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公开(公告)号：US08529929B2
公开(公告)日：2013-09-10
申请号：US12746157
申请日：2008-12-19
申请人： Hiroki Aoki , Koichi Yoshimura , Hiromori Tsutsumi , Chie Teruyama , Masunori Matsuzaki , Shunichi Kuroda
发明人： Hiroki Aoki , Koichi Yoshimura , Hiromori Tsutsumi , Chie Teruyama , Masunori Matsuzaki , Shunichi Kuroda
CPC分类号： A61L31/16 , A61F2/07 , A61K9/0024 , A61K9/1075 , A61K9/127 , A61K9/513 , A61K47/665 , A61K47/6957 , A61L31/10 , A61L2300/434 , A61L2300/624 , A61L2300/626 , B82Y5/00
摘要： It is a main object of the present invention to provide a drug delivery system in which drugs can be changed or which can be recharged with drugs, which continuously delivers drugs at effective concentrations to local lesional sites in a body and allows the use of drugs for which it has thus far been difficult to achieve effective local concentrations for a variety of reasons and drugs which have been difficult to use due to adverse effects on tissues that are not sites of action. The present invention provides a drug delivery system comprising an indwelling medical device on which a biocompatible material having target molecules on its surface has been coated, and target-recognizing nanocarriers (e.g., bio-nanocapsules, liposomes, liposome preparations, and nanoparticles) in which drugs are encapsulated and which have target-recognizing molecules capable of specifically binding to the target molecules.
摘要翻译： 本发明的主要目的是提供药物递送系统，其中可以改变药物或可以用药物再次充电，药物以有效浓度连续递送到身体中的局部损伤部位，并允许使用药物 由于各种原因和由于不是作用地点的组织的不利影响而难以使用的药物，迄今为止难以实现有效的局部浓度。 本发明提供了一种药物递送系统，其包括其表面上具有目标分子的生物相容性材料已经被涂覆在其上的留置医疗装置，以及目标识别纳米载体（例如，生物纳米胶囊，脂质体，脂质体制剂和纳米颗粒），其中 药物被包封，并且其具有能够特异性结合靶分子的靶标识别分子。
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公开(公告)号：US20100285083A1
公开(公告)日：2010-11-11
申请号：US12746157
申请日：2008-12-19
申请人： Hiroki Aoki , Koichi Yoshimura , Hiromori Tsutsumi , Chie Teruyama , Masunori Matsuzaki , Shunichi Kuroda
发明人： Hiroki Aoki , Koichi Yoshimura , Hiromori Tsutsumi , Chie Teruyama , Masunori Matsuzaki , Shunichi Kuroda
CPC分类号： A61L31/16 , A61F2/07 , A61K9/0024 , A61K9/1075 , A61K9/127 , A61K9/513 , A61K47/665 , A61K47/6957 , A61L31/10 , A61L2300/434 , A61L2300/624 , A61L2300/626 , B82Y5/00
摘要： It is a main object of the present invention to provide a drug delivery system in which drugs can be changed or which can be recharged with drugs, which continuously delivers drugs at effective concentrations to local lesional sites in a body and allows the use of drugs for which it has thus far been difficult to achieve effective local concentrations for a variety of reasons and drugs which have been difficult to use due to adverse effects on tissues that are not sites of action. The present invention provides a drug delivery system comprising an indwelling medical device on which a biocompatible material having target molecules on its surface has been coated, and target-recognizing nanocarriers (e.g., bio-nanocapsules, liposomes, liposome preparations, and nanoparticles) in which drugs are encapsulated and which have target-recognizing molecules capable of specifically binding to the target molecules.
摘要翻译： 本发明的主要目的是提供药物递送系统，其中可以改变药物或可以用药物再次充电，药物以有效浓度连续递送到身体中的局部损伤部位，并允许使用药物 由于各种原因和由于不是作用地点的组织的不利影响而难以使用的药物，迄今为止难以实现有效的局部浓度。 本发明提供了一种药物递送系统，其包括其表面上具有目标分子的生物相容性材料已经被涂覆在其上的留置医疗装置，以及目标识别纳米载体（例如，生物纳米胶囊，脂质体，脂质体制剂和纳米颗粒），其中 药物被包封，并且其具有能够特异性结合靶分子的靶标识别分子。
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