公开(公告)号：US4501738A

公开(公告)日：1985-02-26

申请号：US620923

申请日：1984-06-15

申请人： Hideyuki Yamato ,  Yuji Maeda ,  Fumisato Yoshino ,  Kyoya Takahata ,  Masanori Ikuzawa ,  Tadaaki Kato ,  Chikao Yoshikumi

发明人： Hideyuki Yamato ,  Yuji Maeda ,  Fumisato Yoshino ,  Kyoya Takahata ,  Masanori Ikuzawa ,  Tadaaki Kato ,  Chikao Yoshikumi

IPC分类号： A61K31/59

CPC分类号： A61K31/59

摘要： Disclosed is a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of pains and pyrexia, hypertension, hypotension, hyperlipemia, inflammatory diseases or diseases due to the functional accentuation of thrombocytes of a compound of 24,25-dihydroxycholecalciferol and a pharmaceutical acceptable carrier or diluent therefor.

摘要翻译： 公开了一种剂量单位形式的药物组合物，其包含有效治疗疼痛和发热，高血压，低血压，高脂血症，炎性疾病或由于二羟基胆钙化甾醇化合物的血小板功能强化引起的疾病的剂量 药用载体或稀释剂。

公开(公告)号：US4534975A

公开(公告)日：1985-08-13

申请号：US656760

申请日：1984-10-01

申请人： Hideyuki Yamato ,  Yuji Maeda ,  Fumisato Yoshino ,  Kyoya Takahata ,  Masanori Ikuzawa ,  Tadaaki Kato ,  Chikao Yoshikumi

发明人： Hideyuki Yamato ,  Yuji Maeda ,  Fumisato Yoshino ,  Kyoya Takahata ,  Masanori Ikuzawa ,  Tadaaki Kato ,  Chikao Yoshikumi

IPC分类号： A61K31/59

CPC分类号： A61K31/59

摘要： Disclosed is a pharmaceutical composition in dosage unit form which comprises a dosage effective for the treatment of pains and pyrexia, hypertension, hypotension, hyperlipemia, inflammatory diseases or diseases due to the functional accentuation of thrombocytes of a compound of 24,25-dihydroxycholecalciferol and a pharmaceutical acceptable carrier or diluent therefor.

摘要翻译： 公开了一种剂量单位形式的药物组合物，其包含有效治疗疼痛和发热，高血压，低血压，高脂血症，炎性疾病或由于二羟基胆钙化甾醇化合物的血小板功能强化引起的疾病的剂量 药用载体或稀释剂。

公开(公告)号：US5001118A

公开(公告)日：1991-03-19

申请号：US131399

申请日：1987-12-10

申请人： Yuji Maeda ,  Hideyuki Yamato ,  Toru Hirai ,  Masanori Ikuzawa ,  Mikio Matsuki ,  Masanori Togawa ,  Eiji Inoguchi ,  Sinji Nakajima ,  Tadaaki Kato ,  Chikao Yoshikumi

发明人： Yuji Maeda ,  Hideyuki Yamato ,  Toru Hirai ,  Masanori Ikuzawa ,  Mikio Matsuki ,  Masanori Togawa ,  Eiji Inoguchi ,  Sinji Nakajima ,  Tadaaki Kato ,  Chikao Yoshikumi

IPC分类号： A61K31/59

CPC分类号： A61K31/59

摘要： Disclosed herein is a method for preventing senescence and increasing bone mass namely, bone volume and bone strength which method comprises administering 24,25-dihydroxy cholecalciferol in a pharmaceutically effective amount, and also use of 24,25-dihydroxy cholecalciferol for preparing anti-senescent compositions and compositions for increasing bone mass.

公开(公告)号：US4820689A

公开(公告)日：1989-04-11

申请号：US898900

申请日：1986-08-22

申请人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

发明人： Masanori Ikuzawa ,  Yoshiharu Oguchi ,  Kenichi Matsunaga ,  Noriyuki Toyoda ,  Takao Furusho ,  Takayoshi Fujii ,  Chikao Yoshikumi

IPC分类号： A61K38/00 ,  C07K14/375 ,  A61K37/02 ,  A61K35/70

CPC分类号： C07K14/375 ,  A61K38/00 ,  Y10S435/911

摘要： Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretic activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

摘要翻译： 本文公开了具有抗风湿活性，抗血栓活性，止痛活性，解热活性，抗高血脂活性和抗炎活性以及降低血糖水平的活性，提高冠状动脉血流量，提高变形能力的药物组合物 红细胞，降低血压，改善蛋白尿和蛋白血症，并以剂量​​单位形式调节哺乳动物中前列腺素的产生或代谢，其包括有效产生分子量为5000至300000的糖蛋白的活性的剂量，其通过超速离心 方法和约18〜38重量％的蛋白质，通过培养属于科氏菌属的嗜碱性真菌属真菌属物种，用热水或碱性水溶液提取如此增殖的菌丝体或果实体并除去分子量低的分子量物质 从不到5000 e提取。

公开(公告)号：US4673669A

公开(公告)日：1987-06-16

申请号：US786851

申请日：1985-10-11

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R donotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明公开了含有氨基苯甲酸衍生物作为活性成分的药物组合物，其由以下通式表示：其中，R 1表示选自由1（α）或1（α） β）位置，或其药学上可接受的盐。

公开(公告)号：US4657895A

公开(公告)日：1987-04-14

申请号：US772477

申请日：1985-09-04

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-L-rhamonoside or a pharmaceutically acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-L-鼠李糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4569842A

公开(公告)日：1986-02-11

申请号：US352858

申请日：1982-02-26

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R denotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US4957906A

公开(公告)日：1990-09-18

申请号：US163204

申请日：1988-02-26

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R donotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US4757054A

公开(公告)日：1988-07-12

申请号：US4308

申请日：1987-01-07

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70 ,  C08B37/00

CPC分类号： C07H15/203

摘要： Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.

摘要翻译： 公开了含有对氨基苯甲酸-N-D-木糖苷或其药学上可接受的盐作为活性成分的药物组合物。

公开(公告)号：US4440757A

公开(公告)日：1984-04-03

申请号：US174543

申请日：1980-08-01

申请人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

发明人： Chikao Yoshikumi ,  Yoshio Ohmura ,  Fumio Hirose ,  Masanori Ikuzawa ,  Kenichi Matsunaga ,  Takayoshi Fujii ,  Minoru Ohhara ,  Takao Ando

IPC分类号： C07H15/203 ,  A61K31/70

CPC分类号： C07H15/203

摘要： A pharmaceutical composition for regulating prostagrandins, which comprises (a) a derivative of aminobenzoic acid, represented by the following general formula: ##STR1## wherein R.sup.1 denotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha)-or 1(beta) position from arabinose, xylose, rhamnose, glucose, galactose, mannose and fructose, and R.sup.2 is a hydrogen atom, an alkyl group of one to four carbon atoms or a pharmaceutically acceptable metal, and (b) a pharmaceutically acceptable carrier or diluent of (a) is disclosed.

摘要翻译： 一种用于调节前列腺素的药物组合物，其包含（a）由以下通式表示的氨基苯甲酸衍生物：其中R 1表示选自由1（α）除去OH形成的残基， ） - 或来自阿拉伯糖，木糖，鼠李糖，葡萄糖，半乳糖，甘露糖和果糖的1（β）位置，并且R 2是氢原子，1-4个碳原子的烷基或药学上可接受的金属，和（b） 公开了（a）的药学上可接受的载体或稀释剂。