公开(公告)号：US4777178A

公开(公告)日：1988-10-11

申请号：US870915

申请日：1986-06-05

申请人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

发明人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

IPC分类号： C07D211/14 ,  A61K31/44 ,  A61K31/445 ,  A61K31/451 ,  A61P9/04 ,  C07D211/70 ,  C07D277/04 ,  C07D417/12 ,  A61K31/425

CPC分类号： C07D417/12

摘要： A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, R.sup.2 is hydrogen or a lower alkyl group, R.sup.3 is hydrogen, a lower alkyl group or a lower alkanoyl group, Q is a single bond or a lower alkylene group, Alk is a lower alkylene group, Y and Z are the same or different and are oxygen atom or sulfur atom and the group of the formula: ##STR2## is either ##STR3## or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.

摘要翻译： 一种下式的噻唑烷衍生物：其中R1是取代或未取代的苯基，R2是氢或低级烷基，R3是氢，低级烷基或低级烷酰基，Q是 单键或低级亚烷基，Alk是低级亚烷基，Y和Z相同或不同，并且是氧原子或硫原子，并且下式的基团：或者是药学上可接受的盐 它们作为强心剂可以用于制备化合物的方法和含有所述化合物的药物组合物。

公开(公告)号：US4689327A

公开(公告)日：1987-08-25

申请号：US748394

申请日：1985-06-24

申请人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

发明人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

IPC分类号： C07D277/04 ,  A61K31/495 ,  C07D417/10

CPC分类号： C07D277/04

摘要： A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, Q is a single bond, a lower alkylene group or a lower alkenylene group, R.sup.2 and R.sup.3 are the same or different and each is hydrogen atom, a lower alkyl group, a cycloalkyl group, a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkylsulfonyl group, a benzoyl group, a phenyl group or a di(lower alkyl)phosphoryl group, Alk is a lower alkylene group, and Y and Z are the same or different and each is oxygen atom or sulfur atom, or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.

摘要翻译： 一种下式的噻唑烷衍生物：其中R1是取代或未取代的苯基，Q是单键，低级亚烷基或低级亚烯基，R2和R3相同或不同，各自相同或不同， 是低级烷基，环烷基，低级烷酰基，低级烷氧基羰基，低级烷基磺酰基，苯甲酰基，苯基或二（低级烷基）磷酰基，Alk是低级亚烷基 基团，Y和Z相同或不同，并且各自为氧原子或硫原子，或其药学上可接受的盐，其可用作强心剂与制备化合物的方法和含有 说化合物。