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公开(公告)号：US20060241038A1
公开(公告)日：2006-10-26
申请号：US11111504
申请日：2005-04-20
IPC分类号： A61K38/54
CPC分类号： G01N33/5023 , A61K38/1709 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/5058 , G01N2333/4709 , G01N2800/2821
摘要： The present invention provides a pharmaceutical composition comprising at least one member selected from a compound capable of enhancing Aβ37 production, a compound capable of inhibiting Aβ40 and Aβ42 production and enhancing Aβ37 production, and salts of the compounds and hydrates thereof.
摘要翻译： 本发明提供一种药物组合物，其包含至少一种选自能够增强Abeta37产生的化合物，能够抑制Aβ42和Aβ42产生并增强Abeta37产生的化合物，以及其化合物及其水合物的盐。
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公开(公告)号：US09581604B2
公开(公告)日：2017-02-28
申请号：US13880475
申请日：2011-06-23
申请人： Yoshiaki Sato , Ken Aoshima , Francois Bernier
发明人： Yoshiaki Sato , Ken Aoshima , Francois Bernier
CPC分类号： G01N33/6896 , G01N33/92 , Y10T436/203332
摘要： Desmosterol alone, the combination of desmosterol and amyloid beta, the combination of desmosterol and gelsolin and the combination of desmosterol, amyloid beta and gelsolin can be used as in-blood biomarkers for Alzheimer's disease or mild cognitive impairment. A method for evaluating the effect of a candidate for a therapeutic agent to treat Alzheimer's disease or mild cognitive impairment, a method for aiding the diagnosis of Alzheimer's disease or mild cognitive impairment, and a method for diagnosing Alzheimer's disease or mild cognitive impairment are provided in which the biomarkers are used.
摘要翻译： 去头孢曲松单独使用，去头痛醇和淀粉样蛋白β的组合，去极化醇和凝溶胶蛋白的组合以及去极化醇，淀粉样蛋白β和凝溶胶蛋白的组合可用作阿尔茨海默氏病或轻度认知障碍的血液内生物标志物。 评估治疗剂候选者治疗阿尔茨海默氏病或轻度认知障碍的效果的方法，辅助诊断阿尔茨海默病或轻度认知障碍的方法以及诊断阿尔茨海默病或轻度认知障碍的方法 使用生物标志物。
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公开(公告)号：US20130266589A1
公开(公告)日：2013-10-10
申请号：US13880475
申请日：2011-06-23
申请人： Yoshiaki Sato , Ken Aoshima , Francois Bernier
发明人： Yoshiaki Sato , Ken Aoshima , Francois Bernier
CPC分类号： G01N33/6896 , G01N33/92 , Y10T436/203332
摘要： Desmosterol alone, the combination of desmosterol and amyloid beta, the combination of desmosterol and gelsolin and the combination of desmosterol, amyloid beta and gelsolin can be used as in-blood biomarkers for Alzheimer's disease or mild cognitive impairment. A method for evaluating the effect of a candidate for a therapeutic agent to treat Alzheimer's disease or mild cognitive impairment, a method for aiding the diagnosis of Alzheimer's disease or mild cognitive impairment, and a method for diagnosing Alzheimer's disease or mild cognitive impairment are provided in which the biomarkers are used.
摘要翻译： 去头孢曲松单独使用，去头痛醇和淀粉样蛋白β的组合，去极化醇和凝溶胶蛋白的组合以及去极化醇，淀粉样蛋白β和凝溶胶蛋白的组合可用作阿尔茨海默氏病或轻度认知障碍的血液内生物标志物。 评估治疗剂候选者治疗阿尔茨海默氏病或轻度认知障碍的效果的方法，辅助诊断阿尔茨海默病或轻度认知障碍的方法以及诊断阿尔茨海默病或轻度认知障碍的方法 使用生物标志物。
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公开(公告)号：US20110041572A1
公开(公告)日：2011-02-24
申请号：US12746824
申请日：2008-12-05
CPC分类号： E05B85/26 , E05B17/0004 , E05B63/0056 , Y10T29/49826 , Y10T70/5889
摘要： The invention relates to a method of manufacturing locks for doors of a plurality of models of motor vehicles, each lock comprising a latch (1) which is rotatable about an axis (A) and which is associated with a pawl (2) rotatable about an axis (B), and also a mechanical and/or electrical transmission arrangement for carrying out an identical list of commands, the positioning of the fastening points (3, 4, 5) of these locks being identical, and the relative positioning of their “S point” (S1, S2) being different. According to the invention, said mechanical and/or electrical transmission arrangement of each of the locks is identical and only the assembly consisting of the latch and the associated pawl is different for each model of vehicles, in order to achieve said positioning of the “S point”.
摘要翻译： 本发明涉及一种用于制造机动车辆的多个型号的门的锁的方法，每个锁包括可围绕轴线（A）旋转的闩锁（1），所述闩锁（1）可相对于可围绕 轴（B），以及用于执行相同的命令列表的机械和/或电气传动装置，这些锁的紧固点（3,4,5）的定位是相同的，并且它们的“ S点“（S1，S2）不同。 根据本发明，每个锁的所述机械和/或电气传动装置是相同的，并且只有由闩锁和相关联的棘爪组成的组件对于每种车辆型号是不同的，以便实现“S 点”。
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