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公开(公告)号:US20180099004A1
公开(公告)日:2018-04-12
申请号:US15567179
申请日:2016-04-15
发明人: Hirofumi TAKEUCHI , Tomohiko USUI , Masahiko KURODA , Masakatsu TAKANASHI , Shinichiro OHNO , Hidekazu TOYOFUKU , Kohei TAHARA , Risako ONODERA
IPC分类号: A61K31/7125 , A61P27/02 , C07H21/02 , A61K48/00 , A61K9/127
CPC分类号: A61K31/7125 , A61K9/127 , A61K48/00 , A61K48/005 , A61K48/0075 , A61P27/02 , C07H21/02 , C12N15/09 , C12N15/113
摘要: The present invention provides a single stranded nucleic acid molecule represented by the following formula (I): (I) (SEQ ID NO: 1) 5′-uagcaccauuugaaaucaguguucc-P- ggaacacugauuucaaauggugcuauu-3′ wherein —P— shows a proline derivative linker represented by the following formula (Ia): an agent for treating corneal diseases such as ocular surface disorders and the like, comprising the single stranded nucleic acid molecule as an active ingredient.
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2.
公开(公告)号:US20180339064A1
公开(公告)日:2018-11-29
申请号:US15771305
申请日:2016-10-28
摘要: The present invention provides a composition containing a single-stranded nucleic acid molecule consisting of a nucleotide sequence shown by 5′-AGCAGAGUACACACAGCAUAUACC-P-GGUAUAUGCUGUGUGUACUCUGCUUC-P-G-3′ (SEQ ID NO: 1) (in the sequence, P is a proline derivative linker represented by (I) in the DESCRIPTION) and a buffer, and having the following features:(a) being in the form of a solution at ambient temperature; and (b) a content of the nucleic acid molecule after storage at 25° C., relative humidity 60% for 4 weeks, of not less than 80% relative to the content at the time of start of the storage.
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公开(公告)号:US20170239194A1
公开(公告)日:2017-08-24
申请号:US15305143
申请日:2015-05-14
发明人: Hirofumi TAKEUCHI , Kohei TAHARA , Atsushi IMAIZUMI , Tsukasa TAKAHASHI , Takato MATSUI , Hitomi OZAWA
IPC分类号: A61K31/12 , A61K36/9066 , A61K9/00
CPC分类号: A61K31/12 , A61K9/0053 , A61K36/9066
摘要: Provided is a composition for oral intake, which exhibits improved oral absorbability of curcumin and/or an analog thereof and can be produced conveniently and inexpensively. A complex of curcumin and/or an analog thereof and a water-soluble cellulose derivative is disclosed.
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