公开(公告)号：US20070093676A1

公开(公告)日：2007-04-26

申请号：US10567900

申请日：2005-12-19

申请人： Hidetaka Kojima ,  Hiroyuki Miura

发明人： Hidetaka Kojima ,  Hiroyuki Miura

IPC分类号： C07C51/12

CPC分类号： B01J23/464 ,  B01J27/13 ,  C01B3/16 ,  C07C51/12 ,  Y02P20/52 ,  C07C53/08

摘要： A method produces acetic acid by continuously reacting methanol with carbon monoxide in the presence of a rhodium catalyst, an iodide salt, methyl iodide, methyl acetate, and water; and thereby producing acetic acid at a production rate of 11 mol/L·hr or more while keeping the acetaldehyde content of a reaction mixture to 500 ppm or less, in which the reaction is carried out at a carbon monoxide partial pressure in a gaseous phase of a reactor of 1.05 MPa or more and/or at a methyl acetate content of the reaction mixture of 2 percent by weight or more to thereby keep the production rate of acetaldehyde to 1/1500 or less that of acetic acid. This method can reduce production of by-products without reducing the reaction rate of acetic acid even at a low water content and a low hydrogen partial pressure in a reaction system.

摘要翻译： 一种方法是通过在铑催化剂，碘化物盐，甲基碘，乙酸甲酯和水的存在下，使甲醇与一氧化碳连续反应来生产乙酸; 从而在将反应混合物的乙醛含量保持在500ppm以下的条件下以11mol / L·hr或更高的生产速率生产乙酸，其中反应在气相中以一氧化碳分压进行 的反应混合物的1.05MPa以上和/或乙酸甲酯含量为2重量％以上，从而将乙醛的生成速度保持在乙酸的1/1500以下。 该方法即使在反应体系中的低水分含量和低的氢分压下也可以降低乙酸的反应速率而不降低副产物的产生。

公开(公告)号：US07683212B2

公开(公告)日：2010-03-23

申请号：US10567900

申请日：2005-12-19

申请人： Hidetaka Kojima ,  Hiroyuki Miura

发明人： Hidetaka Kojima ,  Hiroyuki Miura

IPC分类号： C07C51/12

CPC分类号： B01J23/464 ,  B01J27/13 ,  C01B3/16 ,  C07C51/12 ,  Y02P20/52 ,  C07C53/08

摘要： A method produces acetic acid by continuously reacting methanol with carbon monoxide in the presence of a rhodium catalyst, an iodide salt, methyl iodide, methyl acetate, and water; and thereby producing acetic acid at a production rate of 11 mol/L·hr or more while keeping the acetaldehyde content of a reaction mixture to 500 ppm or less, in which the reaction is carried out at a carbon monoxide partial pressure in a gaseous phase of a reactor of 1.05 MPa or more and/or at a methyl acetate content of the reaction mixture of 2 percent by weight or more to thereby keep the production rate of acetaldehyde to 1/1500 or less that of acetic acid. This method can reduce production of by-products without reducing the reaction rate of acetic acid even at a low water content and a low hydrogen partial pressure in a reaction system.

摘要翻译： 一种方法是通过在铑催化剂，碘化物盐，甲基碘，乙酸甲酯和水的存在下，使甲醇与一氧化碳连续反应来生产乙酸; 从而在将反应混合物的乙醛含量保持在500ppm以下的同时以11mol / L·hr以上的生产速度生产乙酸，其中反应在气相中以一氧化碳分压进行 的反应混合物的1.05MPa以上和/或乙酸甲酯含量为2重量％以上，从而将乙醛的生成速度保持在乙酸的1/1500以下。 该方法即使在反应体系中的低水分含量和低的氢分压下也可以降低乙酸的反应速率而不降低副产物的产生。

公开(公告)号：US07678940B2

公开(公告)日：2010-03-16

申请号：US11922339

申请日：2006-07-11

申请人： Hiroyuki Miura ,  Hidetaka Kojima

发明人： Hiroyuki Miura ,  Hidetaka Kojima

IPC分类号： C07C51/42

CPC分类号： C07C51/44 ,  C07C53/08 ,  C07C53/122

摘要： A process for producing a purified carboxylic acid having “n+1” carbon atoms comprises feeding a carboxylic acid stream containing a carboxylic acid having “n+1” carbon atoms, a hydrogen halide, a lower boiling point (bp) component, a higher bp component, and others to a first distillation column; separating a lower bp fraction containing part of the lower bp component and a higher bp fraction containing part of the higher bp component in the first column; withdrawing a side stream containing at least the carboxylic acid by side cut from the first column; feeding the side stream to a second distillation column; separating a lower bp fraction containing part of the lower bp component and a higher bp fraction containing part of the higher bp component in the second column; and withdrawing a side stream containing the carboxylic acid by side cut from the second column to recover a purified carboxylic acid; and the process further comprises feeding at least one first component (A) selected from the group consisting of an alcohol, corresponding to the carboxylic acid, having “n” carbon atom(s), and an ester of the alcohol with the carboxylic acid to the first column, and if necessary water. Such a process ensures reduction of the concentration of the hydrogen halide in the purified carboxylic acid.

摘要翻译： 制备具有“n + 1”个碳原子的精制羧酸的方法包括进料含有具有“n + 1”个碳原子的羧酸的羧酸流，卤化氢，低沸点（bp）组分，较高沸点 bp组分，其他至第一蒸馏塔; 分离含有部分低级bp组分的较低bp级分和含有第一列中较高bp组分部分的较高bp级分; 通过从第一塔侧面切割来抽出至少含有羧酸的侧流; 将侧流进料到第二蒸馏塔; 分离含有部分低级bp组分的较低bp级分和含有第二列中较高bp成分部分的较高bp级分; 通过从第二塔侧面切断含有羧酸的侧流，以回收纯化的羧酸; 该方法进一步包括将至少一种选自由对应于具有“n”个碳原子的羧酸的醇和醇与羧酸的醇组成的组中的至少一种第一组分加入到 第一列，如果需要的话。 这样的方法确保了精制羧酸中卤化氢浓度的降低。

公开(公告)号：US20090036710A1

公开(公告)日：2009-02-05

申请号：US11922339

申请日：2006-07-11

申请人： Hiroyuki Miura ,  Hidetaka Kojima

发明人： Hiroyuki Miura ,  Hidetaka Kojima

IPC分类号： C07C51/42

CPC分类号： C07C51/44 ,  C07C53/08 ,  C07C53/122

摘要： A process for producing a purified carboxylic acid having “n+1” carbon atoms comprises feeding a carboxylic acid stream containing a carboxylic acid having “n+1” carbon atoms, a hydrogen halide, a lower boiling point (bp) component, a higher bp component, and others to a first distillation column; separating a lower bp fraction containing part of the lower bp component and a higher bp fraction containing part of the higher bp component in the first column; withdrawing a side stream containing at least the carboxylic acid by side cut from the first column; feeding the side stream to a second distillation column; separating a lower bp fraction containing part of the lower bp component and a higher bp fraction containing part of the higher bp component in the second column; and withdrawing a side stream containing the carboxylic acid by side cut from the second column to recover a purified carboxylic acid; and the process further comprises feeding at least one first component (A) selected from the group consisting of an alcohol, corresponding to the carboxylic acid, having “n” carbon atom(s), and an ester of the alcohol with the carboxylic acid to the first column, and if necessary water. Such a process ensures reduction of the concentration of the hydrogen halide in the purified carboxylic acid.

摘要翻译： 制备具有“n + 1”个碳原子的精制羧酸的方法包括进料含有具有“n + 1”个碳原子的羧酸的羧酸流，卤化氢，低沸点（bp）组分，较高沸点 bp组分，其他至第一蒸馏塔; 分离含有部分低级bp组分的较低bp级分和含有第一列中较高bp组分部分的较高bp级分; 通过从第一塔侧面切割来抽出至少含有羧酸的侧流; 将侧流进料到第二蒸馏塔; 分离含有部分低级bp组分的较低bp级分和含有第二列中较高bp成分部分的较高bp级分; 通过从第二塔侧面切断含有羧酸的侧流，以回收纯化的羧酸; 该方法进一步包括将至少一种选自由对应于具有“n”个碳原子的羧酸的醇和醇与羧酸的醇组成的组中的至少一种第一组分加入到 第一列，如果需要的话。 这样的方法确保了精制羧酸中卤化氢浓度的降低。

公开(公告)号：US5391821A

公开(公告)日：1995-02-21

申请号：US231592

申请日：1994-04-20

申请人： Hiroshi Koyama ,  Hidetaka Kojima

发明人： Hiroshi Koyama ,  Hidetaka Kojima

IPC分类号： C07C51/12 ,  C07C45/50

CPC分类号： C07C51/12

摘要： Carboxylic acids are produced in the liquid phase carbonylation reaction from an alcohol or its derivative and carbon monoxide in the presence of a catalyst system containing a rhodium component and an alkyl halide and water, adding an iodide salt to the rhodium/alkyl halide catalyst system so as to maintain the iodine ion concentration in the carbonylation reaction solution at 0.3 mol/l or higher.

摘要翻译： 在含有铑组分和烷基卤化物和水的催化剂体系的存在下，在醇或其衍生物和一氧化碳的液相羰基化反应中产生羧酸，向铑/烷基卤催化剂体系中加入碘化物盐 以使羰基化反应溶液中的碘离子浓度维持在0.3mol / l以上。

公开(公告)号：US4735749A

公开(公告)日：1988-04-05

申请号：US914684

申请日：1986-10-02

申请人： Takaaki Fujiwa ,  Hidetaka Kojima

发明人： Takaaki Fujiwa ,  Hidetaka Kojima

IPC分类号： C07C51/58 ,  A01N43/56 ,  B01J31/00 ,  C07B61/00 ,  C07C51/00 ,  C07C51/12 ,  C07C51/46 ,  C07C51/56 ,  C07C51/573 ,  C07C51/60 ,  C07C53/08 ,  C07C53/12 ,  C07C53/122 ,  C07C67/00 ,  C07D231/38

CPC分类号： C07D231/38 ,  A01N43/56 ,  C07C243/00 ,  C07C255/00 ,  C07C51/56 ,  C07C51/573

摘要： A process is provided for producing an O-acetyl compound by carbonylating an O-methyl compound with carbon monoxide in the presence of a rhodium catalyst and an iodine compound, comprising(i) separating the reaction mixture formed in the carbonylation reaction step into a volatile component and a rhodium-containing catalyst solution,(ii) heat-treating the separated catalyst solution in the presence of a hydrogen-containing gas, and(iii) recirculating the hydrogenated catalyst solution to the carbonylation reaction step. According to this invention, it is possible to select a hydrogen treatment condition most suited for recirculation of a catalyst.

摘要翻译： 提供了通过在铑催化剂和碘化合物的存在下用一氧化碳羰基化O-甲基化合物来制备O-乙酰基化合物的方法，其包括（i）将在羰基化反应步骤中形成的反应混合物分离成挥发性 组分和含铑催化剂溶液，（ii）在含氢气体存在下对分离的催化剂溶液进行热处理，和（iii）将氢化催化剂溶液再循环到羰基化反应步骤。 根据本发明，可以选择最适合于催化剂再循环的氢处理条件。

公开(公告)号：US4625058A

公开(公告)日：1986-11-25

申请号：US710821

申请日：1985-03-12

申请人： Takaaki Fujiwa ,  Hidetaka Kojima

发明人： Takaaki Fujiwa ,  Hidetaka Kojima

IPC分类号： C07C51/54 ,  B01J21/02 ,  B01J27/08 ,  B01J31/00 ,  B01J31/04 ,  B01J31/14 ,  B01J31/28 ,  B01J31/34 ,  C07B61/00 ,  C07C51/00 ,  C07C51/56 ,  C07C53/08 ,  C07C53/12 ,  C07C53/122 ,  C07C67/00 ,  C07C51/12

CPC分类号： C07C51/56

摘要： This invention provides a process for producing an oxy-acetyl compound by carbonylating an oxy-methyl compound with carbon monoxide in the presence of a rhodium catalyst, an iodine compound, and a metallic accelerator, and also in the presence of at least one compound selected from the group consisting of boron compounds, bismuth compounds, and tertiary amide compounds in the reaction system. When at least one of the bismuth or boron compound is present in the reaction system, the carbonylation reaction can proceed without precipitation of any metallic accelerator.

摘要翻译： 本发明提供了一种通过在铑催化剂，碘化合物和金属促进剂存在下，用一氧化碳羰基化氧甲基化合物以及选择至少一种化合物的方法制备氧 - 乙酰化合物的方法 在反应体系中由硼化合物，铋化合物和叔酰胺化合物组成的组。 当反应体系中存在至少一种铋或硼化合物时，羰基化反应可以进行而不会沉淀任何金属促进剂。

公开(公告)号：US4567305A

公开(公告)日：1986-01-28

申请号：US621016

申请日：1984-06-15

申请人： Mitsuo Matsumoto ,  Shinichi Miura ,  Koichi Kikuchi ,  Masuhiko Tamura ,  Hidetaka Kojima ,  Kunio Koga ,  Shigeru Yamashita

发明人： Mitsuo Matsumoto ,  Shinichi Miura ,  Koichi Kikuchi ,  Masuhiko Tamura ,  Hidetaka Kojima ,  Kunio Koga ,  Shigeru Yamashita

IPC分类号： C07C45/50 ,  B01J31/00 ,  B01J31/24 ,  C07B61/00 ,  C07C45/00 ,  C07C45/49 ,  C07C47/19 ,  C07C67/00

CPC分类号： C07C45/49

摘要： Allyl alcohol is hydroformylated with a gaseous mixture of hydrogen and carbon monoxide, in an aromatic hydrocarbon, in the presence of a rhodium complex and a trisubstituted phosphine, to form hydroxybutyraldehydes which are separated from the reaction mixture within an aqueous medium. The carbon monoxide partial pressure, the rate of consumption of carbon monoxide, the rate at which the carbon monoxide is dissolved in the reaction mixture, reaction temperature and the viscosity of the reaction mixture are selected and controlled in an interrelated way to give a high yield of 4-hydroxybutyraldehyde and reduced catalyst consumption.

摘要翻译： 烯丙醇在氢气和一氧化碳的气体混合物中，在芳族烃中，在铑配合物和三取代膦的存在下加氢甲酰化，以形成在水性介质中与反应混合物分离的羟基丁醛。 一氧化碳分压，一氧化碳消耗速率，一氧化碳溶解在反应混合物中的速率，反应温度和反应混合物的粘度以相互关联的方式选择和控制，以产生高产率 的4-羟基丁醛和降低的催化剂消耗。

公开(公告)号：US4118388A

公开(公告)日：1978-10-03

申请号：US823477

申请日：1977-08-10

申请人： Takushi Yokoyama ,  Hidetaka Kojima ,  Masaharu Uragami ,  Kathuyoshi Miwa

发明人： Takushi Yokoyama ,  Hidetaka Kojima ,  Masaharu Uragami ,  Kathuyoshi Miwa

IPC分类号： B01J23/00 ,  B01J23/68 ,  C07B61/00 ,  C07D213/06 ,  C07D213/127 ,  C07D213/16

CPC分类号： C07D213/06 ,  B01J23/683

摘要： A process for producing pyridine which comprises oxidatively dealkylating an alkylpyridine, an alkenylpyridine or a mixture thereof in the gaseous phase with molecular oxygen and steam in the presence of a catalyst comprising active components with a general composition of the formulav.sub.a X.sub.b Ag.sub.c O.sub.wherein a, c, and d respectively represent the atomic proportions of vanadium, silver and oxygen; X represents at least one element selected from the group consisting of chromium, molybdenum and tungsten; b represents the atomic proportion of X; and when a is 1, b is about 0.1 to about 1.5, c is about 0.005 to about 1.0, and d represents the atomic proportion of oxygen, is a value determined by the atomic valences of the individual V, X and Ag elements and is about 2.6 to about 7.5; and separating pyridine from the reaction product.

摘要翻译： 一种制备吡啶的方法，其包括在包含活性组分与通式VAXbAgcO的一般组合物的催化剂存在下，将气态的烷基吡啶，烯基吡啶或其混合物与分子氧和蒸汽进行氧化脱烷基化，其中a，c和 d分别代表钒，银和氧的原子比例; X表示选自铬，钼和钨中的至少一种元素; b表示X的原子比例; 当a为1时，b为约0.1至约1.5，c为约0.005至约1.0，d表示氧的原子比例，是由各V，X和Ag元素的原子价决定的值，为 约2.6至约7.5; 并从反应产物中分离出吡啶。

公开(公告)号：US20090082593A1

公开(公告)日：2009-03-26

申请号：US11992129

申请日：2006-09-26

申请人： Hidetaka Kojima

发明人： Hidetaka Kojima

IPC分类号： C07C51/12

CPC分类号： C07C51/12 ,  C07C53/08

摘要： A process produces acetic acid by continuously carrying out a reaction of methanol with carbon monoxide in the presence of a Group VIII metal catalyst, an iodide salt, methyl iodide, and water in a reactor, continuously withdrawing a reaction mixture from the reactor, introducing the reaction mixture into an evaporation process at a pressure lower than that in the reaction to separate the reaction mixture into low-boiling components and high-boiling components containing the Group VIII metal and the iodide salt, and recycling the separated high-boiling components containing the Group VIII metal and the iodide salt to the reactor, in which the separated high-boiling components are brought into contact with hydrogen at temperatures of 80° C. or higher for 6 seconds or longer before the high-boiling components reaching the reactor, which hydrogen is introduced in an amount of 0.1 time by mole or more that of the Group VIII metal. According to the process, industrially, acetic acid is efficiently produced with high productivity, because the activity of a catalyst in a reactor may be increased without increasing a hydrogen partial pressure in the reactor more than necessary, and a shift reaction may be suppressed to thereby reduce by-products.

摘要翻译： 一种方法是在第VIII族金属催化剂，碘化物盐，甲基碘和水的存在下，在反应器中连续进行甲醇与一氧化碳的反应，连续地从反应器中取出反应混合物， 反应混合物进入蒸发过程，其压力低于反应中的压力，将反应混合物分离成低沸点组分和含有VIII族金属和碘化物盐的高沸点组分，并将分离的高沸点组分 VIII族金属和碘化物盐，其中分离的高沸点组分在高沸点组分到达反应器之前在80℃或更高的温度下与氢接触6秒或更长，其中 氢的导入量为第Ⅷ族金属0.1摩尔％以上。 根据该方法，在工业上，由于反应器中的催化剂的活性可以增加而不增加反应器中的氢分压，因此可以高效率地生产乙酸，因此可以抑制转化反应，从而 减少副产品。