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公开(公告)号：US11986575B2
公开(公告)日：2024-05-21
申请号：US18280275
申请日：2022-03-29
发明人： Kun Sun , Jing Sun , Sun Chen , Kai Bai , Yanan Lu , Lu Wang , Fujun Wang , Fan Zhao , Jihong Huang
CPC分类号： A61L31/16 , A61L31/10 , A61L31/148 , A61L2300/21 , A61L2300/216 , A61L2300/41 , A61L2300/416 , A61L2300/626 , A61L2300/802 , A61L2420/02 , A61L2420/06
摘要： A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.
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公开(公告)号：US20240148944A1
公开(公告)日：2024-05-09
申请号：US18549789
申请日：2022-03-10
CPC分类号： A61L31/005 , A61L31/08 , A61L31/16 , A61L33/0017 , A61L33/18 , A61L2300/412 , A61L2300/42 , A61L2300/626 , A61L2300/64
摘要： The present disclosure provides compositions and methods relating to the use of stents treated with therapeutic biologics for the treatment of cardiovascular diseases and conditions. In particular, the present disclosure provides novel compositions and methods for conjugating therapeutic extracellular vesicles to a stent to not only regulate vascular remodeling and inflammation, but also promote the regeneration of the injured tissue.
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公开(公告)号：US20240115437A1
公开(公告)日：2024-04-11
申请号：US18467750
申请日：2023-09-15
CPC分类号： A61F13/8405 , A61F13/15577 , A61L15/26 , A61L15/46 , A61L15/48 , A61F2013/8408 , A61L2300/232 , A61L2300/626 , A61L2300/802
摘要： This application generally relates to absorbent articles comprising aqueous-based odor control compositions and non-complexed perfume compositions, applied in patterns which do not substantially overlap, and methods of making the same.
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公开(公告)号：US11904068B2
公开(公告)日：2024-02-20
申请号：US17651509
申请日：2022-02-17
IPC分类号： A61B17/34 , A61F6/22 , A61L24/00 , A61L24/06 , A61L27/52 , A61L27/54 , A61K49/22 , A61B8/08 , A61B17/12 , A61B17/42
CPC分类号： A61L24/06 , A61B8/085 , A61B8/0833 , A61B8/0841 , A61B17/12 , A61B17/12022 , A61B17/12186 , A61B17/3403 , A61F6/22 , A61K49/223 , A61K49/226 , A61L24/001 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L27/52 , A61L27/54 , A61B8/0891 , A61B8/481 , A61B8/488 , A61B17/42 , A61B2017/3413 , A61L2300/626 , A61L2400/06 , A61L2430/36
摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
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公开(公告)号：US09937126B2
公开(公告)日：2018-04-10
申请号：US14910616
申请日：2014-10-02
发明人： Jill Helms , Girija Dhamdhere
IPC分类号： A61L27/22 , A61K9/127 , A61K38/17 , A61K35/28 , A61L27/36 , A61L27/38 , A61L27/54 , A61L27/58 , C12N5/077
CPC分类号： A61K9/127 , A61K35/28 , A61K38/1709 , A61L27/227 , A61L27/365 , A61L27/3687 , A61L27/3834 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/412 , A61L2300/604 , A61L2300/626 , A61L2430/02 , C12N5/0669 , C12N2501/415
摘要： Disclosed herein are methods, processes, compositions, and kits for generating bone graft materials for use at a site of bone defect that utilizes a composition which contains liposomal Wnt polypeptide, such as liposomal Wnt3a polypeptide, liposomal Wnt5a polypeptide, or liposomal Wnt10b polypeptide. Also disclosed herein are methods, processes, compositions, and kits for enhancing mammalian bone marrow cells that utilizes a composition which contains liposomal Wnt polypeptide, such as liposomal Wnt3a polypeptide, liposomal Wnt5a polypeptide, or liposomal Wnt10b polypeptide.
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公开(公告)号：US20170368378A1
公开(公告)日：2017-12-28
申请号：US15701207
申请日：2017-09-11
发明人： Brian C. KELLER
CPC分类号： A61Q19/00 , A61K8/585 , A61K8/895 , A61L15/26 , A61L15/44 , A61L26/0019 , A61L26/0066 , A61L2300/626 , C08L83/04
摘要： Provided herein is a scar dressing formulation comprising a blend of a high molecular weight silicone elastomer crosspolymer and a silicone oil, wherein said silicone elastomer crosspolymer is in a volatile fluid. The formulation has a soft, silky feel without being greasy and dries quickly to form a durable, flexible scar dressing.
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公开(公告)号：US20170326169A1
公开(公告)日：2017-11-16
申请号：US15442911
申请日：2017-02-27
IPC分类号： A61K31/722 , A61K47/69 , A61K47/56 , A61L26/00 , A61K9/127 , A61K9/70 , A61K47/61 , A61L27/20
CPC分类号： A61K31/722 , A61K9/127 , A61K9/1271 , A61K9/7007 , A61K47/543 , A61K47/56 , A61K47/61 , A61K47/69 , A61L26/0023 , A61L27/20 , A61L2300/216 , A61L2300/232 , A61L2300/418 , A61L2300/626 , A61L2400/04 , A61L2400/12 , C08L5/08
摘要： The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein.
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8.发明申请公开(公告)号：US20170246432A1
公开(公告)日：2017-08-31
申请号：US15594055
申请日：2017-05-12
IPC分类号： A61M25/10 , A61K9/107 , A61K31/436 , A61L29/14 , A61L29/16
CPC分类号： A61M25/104 , A61K9/107 , A61K31/00 , A61K31/436 , A61L29/146 , A61L29/16 , A61L2300/416 , A61L2300/626 , A61M25/10 , A61M25/1011 , A61M25/1018 , A61M25/10182 , A61M25/10185 , A61M25/10187 , A61M2025/1013 , A61M2025/105 , A61M2025/1075
摘要： Devices and methods for balloon delivery of rapamycin and other hydrophobic compounds to the wall of blood vessels. Balloon catheters, such as those used for balloon angioplasty, are modified with the addition of a reservoir of dry micelles. The micelle preparation is reconstituted and the micelles are mobilized when the aqueous solution used to inflate the balloons is injected into the catheter. The micelles are infused into tissue surrounding the balloon when pressurized fluid within the balloon leaks through the wall of the balloon.
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公开(公告)号：US20170136143A1
公开(公告)日：2017-05-18
申请号：US15349824
申请日：2016-11-11
CPC分类号： A61L24/06 , A61B8/0833 , A61B8/0841 , A61B8/085 , A61B8/0891 , A61B8/481 , A61B8/488 , A61B17/12 , A61B17/12022 , A61B17/12186 , A61B17/3403 , A61B17/42 , A61B2017/3413 , A61F6/22 , A61K49/223 , A61K49/226 , A61L24/001 , A61L24/0015 , A61L24/0031 , A61L24/0036 , A61L27/52 , A61L27/54 , A61L2300/626 , A61L2400/06 , A61L2430/36
摘要： Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.
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10.发明授权Drug delivery system and method of treatment of vascular diseases using photodynamic therapy 有权药物输送系统和使用光动力疗法治疗血管疾病的方法公开(公告)号：US09572795B2
公开(公告)日：2017-02-21
申请号：US13572507
申请日：2012-08-10
申请人： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Jinping Wan
发明人： Syed Hossainy , Dariush Davalian , Mikael Trollsas , John Stankus , Yuet Mei Khong , Jinping Wan
IPC分类号： A61M37/00 , A61K31/409 , A61K9/00 , A61K9/127 , A61K9/51 , A61L29/16 , A61K41/00 , A61M25/00 , A61M25/10
CPC分类号： A61K31/409 , A61K9/0009 , A61K9/0019 , A61K9/1272 , A61K9/5146 , A61K41/0071 , A61L29/16 , A61L2300/224 , A61L2300/626 , A61M25/0045 , A61M25/10 , A61M2025/105 , A61M2025/1086
摘要： This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.
摘要翻译： 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。
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