工具包; 以及通过使用上述任一个项目来检测动脉硬化的方法。

    Brain tumor marker and method of diagnosing brain tumor
    3.
    发明申请
    Brain tumor marker and method of diagnosing brain tumor 审中-公开
    脑肿瘤标志物和诊断脑肿瘤的方法

    公开(公告)号：US20070122810A1

    公开(公告)日：2007-05-31

    申请号：US10569732

    申请日：2004-04-30

    申请人： Yasuo Iwadate ,  Takaki Hiwasa ,  Masaki Takiguchi ,  Akira Yamaura

    发明人： Yasuo Iwadate ,  Takaki Hiwasa ,  Masaki Takiguchi ,  Akira Yamaura

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C07K14/82

    CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156 ,  G01N33/57407

    摘要： The present invention provides a brain tumor marker, characterized in that the brain tumor marker is at least one protein expressed in a brain tumor tissue and selected from the group of proteins having the amino acid sequences represented by SEQ ID NOS: 1 to 16, respectively, wherein the protein is expressed in at least one tissue selected from the group of the tissues of a highly malignant brain tumor, a low malignant brain tumor, a drug-sensitive brain tumor, and a drug-resistant brain tumor; a polynucleotide encoding the brain tumor marker; and a method of diagnosing brain tumors by using the brain tumor marker or the polynucleotide as an indicator.

    摘要翻译： 本发明提供一种脑肿瘤标志物，其特征在于，脑肿瘤标记物是至少一种在脑肿瘤组织中表达的蛋白质，分别选自具有SEQ ID NO：1至16所示氨基酸序列的蛋白质组 其中所述蛋白质在选自高恶性脑肿瘤，低恶性脑肿瘤，药物敏感性脑肿瘤和耐药性脑肿瘤的组织组中的至少一种组织中表达; 编码脑肿瘤标志物的多核苷酸; 以及通过使用脑肿瘤标记物或多核苷酸作为指标诊断脑肿瘤的方法。