Inhibitors
    1.
    发明申请
    Inhibitors 审中-公开
    抑制剂

    公开(公告)号:US20070249915A1

    公开(公告)日:2007-10-25

    申请号:US10574469

    申请日:2004-09-30

    IPC分类号: A61B5/00

    CPC分类号: C12Q1/6883 C12Q2600/158

    摘要: The present invention provides a skin test method for predicting the formation of spots in the skin. This method judges skin to be susceptible to the formation of spots in the case expression in the epidermis of MCP-2 gene, a polynucleotide capable of hybridizing under highly stringent conditions to mouse AK012157 gene, human FLJ21763 gene or rat S74257 gene, or Mcp9, Mcp10, Isg15, Usp18, Oas12, Gbp2, Gtpi, Ifi47, Igtp, Tgtp, Sprr2A, Krt2-6b, Cdk5rap2, Mef2C, Gsta4, Osf2, Tnc, Igfbp6, Ppicap or Mm. 74656 gene, is increased as compared with normal expression in the epidermis.

    摘要翻译: 本发明提供一种用于预测皮肤斑点形成的皮肤试验方法。 该方法可以判断皮肤易于在MCP-2基因的表皮中表达的斑点形成,该基因是能够在高度严格条件下与小鼠AK012157基因,人FLJ21763基因或大鼠S74257基因或Mcp9基因杂交的多核苷酸, Mcp10,Isg15,Usp18,Oas12,Gbp2,Gtpi,Ifi47,Igtp,Tgtp,Sprr2A,Krt2-6b,Cdk5rap2,Mef2C,Gsta4,Osf2,Tnc,Igfbp6,Ppicap或Mm。 74656基因与表皮正常表达相比增加。

    Method of predicting spot formation on the skin using spot site-accelerating genes as an indicator thereof and method of screening inhibitors of spot formation on the skin
    2.
    发明授权
    Method of predicting spot formation on the skin using spot site-accelerating genes as an indicator thereof and method of screening inhibitors of spot formation on the skin 失效
    使用斑点位点加速基因作为指标预测皮肤上的斑点形成的方法和筛选皮肤上斑点形成抑制剂的方法

    公开(公告)号:US08142761B2

    公开(公告)日:2012-03-27

    申请号:US12226656

    申请日:2007-04-24

    IPC分类号: A61K49/00

    摘要: The present invention provides a skin test method for predicting the formation of spots in the skin. This method is characterized by judging skin to be susceptible to spot formation in the case expression of genes consisting of MLSTD1, MOGAT1, FADS2, FADS1, HSD3B1, ELOVL3, BG1, PECR, FABP7, FA2H, HAO2, ALOX15B, PDE6A, LZTS1, SEC14L4, BAMBI, CIDEA, TERE1, GAL, THRSP, INSIG1 or CUTL2 in the epidermis is accelerated, or the expression of genes consisting of RBBP6, MSMB, WIF1, ANKRD12, FLG, SYNE2, SCEL, NKTR or AMBP in the epidermis is decreased as compared with normal expression in the epidermis.

    摘要翻译: 本发明提供一种用于预测皮肤斑点形成的皮肤试验方法。 该方法的特征在于在由MLSTD1,MOGAT1,FADS2,FADS1,HSD3B1,ELOVL3,BG1,PECR,FABP7,FA2H,HAO2,ALOX15B,PDE6A,LZTS1,SEC14L4组成的基因的病例表达中判断皮肤易发生斑点形成 表皮中的BAMBI,CIDEA,TERE1,GAL,THRSP,INSIG1或CUTL2被加速,或者表皮中由RBBP6,MSMB,WIF1,ANKRD12,FLG,SYNE2,SCEL,NKTR或AMBP组成的基因的表达减少为 与正常表皮相比较。

    Method of Predicting Spot Formation on the Skin Using Spot Site-Accelerating Genes as an Indicator Thereof and Method of Screening Inhibitors of Spot Formation on the Skin
    3.
    发明申请
    Method of Predicting Spot Formation on the Skin Using Spot Site-Accelerating Genes as an Indicator Thereof and Method of Screening Inhibitors of Spot Formation on the Skin 失效
    使用现场加速基因作为指标预测皮肤斑点形成的方法和筛选皮肤上斑点形成抑制剂的方法

    公开(公告)号:US20090123401A1

    公开(公告)日:2009-05-14

    申请号:US12226656

    申请日:2007-04-24

    IPC分类号: C12Q1/68 A61K45/00 A61Q19/02

    摘要: The present invention provides a skin test method for predicting the formation of spots in the skin. This method is characterized by judging skin to be susceptible to spot formation in the case expression of genes consisting of MLSTD1, MOGAT1, FADS2, FADS1, HSD3B1, ELOVL3, BG1, PECR, FABP7, FA2H, HAO2, ALOX15B, PDE6A, LZTS1, SEC14L4, BAMBI, CIDEA, TERE1, GAL, THRSP, INSIG1 or CUTL2 in the epidermis is accelerated, or the expression of genes consisting of RBBP6, MSMB, WIF1, ANKRD12, FLG, SYNE2, SCEL, NKTR or AMBP in the epidermis is decreased as compared with normal expression in the epidermis.

    摘要翻译: 本发明提供一种用于预测皮肤斑点形成的皮肤试验方法。 该方法的特征在于在由MLSTD1,MOGAT1,FADS2,FADS1,HSD3B1,ELOVL3,BG1,PECR,FABP7,FA2H,HAO2,ALOX15B,PDE6A,LZTS1,SEC14L4组成的基因的病例表达中判断皮肤易发生斑点形成 表皮中的BAMBI,CIDEA,TERE1,GAL,THRSP,INSIG1或CUTL2被加速,或者表皮中由RBBP6,MSMB,WIF1,ANKRD12,FLG,SYNE2,SCEL,NKTR或AMBP组成的基因的表达减少为 与正常表皮相比较。

    Tire
    5.
    发明授权
    Tire 有权

    公开(公告)号:US09593231B2

    公开(公告)日:2017-03-14

    申请号:US10526466

    申请日:2003-09-01

    摘要: The present invention relates to a tire having as a member, a rubber composition comprising (a) 100 mass parts of a rubber component comprising at least one selected from a natural rubber and a diene base synthetic rubber, (b) silica having a nitrogen-absorbing specific surface area (N2SA) of 180 to 270 m2/g and 0.1 to 10.0 mass parts of (c) a partial ester compound of maleic anhydride and a (poly)oxypropylene derivative described above. The tire further comprises as a tread rubber, a rubber composition comprising (A) a rubber component comprising a conjugate diene base rubber, (B) a filler comprising 10 mass % or more of a white filler based on the whole fillers and (C) a partial ester compound of maleic anhydride and a (poly)oxypropylene derivative. This tire has good abrasion resistance, enhanced low heat build-up property, improved processability, excellent driving stability, good physical properties and excellent wet gripping property.

    摘要翻译: 本发明涉及一种具有橡胶组合物的橡胶组合物,该橡胶组合物包含(a)100质量份包含选自天然橡胶和二烯基合成橡胶中的至少一种的橡胶组分,(b)具有氮 - 吸收比表面积(N 2 SA)为180〜270m 2 / g,和0.1〜10.0质量份(c)马来酸酐和(聚)氧丙烯衍生物的偏酯化合物。 轮胎还包括作为胎面橡胶的橡胶组合物,其包含(A)包含共轭二烯基橡胶的橡胶组分,(B)基于整个填料包含10质量%以上的白色填料的填料和(C) 马来酸酐和(聚)氧丙烯衍生物的偏酯化合物。 该轮胎具有良好的耐磨性,增强的低发热性,改善的加工性,优良的驱动稳定性,良好的物理性能和优良的湿抓地性。

    Video encoding device, video encoding method, and video encoding program
    6.
    发明授权
    Video encoding device, video encoding method, and video encoding program 有权
    视频编码设备,视频编码方式和视频编码程序

    公开(公告)号:US09407924B2

    公开(公告)日:2016-08-02

    申请号:US13394061

    申请日:2010-08-09

    摘要: A video encoding device includes a re-encoding picture type judgment unit which judges whether a picture is to be taken as a reference picture or not in a subsequent re-encoding process. A prediction error generation unit generates a prediction error signal so that only a picture to be a reference picture is formed when an encoded picture is formed. The video encoding device includes a quantization control unit for, when the re-encoding picture type judgment unit judges that the picture is to be taken as a reference picture in the subsequent re-encoding process, controlling so that a quantization step for quantization by a quantization unit is smaller than a case where the picture is judged to be taken as a non-reference picture.

    摘要翻译: 视频编码装置包括重新编码图像类型判断单元,其在随后的重新编码处理中判断图像是否被作为参考图像。 预测误差生成单元生成预测误差信号,使得仅在形成编码图像时形成作为参考图像的图像。 该视频编码装置包括量化控制单元,用于当重新编码图像类型判断单元在随后的重新编码处理中判断为要作为参考图像的图像时,控制使得用于量化的量化步长由 量化单位小于将图像判定为非参考图像的情况。

    Video image encoding and decoding device using adaptive pseudo random noise injection during planar mode filtering
    7.
    发明授权
    Video image encoding and decoding device using adaptive pseudo random noise injection during planar mode filtering 有权
    在平面模式滤波期间使用自适应伪随机噪声注入的视频图像编码和解码装置

    公开(公告)号:US09288485B2

    公开(公告)日:2016-03-15

    申请号:US13810586

    申请日:2011-09-12

    摘要: When injecting pseudo random noise to an area centered on a block boundary, a video encoding device and a video decoding device prevent injection of pseudo random noise to an area including a reference image for subsequent planar mode filtering, in order to suppress linear artifacts. The video encoding device includes: an inverse quantization unit for inverse-quantizing a quantization index to obtain a quantization representative value; an inverse frequency transform unit for inverse-transforming the quantization representative value obtained by the inverse quantization unit, to obtain a reconstructed image block; and an adaptive distortion removal filter unit for injecting pseudo random noise to an area centered on a boundary of the reconstructed image block, wherein the adaptive distortion removal filter unit does not inject pseudo random noise to an area including a reference image for planar mode filtering.

    摘要翻译: 当将伪随机噪声注入到以块边界为中心的区域时,视频编码装置和视频解码装置防止将伪随机噪声注入到包括用于随后的平面模式滤波的参考图像的区域上,以便抑制线性伪影。 视频编码装置包括:逆量化单元,用于对量化索引进行逆量化以获得量化代表值; 逆频率变换单元,用于逆变换由所述逆量化单元获得的量化代表值,以获得重构图像块; 以及用于将伪随机噪声注入到以所述重构图像块的边界为中心的区域的自适应失真去除滤波器单元,其中所述自适应失真去除滤波器单元不向包括用于平面模式滤波的参考图像的区域注入伪随机噪声。

    Video decoding apparatus, video coding apparatus, video decoding method, video coding method, and program
    8.
    发明授权
    Video decoding apparatus, video coding apparatus, video decoding method, video coding method, and program 有权
    视频解码装置,视频编码装置,视频解码方法,视频编码方法和程序

    公开(公告)号:US09258560B2

    公开(公告)日:2016-02-09

    申请号:US13808829

    申请日:2011-06-21

    摘要: In the present invention, reconstructed images for prediction are stored in uncompressed reference picture memory and compressed reference picture memory. A video decoder stores in uncompressed reference picture memory a reconstructed image of a frame to be decoded which has been generated on the basis of a prediction, and among reconstructed images which have been stored in the uncompressed reference picture memory, compresses a reconstructed image that will not be used for prediction of the frame to be decoded and stores the image in the compressed reference picture memory. Using the reconstructed images which are stored in the uncompressed reference picture memory and the compressed reference picture memory, the video bitstream is decoded into a video.

    摘要翻译: 在本发明中,用于预测的重建图像被存储在未压缩参考图像存储器和压缩参考图像存储器中。 视频解码器在未压缩的参考图像存储器中存储已经基于预测生成的要解码的帧的重构图像,以及已经存储在未压缩参考图像存储器中的重建图像之中,压缩重建图像, 不用于预测要解码的帧,并将图像存储在压缩参考图像存储器中。 使用存储在未压缩参考图像存储器和压缩参考图像存储器中的重建图像,将视频比特流解码成视频。

    Upper mounting structure for a wheel suspension
    9.
    发明授权
    Upper mounting structure for a wheel suspension 失效
    车轮悬挂的上部安装结构

    公开(公告)号:US5330166A

    公开(公告)日:1994-07-19

    申请号:US873853

    申请日:1992-04-27

    申请人: Hirofumi Aoki

    发明人: Hirofumi Aoki

    CPC分类号: B60G15/068 F16F13/16

    摘要: An upper mounting structure for a wheel suspension includes a coil spring and a strut assembly each of which is adapted to be connected at its lower end with a wheel, while an upper end of the coil spring is coupled with a vehicle body through a spring insulator of high stiffness and an upper end of the strut assembly is coupled with the vehicle body through a strut mounting insulator of low stiffness. The structure further includes an additional insulator connecting between the upper ends of the coil spring and the strut assembly, which additional insulator has higher stiffness than the spring insulator within higher frequency range. Therefore, the strut assembly is capable of absorbing a surge vibration of the coil spring within the higher frequency range in spite of low stiffness of the strut mounting insulator.

    摘要翻译: 用于车轮悬挂的上部安装结构包括螺旋弹簧和支柱组件,每个支撑组件适于在其下端处与轮连接,而螺旋弹簧的上端通过弹簧绝缘体与车体联接 高刚度的上端和支柱组件的上端通过低刚度的支柱安装绝缘体与车体联接。 该结构还包括连接在螺旋弹簧的上端和支柱组件之间的另外的绝缘体,该额外的绝缘体在较高频率范围内具有比弹簧绝缘体更高的刚度。 因此,尽管支柱安装绝缘体的刚度低,但支柱组件能够在更高的频率范围内吸收螺旋弹簧的浪涌振动。

    Active noise control system for automotive vehicle
    10.
    发明授权
    Active noise control system for automotive vehicle 失效
    汽车主动噪声控制系统

    公开(公告)号:US5245664A

    公开(公告)日:1993-09-14

    申请号:US629637

    申请日:1990-12-21

    IPC分类号: B60R11/02 G10K11/178 H04R3/02

    摘要: An active noise control system includes a plurality of vibration pickups for detecting of physical quantities of noise sources, such as vibrations of suspension members of a vehicle, and a plurality of microphones for detecting residual noises transmitted to observing positions. The output signals of the vibration pickups are added up by means of an adder to be input to a controller. The active noise control system also includes a plurality of delay circuits for applying delay times to the respective output signals of the vibration pickups so as to essentially equalize transmitting time of one of the output signals with that of the other output signals. The output signals of the microphones are input to the controller independently of each other. The controller outputs drive signals to a plurality of loudspeakers independent of each other to cause the loudspeakers to produce control sounds so that the control sounds interfere with the noises transmitted from the noise sources to decrease the noises transmitted to the observing positions.

    摘要翻译: 主动噪声控制系统包括多个用于检测噪声源的物理量的振动拾取器,例如车辆的悬挂构件的振动,以及用于检测传递到观察位置的残留噪声的多个麦克风。 振动拾取器的输出信号通过加法器相加以输入到控制器。 有源噪声控制系统还包括多个延迟电路,用于对振动拾取器的相应输出信号施加延迟时间,从而基本上使其中一个输出信号与其它输出信号的传输时间相等。 麦克风的输出信号彼此独立地输入到控制器。 控制器将驱动信号输出到彼此独立的多个扬声器,以使扬声器产生控制声音,使得控制声音干扰从噪声源发送的噪声,以减少发送到观察位置的噪声。