公开(公告)号：US09044520B2

公开(公告)日：2015-06-02

申请号：US13434722

申请日：2012-03-29

申请人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

发明人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K51/08

CPC分类号： A61K51/088 ,  G01N2800/042

摘要： Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.

摘要翻译： 本发明的实施方案提供了一种在炎症部位中积聚的化合物，含有标记状态的化合物的诊断剂及其用于标记的前体化合物。 Z-Y-Leu-Phe-（X）n-DLys（ - （DLys）m-HalB） - （DLys）k-NH 2（1）的化合物可以由下述式（1）表示： ）其中在式（1）中，Z表示氨基的保护基; Y表示Met或Nle; X表示由一种或多种氨基酸和/或合成有机化合物组成的间隔物; n表示1或0; m表示1或0; k表示1或0; HalB表示在芳香环中具有放射性卤素的取代苯甲酸。

公开(公告)号：US20120330024A1

公开(公告)日：2012-12-27

申请号：US13582047

申请日：2011-02-24

申请人： Hideo Saji ,  Masahiro Ono ,  Ikuya Seki

发明人： Hideo Saji ,  Masahiro Ono ,  Ikuya Seki

IPC分类号： C07D405/06 ,  C07F7/22 ,  C07D405/14 ,  C07D417/06 ,  C07D417/14

CPC分类号： C07D417/06 ,  A61K51/0453 ,  C07D405/06 ,  C07D405/14

摘要： The present invention is a compound represented by the following formula (1) or a salt thereof. Furthermore, the present invention is an imaging agent used for imaging a tau protein, the imaging agent containing a compound represented by the formula (1) below or a salt thereof. In the formula (1), R3 is a radioactive iodine.

摘要翻译： 本发明是由下式（1）表示的化合物或其盐。 此外，本发明是用于成像tau蛋白的成像剂，该成像剂含有下述式（1）表示的化合物或其盐。 在式（1）中，R 3是放射性碘。

公开(公告)号：US20120253010A1

公开(公告)日：2012-10-04

申请号：US13434722

申请日：2012-03-29

申请人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

发明人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

IPC分类号： C07K7/06

CPC分类号： A61K51/088 ,  G01N2800/042

摘要： Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.

摘要翻译： 本发明的实施方案提供了一种在炎症部位中积聚的化合物，含有标记状态的化合物的诊断剂及其用于标记的前体化合物。 Z-Y-Leu-Phe-（X）n-DLys（ - （DLys）m-HalB） - （DLys）k-NH 2（1）的化合物可以由下述式（1）表示： ）其中在式（1）中，Z表示氨基的保护基; Y表示Met或Nle; X表示由一种或多种氨基酸和/或合成有机化合物组成的间隔物; n表示1或0; m表示1或0; k表示1或0; HalB表示在芳香环中具有放射性卤素的取代苯甲酸。

公开(公告)号：US08476449B2

公开(公告)日：2013-07-02

申请号：US13582047

申请日：2011-02-24

申请人： Hideo Saji ,  Masahiro Ono ,  Ikuya Seki

发明人： Hideo Saji ,  Masahiro Ono ,  Ikuya Seki

IPC分类号： C07D405/06 ,  C07D405/14 ,  C07D417/06 ,  C07D417/14 ,  C07F7/22

CPC分类号： C07D417/06 ,  A61K51/0453 ,  C07D405/06 ,  C07D405/14

摘要： The present invention is a compound represented by the following formula (1) or a salt thereof. Furthermore, the present invention is an imaging agent used for imaging a tau protein, the imaging agent containing a compound represented by the formula (1) below or a salt thereof. In the formula (1), R3 is a radioactive iodine.

摘要翻译： 本发明是由下式（1）表示的化合物或其盐。 此外，本发明是用于成像tau蛋白的成像剂，该成像剂含有下述式（1）表示的化合物或其盐。 在式（1）中，R 3是放射性碘。

公开(公告)号：US09370589B2

公开(公告)日：2016-06-21

申请号：US13818392

申请日：2011-08-08

申请人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

发明人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

IPC分类号： A61K9/14 ,  A61K49/00

CPC分类号： A61K49/0089 ,  A61K49/0032 ,  A61K49/0093 ,  Y10S977/773 ,  Y10S977/927

摘要： The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

摘要翻译： 本发明提供了具有开关功能（在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能）的新型荧光纳米颗粒成像探针。 一种开关荧光纳米颗粒探针，包括：由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含： 必需的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是由式（I）表示的花青化合物：和 荧光染料被封装在单分子组装中。

公开(公告)号：US20130149252A1

公开(公告)日：2013-06-13

申请号：US13818392

申请日：2011-08-08

申请人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

发明人： Isao Hara ,  Eiichi Ozeki ,  Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma

IPC分类号： A61K49/00

CPC分类号： A61K49/0089 ,  A61K49/0032 ,  A61K49/0093 ,  Y10S977/773 ,  Y10S977/927

摘要： The present invention provides a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye during nanoparticle preparation, and emit fluorescence during imaging). A switching fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the molecular assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a cyanine compound represented by the formula (I): and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

摘要翻译： 本发明提供了具有开关功能（在纳米颗粒制备期间淬灭荧光染料并在成像期间发射荧光的功能）的新型荧光纳米颗粒成像探针。 一种开关荧光纳米颗粒探针，包括：由具有亲水嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在分子组合中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含： 必需的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是由式（I）表示的花青化合物：和 荧光染料被封装在单分子组装中。

公开(公告)号：US09849197B2

公开(公告)日：2017-12-26

申请号：US14002327

申请日：2012-03-01

申请人： Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma ,  Isao Hara ,  Eiichi Ozeki

发明人： Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma ,  Isao Hara ,  Eiichi Ozeki

IPC分类号： A61K9/00 ,  A61K49/00

CPC分类号： A61K49/0054 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0069 ,  A61K49/0093

摘要： [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged).[Solution] A fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a polylactic acid-bound cyanine compound comprising: a fluorescent group represented by the formula (I): and a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

公开(公告)号：US20130336896A1

公开(公告)日：2013-12-19

申请号：US14002327

申请日：2012-03-01

申请人： Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma ,  Isao Hara ,  Eiichi Ozeki

发明人： Hideo Saji ,  Shunsaku Kimura ,  Masahiro Ono ,  Takashi Temma ,  Isao Hara ,  Eiichi Ozeki

IPC分类号： A61K49/00

CPC分类号： A61K49/0054 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0069 ,  A61K49/0093

摘要： [Problem] To provide a novel fluorescent nanoparticle imaging probe having a switching function (a function to quench a fluorescent dye in a blood component and emit fluorescence in a tumor or an inflamed site to be imaged).[Solution] A fluorescent nanoparticle probe comprising: a molecular assembly composed of an amphiphilic block polymer having a hydrophilic block chain and a hydrophobic block chain; and a fluorescent dye encapsulated in the assembly, wherein (a) the hydrophilic block chain comprises, as an essential hydrophilic structural unit, a unit selected from a sarcosine unit and an alkylene oxide unit, (b) the hydrophobic block chain comprises, as an essential hydrophobic structural unit, a unit selected from the group consisting of an amino acid unit and a hydroxylic acid unit, and (c) the fluorescent dye is a polylactic acid-bound cyanine compound comprising: a fluorescent group represented by the formula (I): and a polylactic acid group having 5 to 50 lactic acid units, and two or more molecules of the fluorescent dye are encapsulated in the single molecular assembly.

摘要翻译： [问题]提供具有切换功能（在血液成分中淬灭荧光染料并在肿瘤中发射荧光或成像的发炎部位的功能）的新型荧光纳米粒子成像探针。 [解决方案]荧光纳米颗粒探针，其包含：由具有亲水性嵌段链和疏水性嵌段链的两亲嵌段聚合物组成的分子组合; 以及包封在所述组件中的荧光染料，其中（a）所述亲水性嵌段链包含作为必需亲水性结构单元的选自肌氨酸单元和烯化氧单元的单元，（b）所述疏水性嵌段链包含作为 必要的疏水结构单元，选自氨基酸单元和羟基酸单元的单元，和（c）荧光染料是聚乳酸结合的花青化合物，包括：由式（I）表示的荧光基团， 和具有5〜50个乳酸单元的聚乳酸基团和2个以上的荧光染料分子被包封在单分子组装体中。

公开(公告)号：US10566165B2

公开(公告)日：2020-02-18

申请号：US13880282

申请日：2012-05-25

申请人： Masahiro Ono ,  Takashi Nakagawa ,  Akira Takano

发明人： Masahiro Ono ,  Takashi Nakagawa ,  Akira Takano

IPC分类号： H01H85/00 ,  H01H69/02 ,  H01H85/12 ,  H01H85/02 ,  H01M2/30 ,  H01M10/42 ,  H01M2/34 ,  H01H85/20 ,  H01H85/143

摘要： A fuse board including a metal plate, a connection portion connected to a cell, a fuse portion connecting the metal plate to the connection portion, and an insulating resin film bonded to the fuse portion, wherein a wiring pattern of the fuse portion has a bent portion, and the insulating resin film has a rectangular sheet-like shape that covers one surface of the fuse portion.

公开(公告)号：US20140302724A1

公开(公告)日：2014-10-09

申请号：US14123285

申请日：2012-03-14

申请人： Masahiro Ono

发明人： Masahiro Ono

IPC分类号： H01R13/42

CPC分类号： H01R13/42 ,  H01R13/4364 ,  H01R13/502 ,  H01R24/86

摘要： A connector, including a plug terminal of a plug connected to a first electric signal line and inserted in a terminal hole of a plug body, a socket terminal of a socket connected to a second electric signal line and inserted in a terminal hole of a socket body, a plug holder of the plug, and a socket holder of the socket, where the plug holder and the socket holder are connected to each other, where the plug terminal is press fitted in and electrically connected to the socket terminal, where a position in an axial center direction is controlled by sandwiching one end portion of at least one of the plug terminal and the socket terminal between the body and a terminal holder made of an insulating material.

摘要翻译： 一种连接器，包括连接到第一电信号线并插入插头主体的端子孔中的插头的插头端子，插座的插座端子连接到第二电信号线并插入插座的端子孔中 主体，插头的插头座和插座的插座座，其中插头保持器和插座保持器彼此连接，其中插头端子被压配合并电连接到插座端子，其中位置 通过将插头端子和插座端子中的至少一个的一个端部夹在主体和由绝缘材料制成的端子座之间来控制轴向中心方向。