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16 条记录 (耗时 0.019 秒)

    N-substituted-2-[2-[2-(4-p henylpiperazine-1-yl)ethoxy]phenyl]-thiazolidine-3-carboxamides useful as cardiotonic agent
    1.
    发明授权
    N-substituted-2-[2-[2-(4-p henylpiperazine-1-yl)ethoxy]phenyl]-thiazolidine-3-carboxamides useful as cardiotonic agent 失效
    可用作强心剂的N-取代-2- [2- [2-（4-苯基哌嗪-1-基）乙氧基]苯基] - 噻唑烷-3-甲酰胺

    公开(公告)号：US4689327A

    公开(公告)日：1987-08-25

    申请号：US748394

    申请日：1985-06-24

    申请人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

    发明人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

    IPC分类号： C07D277/04 ,  A61K31/495 ,  C07D417/10

    CPC分类号： C07D277/04

    摘要： A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, Q is a single bond, a lower alkylene group or a lower alkenylene group, R.sup.2 and R.sup.3 are the same or different and each is hydrogen atom, a lower alkyl group, a cycloalkyl group, a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkylsulfonyl group, a benzoyl group, a phenyl group or a di(lower alkyl)phosphoryl group, Alk is a lower alkylene group, and Y and Z are the same or different and each is oxygen atom or sulfur atom, or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.

    摘要翻译： 一种下式的噻唑烷衍生物：其中R1是取代或未取代的苯基，Q是单键，低级亚烷基或低级亚烯基，R2和R3相同或不同，各自相同或不同， 是低级烷基，环烷基，低级烷酰基，低级烷氧基羰基，低级烷基磺酰基，苯甲酰基，苯基或二（低级烷基）磷酰基，Alk是低级亚烷基 基团，Y和Z相同或不同，并且各自为氧原子或硫原子，或其药学上可接受的盐，其可用作强心剂与制备化合物的方法和含有 说化合物。

    1,5-benzothiazepine derivative
    2.
    发明授权
    1,5-benzothiazepine derivative 失效
    1,5-苯并硫氮杂衍生物

    公开(公告)号：US4594342A

    公开(公告)日：1986-06-10

    申请号：US715115

    申请日：1985-03-22

    申请人： Mikio Takeda ,  Tokuro Oh-ishi ,  Hiromichi Nakajima ,  Taku Nagao

    发明人： Mikio Takeda ,  Tokuro Oh-ishi ,  Hiromichi Nakajima ,  Taku Nagao

    IPC分类号： C07D281/10 ,  A61K31/55

    CPC分类号： C07D281/10

    摘要： Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.4 are:(a) R.sup.1 is lower alkyl or lower alkoxy, and R.sup.4 is lower alkyl, lower alkoxy, fluorine, benzyloxy, hydroxy or lower alkylthio, or(b) R.sup.1 is lower alkyl, and R.sup.4 is hydrogen, or(c) R.sup.1 is hydroxy, and R.sup.4 is lower alkyl, fluorine, hydroxy or lower alkylthio;R.sup.2 is hydrogen, lower alkanoyl or benzoyl; and R.sup.3 is lower alkyl; and a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt have a potent platelet aggregation-inhibiting activity.

    摘要翻译： 下式的新的1,5-苯并硫氮杂衍生物：其中R 1和R 4是：（a）R 1是低级烷基或低级烷氧基，R 4是低级烷基，低级烷氧基，氟，苄氧基，羟基或低级 或（b）R1为低级烷基，R4为氢，或（c）R1为羟基，R4为低级烷基，氟，羟基或低级烷硫基; R2是氢，低级烷酰基或苯甲酰基; 并且R 3是低级烷基; 及其药学上可接受的酸加成盐。 所述衍生物（I）及其盐具有有效的血小板聚集抑制活性。

    1,5-benzothiazepine derivatives and preparation thereof
    5.
    发明授权
    1,5-benzothiazepine derivatives and preparation thereof 失效
    1,5-苯并噻吩衍生物及其制备方法

    公开(公告)号：US5134139A

    公开(公告)日：1992-07-28

    申请号：US570625

    申请日：1990-08-21

    申请人： Akiyoshi Kawai ,  Hirozumi Inoue ,  Hiroshi Narita ,  Taku Nagao

    发明人： Akiyoshi Kawai ,  Hirozumi Inoue ,  Hiroshi Narita ,  Taku Nagao

    IPC分类号： A61K31/55 ,  A61K31/554 ,  A61P3/00 ,  A61P3/14 ,  A61P9/00 ,  C07D281/10 ,  C07D417/12

    CPC分类号： C07D417/12 ,  C07D281/10

    摘要： Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein X is hydrogen atom, a halogen atom or a lower alkyl group; R.sup.1 is a lower alkyl group or a lower alkoxy group; R.sup.2 is hydrogen atom, a lower alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenyl-lower alkyl grup or a diphenyl-lower alkyl group; R.sup.3 is a lower alkyl group or a substituted or unsubstituted phenyl-lower alkyl group, Q is single bond, or an alkylene or lower alkenylene group which may optionally be substituted by a lower alkoxy group or oxo group; R.sup.4 is (i) hydrogen atom, (ii) a lower alkyl group, (iii) an N-phenyl-N-lower alkylamino group, (iv) a phenyl, phenyloxy, phenylthio, benzenesulfonylamino, 1,4-benzoquinonyl or benzylthio group which may optionally have substituent, or (v) a heterocyclic group which may optionally have substituent; and n is 2 or 3, or a pharmaceutically acceptable salt thereof, which are useful as a calcium antagonist, and the process for preparing thereof.

    Thiazolidine derivatives
    6.
    发明授权
    Thiazolidine derivatives 失效
    噻唑烷衍生物

    公开(公告)号：US4777178A

    公开(公告)日：1988-10-11

    申请号：US870915

    申请日：1986-06-05

    申请人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

    发明人： Hideo Nakai ,  Hiroshi Wada ,  Taku Nagao ,  Hideo Yabana

    IPC分类号： C07D211/14 ,  A61K31/44 ,  A61K31/445 ,  A61K31/451 ,  A61P9/04 ,  C07D211/70 ,  C07D277/04 ,  C07D417/12 ,  A61K31/425

    CPC分类号： C07D417/12

    摘要： A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, R.sup.2 is hydrogen or a lower alkyl group, R.sup.3 is hydrogen, a lower alkyl group or a lower alkanoyl group, Q is a single bond or a lower alkylene group, Alk is a lower alkylene group, Y and Z are the same or different and are oxygen atom or sulfur atom and the group of the formula: ##STR2## is either ##STR3## or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.

    摘要翻译： 一种下式的噻唑烷衍生物：其中R1是取代或未取代的苯基，R2是氢或低级烷基，R3是氢，低级烷基或低级烷酰基，Q是 单键或低级亚烷基，Alk是低级亚烷基，Y和Z相同或不同，并且是氧原子或硫原子，并且下式的基团：或者是药学上可接受的盐 它们作为强心剂可以用于制备化合物的方法和含有所述化合物的药物组合物。

    1,5-benzothiazepine derivatives and their pharmaceutical use
    7.
    发明授权
    1,5-benzothiazepine derivatives and their pharmaceutical use 失效
    1,5-苯并硫氮杂衍生物及其药物用途

    公开(公告)号：US4590188A

    公开(公告)日：1986-05-20

    申请号：US698125

    申请日：1985-02-04

    申请人： Mikio Takeda ,  Tokuro Oh-ishi ,  Hiromichi Nakajima ,  Taku Nagao

    发明人： Mikio Takeda ,  Tokuro Oh-ishi ,  Hiromichi Nakajima ,  Taku Nagao

    IPC分类号： C07D281/10 ,  A61K31/55

    CPC分类号： C07D281/10

    摘要： Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 is lower alkyl or lower alkoxy, R.sup.2 is hydrogen atom or lower alkanoyl, each one of R.sup.3 and R.sup.4 is lower alkyl, Ring A is a substituted benzene ring of the formula: ##STR2## R.sup.a is lower alkyl, lower alkoxy, lower alkylthio or benzyloxy, each one of R.sup.b and R.sup.c is lower alkyl, lower alkoxy or halogen atom, and either one of R.sup.d and R.sup.e is fluorine atom and the other one is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt are useful as a hypotensive agent and/or a cerebral or coronary vasodilator.

    摘要翻译： 下式的新的1,5-苯并硫氮杂衍生物：其中R 1是低级烷基或低级烷氧基，R 2是氢原子或低级烷酰基，R 3和R 4各自是低级烷基，环A是取代苯 下式的环：R a是低级烷基，低级烷氧基，低级烷硫基或苄氧基，R b和R c中的每一个是低级烷基，低级烷氧基或卤素原子，Rd和Re中的任一个是氟原子，而另一个 一个是氢原子，或其药学上可接受的酸加成盐。 所述衍生物（I）及其盐可用作降压剂和/或脑或冠状血管扩张剂。