公开(公告)号：US07519151B1

公开(公告)日：2009-04-14

申请号：US11904458

申请日：2007-09-26

申请人： Himanshu P. Shukla ,  Jonathan Maltz

发明人： Himanshu P. Shukla ,  Jonathan Maltz

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61B6/025 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/585 ,  A61N5/1038 ,  A61N5/1065 ,  A61N2005/1061

摘要： A system includes movement of a treatment delivering x-ray source to a treatment position, creation of projection images of a target using an imaging x-ray source while the treatment delivering x-ray source is disposed at the treatment position, and performance of digital tomosynthesis on the projection images while the treatment delivering x-ray source is disposed at the treatment position to generate a cross-sectional image of the target. A characteristic of an x-ray beam to be delivered by the treatment delivering x-ray source may be automatically modified based on the cross-sectional image. In some aspects, the imaging x-ray source translates in a plane normal to a beam axis of the treatment delivering x-ray source at the treatment position, and pivots about an axis passing through the imaging x-ray source during creation of projection images. Creation of the projection images may alternatively include emission of a respective x-ray beam from each of a plurality of sources of the imaging x-ray source, wherein the imaging x-ray source is stationary with respect to the treatment delivering x-ray source during creation of the projection images.

摘要翻译： 一种系统包括将x射线源传送到治疗位置的处理运动，使用成像x射线源创建靶的投影图像，同时将x射线源处理设置在治疗位置，以及数字 投影图像上的层析合成，而将X射线源的处理设置在处理位置以产生目标的横截面图像。 可以基于横截面图像自动修改通过递送x射线源的处理来传送的x射线束的特性。 在一些方面，成像x射线源平移在与治疗位置处输送x射线源的处理的束轴垂直的平面中，并且在创建投影图像期间围绕穿过成像x射线源的轴线枢转 。 替代地，投影图像的创建可以包括从成像x射线源的多个源中的每一个源发射相应的X射线束，其中成像x射线源相对于递送x射线源的治疗是静止的 在创建投影图像期间。

公开(公告)号：US20090080603A1

公开(公告)日：2009-03-26

申请号：US11904458

申请日：2007-09-26

申请人： Himanshu P. Shukla ,  Jonathan Maltz

发明人： Himanshu P. Shukla ,  Jonathan Maltz

IPC分类号： A61B6/02

CPC分类号： A61N5/1049 ,  A61B6/025 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/585 ,  A61N5/1038 ,  A61N5/1065 ,  A61N2005/1061

摘要： A system includes movement of a treatment delivering x-ray source to a treatment position, creation of projection images of a target using an imaging x-ray source while the treatment delivering x-ray source is disposed at the treatment position, and performance of digital tomosynthesis on the projection images while the treatment delivering x-ray source is disposed at the treatment position to generate a cross-sectional image of the target. A characteristic of an x-ray beam to be delivered by the treatment delivering x-ray source may be automatically modified based on the cross-sectional image. In some aspects, the imaging x-ray source translates in a plane normal to a beam axis of the treatment delivering x-ray source at the treatment position, and pivots about an axis passing through the imaging x-ray source during creation of projection images. Creation of the projection images may alternatively include emission of a respective x-ray beam from each of a plurality of sources of the imaging x-ray source, wherein the imaging x-ray source is stationary with respect to the treatment delivering x-ray source during creation of the projection images.

摘要翻译： 一种系统包括将x射线源传送到治疗位置的处理运动，使用成像x射线源创建靶的投影图像，同时将x射线源处理设置在治疗位置，以及数字 投影图像上的层析合成，而将X射线源的处理设置在处理位置以产生目标的横截面图像。 可以基于横截面图像自动修改通过递送x射线源的处理来传送的x射线束的特性。 在一些方面，成像x射线源平移在与治疗位置处输送x射线源的处理的束轴垂直的平面中，并且在创建投影图像期间围绕穿过成像x射线源的轴线枢转 。 替代地，投影图像的创建可以包括从成像x射线源的多个源中的每一个源发射相应的X射线束，其中成像x射线源相对于递送x射线源的治疗是静止的 在创建投影图像期间。

公开(公告)号：US20120197058A1

公开(公告)日：2012-08-02

申请号：US13016768

申请日：2011-01-28

申请人： Himanshu P. Shukla ,  Walter A. Aguilar

发明人： Himanshu P. Shukla ,  Walter A. Aguilar

IPC分类号： A61N5/00

CPC分类号： A61N5/1047 ,  A61N5/103

摘要： Some aspects include a system, method, and computer-readeable medium to divide a representation of a target volume into an array of sub-volumes; define a high dose volume to which a high dose of radiation is to be delivered; define a plurality of sampling volumes; direct an estimated dose of radiation to each sub-volume; determine whether the dose of radiation delivered to each high dose volume is at least a minimum threshold dose, and that the radiation delivered to the plurality of sampling volumes for each of the sub-volumes is at least a minimum difference less than the radiation delivered to the high dose volume; adjust the estimated dose of radiation directed to each sub-volume; and develop a radiation treatment plan, including the adjusted dose, to invoke a biological effect of spatially separated radiation.

摘要翻译： 一些方面包括将目标卷的表示划分为子卷阵列的系统，方法和计算机可重用介质; 定义高剂量的体积，高剂量的辐射将被输送到其上; 定义多个采样体积; 将辐射的估计剂量指示给每个子体积; 确定输送到每个高剂量体积的辐射剂量是否至少是最小阈值剂量，并且递送到每个子体积的多个采样体积的辐射是至少最小差异小于递送到 高剂量体积; 调整针对每个子体积的辐射的估计剂量; 并制定辐射治疗计划，包括调整剂量，以调用空间分离的辐射的生物学效应。

公开(公告)号：US20110305380A1

公开(公告)日：2011-12-15

申请号：US12797093

申请日：2010-06-09

申请人： Supratik Bose ,  Himanshu P. Shukla

发明人： Supratik Bose ,  Himanshu P. Shukla

IPC分类号： G06K9/00

CPC分类号： A61N5/1075 ,  A61N2005/1076

摘要： Some embodiments include obtaining a projection image of a plurality of fiducials associated with a coordinate system irradiated by a radiotherapy radiation source at a plurality of discrete locations on a trajectory path model, determination of a projection matrix from projection images of the fiducials irradiated by the radiotherapy radiation source at each of the discrete locations, determination of the actual coordinate of the radiotherapy radiation source in the coordinate system associated with the fiducials at the plurality of discrete locations based on the determined projection matrices, and correlating the trajectory path model of the radiotherapy radiation source to the determined actual position of the radiotherapy radiation source at the discrete locations.

摘要翻译： 一些实施例包括在轨迹路径模型上的多个离散位置处获得与由放射线辐射源照射的坐标系相关联的多个基准的投影图像，从由放射线照射的基准的投影图像确定投影矩阵 在每个离散位置处的辐射源，基于所确定的投影矩阵确定与所述多个离散位置处的基准相关联的坐标系中的放射治疗辐射源的实际坐标，以及将放射线辐射的轨迹路径模型 来源于放射治疗辐射源在离散位置处的确定的实际位置。

公开(公告)号：US07668292B1

公开(公告)日：2010-02-23

申请号：US12198645

申请日：2008-08-26

申请人： Supratik Bose ,  Himanshu P. Shukla

发明人： Supratik Bose ,  Himanshu P. Shukla

IPC分类号： A61N5/10 ,  G21K5/08

CPC分类号： A61N5/1049 ,  A61N5/103 ,  G06F19/00 ,  G06F19/3481

摘要： In some embodiments, a method includes receiving, in a processor, information indicative of (i) a treatment plan defining planned treatment beams, (ii) a patient volume relative to a reference, (iii) ideal intersections of the planned treatment beams with the patient volume at the time the patient is to be treated, (iv) any constraints that prevent achievement of the recommended repositioning using only the patient support, (v) an allowable change to a gantry position from a planned value and an allowable change to a collimator position from a planned value; defining, in the processor, a plurality of alternatives based at least in part on the information indicative of any constraints of the patient support and the information indicative of allowable movement of the gantry and collimator, each alternative defining a modified patient support position and modified beams, each modified beam being based at least in part on a respective one of the planned treatment beams, the change to the position of the gantry for the respective planned treatment beam and the change to the position of the collimator for the respective planned treatment beam; determining, in the processor, for each modified beam of each alternative, an intersection of the patient volume and the modified beam, with the patient volume positioned on the patient support and the patient support having the modified patient support position defined by the alternative; and defining, in the processor, for each alternative, a measure of difference between the ideal intersections and the intersections for the modified beams of the alternative.

摘要翻译： 在一些实施例中，一种方法包括在处理器中接收指示（i）定义计划治疗束的治疗计划，（ii）相对于参考的患者体积的信息的信息，（iii）计划治疗束与 病人治疗时的患者体积，（iv）仅使用患者支持阻止实现推荐重新定位的任何限制，（v）从计划值允许的台架位置变化和允许的变化到 准直器位置从计划值; 在处理器中至少部分地基于指示患者支持的任何限制的信息和指示台架和准直器的允许移动的信息在处理器中定义多个替代方案，每个替代方案限定修改的患者支撑位置和修改的束 每个修改的梁至少部分地基于计划的处理梁中的相应一个，对于相应的计划处理梁的台架的位置的改变以及对于各个计划的处理梁的准直器的位置的改变; 在所述处理器中，针对每个替代方案的每个修改的波束，确定所述患者体积和所述修改的束的交叉点，其中所述患者体积位于所述患者支架上，并且所述患者支架具有由所述替代方案限定的所述修改的患者支撑位置; 并且在处理器中针对每个替代方案来定义理想交叉点与替代方案的修改梁的交点之间的差异度量。

公开(公告)号：US07746974B2

公开(公告)日：2010-06-29

申请号：US11540043

申请日：2006-09-29

申请人： Himanshu P. Shukla

发明人： Himanshu P. Shukla

IPC分类号： A61B6/00

CPC分类号： G01N23/046 ,  A61B6/032 ,  A61B6/4028 ,  G01N2223/419 ,  G01N2223/612

摘要： A system includes emission of first electrons toward a first focal spot using an X-ray tube located at a first position, emission of first radiation from the first focal spot toward an object, acquisition of a first projection of the object based on the emitted first radiation using a computed tomography radiation detector, emission of second electrons toward a second focal spot using the X-ray tube located at the first position, emission of second radiation from the second focal spot toward the object, acquisition of a second projection of the object based on the emitted second radiation using the computed tomography radiation detector, and generation of an image of the object based on the first projection and the second projection.

摘要翻译： 一种系统包括使用位于第一位置的X射线管朝向第一焦点发射第一电子，从第一焦点朝向物体发射第一辐射，基于发射的第一电子发射第一投影物体 使用计算机断层摄影放射线检测器的辐射，使用位于第一位置的X射线管向第二焦点发射第二电子，从第二焦斑向物体发射第二辐射，获取物体的第二投影 基于使用所述计算机断层摄影放射线检测器发射的第二辐射，以及基于所述第一投影和所述第二投影来生成所述物体的图像。

公开(公告)号：US20100061515A1

公开(公告)日：2010-03-11

申请号：US12205608

申请日：2008-09-05

申请人： Himanshu P. Shukla

发明人： Himanshu P. Shukla

IPC分类号： H05G1/10 ,  H05G1/64

CPC分类号： A61N5/1049 ,  A61N5/1037 ,  A61N2005/1061

摘要： An apparatus, method, system, and means to detect motion of a subject by direct imaging on a treatment plane during a radiotherapy treatment, the method includes delivering a radiotherapy treatment beam to a volume of interest of the subject during a treatment time, acquiring image data during the treatment time associated with the delivery of the radiotherapy treatment beam by a direct imaging of a projection of the treatment volume of interest, providing a real-time display of the acquired image data, determining the occurrence of a motion in the volume of interest during the treatment time, determining the motion exceeds a pre-determined threshold, and outputting an indication the determined motion exceeds the pre-determined threshold during the treatment time.

摘要翻译： 一种在放射治疗期间通过在治疗平面上直接成像来检测受试者的运动的装置，方法，系统和装置，所述方法包括在治疗时间期间将放射疗法治疗束传送到受试者的感兴趣体积，获取图像 通过对感兴趣的治疗体积的投影进行直接成像，提供与放射疗法治疗束的输送相关联的治疗期间的数据，提供所获取的图像数据的实时显示，确定所获取的图像数据的运动的发生 在治疗时间期间的兴趣，确定运动超过预定阈值，并且在治疗时间期间输出所确定的运动超过预定阈值的指示。

公开(公告)号：US20100054409A1

公开(公告)日：2010-03-04

申请号：US12198645

申请日：2008-08-26

申请人： Supratik Bose ,  Himanshu P. Shukla

发明人： Supratik Bose ,  Himanshu P. Shukla

IPC分类号： A61N5/10

CPC分类号： A61N5/1049 ,  A61N5/103 ,  G06F19/00 ,  G06F19/3481

摘要： In some embodiments, a method includes receiving, in a processor, information indicative of (i) a treatment plan defining planned treatment beams, (ii) a patient volume relative to a reference, (iii) ideal intersections of the planned treatment beams with the patient volume at the time the patient is to be treated, (iv) any constraints that prevent achievement of the recommended repositioning using only the patient support, (v) an allowable change to a gantry position from a planned value and an allowable change to a collimator position from a planned value; defining, in the processor, a plurality of alternatives based at least in part on the information indicative of any constraints of the patient support and the information indicative of allowable movement of the gantry and collimator, each alternative defining a modified patient support position and modified beams, each modified beam being based at least in part on a respective one of the planned treatment beams, the change to the position of the gantry for the respective planned treatment beam and the change to the position of the collimator for the respective planned treatment beam; determining, in the processor, for each modified beam of each alternative, an intersection of the patient volume and the modified beam, with the patient volume positioned on the patient support and the patient support having the modified patient support position defined by the alternative; and defining, in the processor, for each alternative, a measure of difference between the ideal intersections and the intersections for the modified beams of the alternative.

摘要翻译： 在一些实施例中，一种方法包括在处理器中接收指示（i）定义计划治疗束的治疗计划，（ii）相对于参考的患者体积的信息的信息，（iii）计划治疗束与 病人治疗时的患者体积，（iv）仅使用患者支持阻止实现推荐重新定位的任何限制，（v）从计划值允许的台架位置变化和允许的变化到 准直器位置从计划值; 在处理器中至少部分地基于指示患者支持的任何限制的信息和指示台架和准直器的允许移动的信息在处理器中定义多个替代方案，每个替代方案限定修改的患者支撑位置和修改的束 每个修改的梁至少部分地基于计划的处理梁中的相应一个，对于相应的计划处理梁的台架的位置的改变以及对于各个计划的处理梁的准直器的位置的改变; 在所述处理器中，针对每个替代方案的每个修改的波束，确定所述患者体积和所述修改的束的交叉点，其中所述患者体积位于所述患者支架上，并且所述患者支架具有由所述替代方案限定的所述修改的患者支撑位置; 并且在处理器中针对每个替代方案来定义理想交叉点与替代方案的修改梁的交点之间的差异度量。

公开(公告)号：US07636461B2

公开(公告)日：2009-12-22

申请号：US10597566

申请日：2005-01-24

申请人： Lothar Spies ,  Celine Saint Olive ,  Michael Kaus ,  Vladimir Pekar ,  Himanshu P. Shukla

发明人： Lothar Spies ,  Celine Saint Olive ,  Michael Kaus ,  Vladimir Pekar ,  Himanshu P. Shukla

IPC分类号： G06K9/00

CPC分类号： G06T11/008 ,  G06T2211/424

摘要： A reconstruction processor (34) reconstructs acquired projection data (S) into an uncorrected reconstructed image (T). A classifying algorithm (66) classifies pixels of the uncorrected reconstructed image (T) at least into metal, bone, tissue, and air pixel classes. A clustering algorithm (60) iteratively assigns pixels to best fit classes. A pixel replacement algorithm (70) replaces metal class pixels of the uncorrected reconstructed image (T) with pixel values of the bone density class to generate a metal free image. A morphological algorithm (80) applies prior knowledge of the subject's anatomy to the metal free image to correct the shapes of the class regions to generate a model tomogram image. A forward projector (88) forward projects the model tomogram image to generate model projection data (Smodel). A corrupted rays identifying algorithm (100) identifies the rays in the original projection data (S) which lie through the regions containing metal objects. A corrupted rays replacement algorithm (102) replaces the corrupted regions with corresponding regions of the model projection data to generate corrected projection data (S′). The reconstruction processor (34) reconstructs the corrected projection data (S) into a corrected reconstructed 3D image (T′).

摘要翻译： 重建处理器（34）将所获取的投影数据（S）重建成未校正的重建图像（T）。 分类算法（66）至少将未校正的重建图像（T）的像素分类为金属，骨骼，组织和空气像素类。 聚类算法（60）迭代地将像素分配给最佳拟合类。 像素替换算法（70）用未被校正的重建图像（T）的金属类像素替换骨密度类别的像素值，以产生无金属图像。 形态学算法（80）将受试者解剖学的先验知识应用于无金属图像，以校正类别区域的形状以产生模型断层图像。 向前投影仪（88）向前投影模型断层图像以产生模型投影数据（Smodel）。 损坏的光线识别算法（100）识别穿过包含金属物体的区域的原始投影数据（S）中的光线。 损坏的光线替换算法（102）将损坏的区域替换为模型投影数据的相应区域，以产生校正投影数据（S'）。 重构处理器（34）将经校正的投影数据（S）重建为经校正的重建3D图像（T'）。

公开(公告)号：US20080253635A1

公开(公告)日：2008-10-16

申请号：US10597566

申请日：2005-01-24

申请人： Lothar Spies ,  Celine Saint Olive ,  Michael Kaus ,  Vladimir Pekar ,  Himanshu P. Shukla

发明人： Lothar Spies ,  Celine Saint Olive ,  Michael Kaus ,  Vladimir Pekar ,  Himanshu P. Shukla

IPC分类号： G06T11/00

CPC分类号： G06T11/008 ,  G06T2211/424

摘要： A reconstruction processor (34) reconstructs acquired projection data (S) into an uncorrected reconstructed image (T). A classifying algorithm (66) classifies pixels of the uncorrected reconstructed image (T) at least into metal, bone, tissue, and air pixel classes. A clustering algorithm (60) iteratively assigns pixels to best fit classes. A pixel replacement algorithm (70) replaces metal class pixels of the uncorrected reconstructed image (T) with pixel values of the bone density class to generate a metal free image. A morphological algorithm (80) applies prior knowledge of the subject's anatomy to the metal free image to correct the shapes of the class regions to generate a model tomogram image. A forward projector (88) forward projects the model tomogram image to generate model projection data (Smodel). A corrupted rays identifying algorithm (100) identifies the rays in the original projection data (S) which lie through the regions containing metal objects. A corrupted rays replacement algorithm (102) replaces the corrupted regions with corresponding regions of the model projection data to generate corrected projection data (S). The reconstruction processor (34) reconstructs the corrected projection data (S) into a corrected reconstructed 3D image (T′).

摘要翻译： 重建处理器（34）将所获取的投影数据（S）重建成未校正的重建图像（T）。 分类算法（66）至少将未校正的重建图像（T）的像素分类为金属，骨骼，组织和空气像素类。 聚类算法（60）迭代地将像素分配给最佳拟合类。 像素替换算法（70）用未被校正的重建图像（T）的金属类像素替换骨密度类别的像素值，以产生无金属图像。 形态学算法（80）将受试者解剖学的先验知识应用于无金属图像，以校正类别区域的形状以产生模型断层图像。 前向投影仪（88）向前投影模型断层图像以产生模型投影数据（S 模型）。 损坏的光线识别算法（100）识别穿过包含金属物体的区域的原始投影数据（S）中的光线。 损坏的光线替换算法（102）将损坏的区域替换为模型投影数据的相应区域，以产生校正的投影数据（S）。 重构处理器（34）将经校正的投影数据（S）重建为经校正的重建3D图像（T'）。