摘要:
This invention provides an industrially useful process for producing a quinazoline derivative (I) of the general formula: [wherein R1 is hydrogen or halogen; R2 is carboxy or protected carboxy; A is lower alkylene] or its salt on a commercial scale which comprises reacting a compound of the general formula: [wherein R1 is hydrogen or halogen] or its salt with a silylating agent and then with a compound of the general formula: Cl—A—R2 (III) [wherein R2 is carboxy or protected carboxy; A is lower alkylene] or its salt, optionally followed by desilylation.
摘要:
A compound (II) is reacted with a compound (III) or a reactive derivative at the carboxyl group thereof to obtain a compound (IV), which is reacted with a mixed acid anhydride of a compound (V) to prepare a compound (I). In recrystallization of the compound (I), temperature for the recrystallization and/or time for the crystal precipitation is controlled to selectively produce A-form crystals, B-form crystals and C-form crystals of the compound (I).
摘要:
(2R)-1-[3,5-bis(trifluoromethyl)benzoyl]-4-[2-[(2S)-2-(methoxymethyl)morpholino]ethyl]-2-(3-hydroxy-4-methylbenzyl)piperazine dihydrochloride is obtained by debenzylating (2R)-4-benzyl-1-[3,5-bis(trifluoromethyl)-benzoyl]-2-(3-hydroxy-4-methylbenzyl)piperazine, then N-alkylating and converting to hydrochloride.
摘要:
A process for producing a compound of the general formula: ##STR1## wherein R.sup.1 is heterocyclic(lower)alkyl, R.sup.2 is acyl, and R.sup.3 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, which is useful as a medicament or a salt thereof.
摘要:
Novel pentacyclic compounds having antimicrobial and antitumor activity and a process for preparing the same. The pentacyclic compounds are also usefual as intermediates in the production of known tetracyclic antitumor compounds.
摘要:
A photovoltaic ultraviolet sensor comprises a zinc oxide single crystal substrate. On the +c face of the zinc oxide single crystal substrate, an ultraviolet receiver is formed. The exemplary ultraviolet receiver includes a Schottky electrode which, when receiving ultraviolet rays, produces a voltage in cooperation with the zinc oxide single crystal substrate. The ultraviolet sensor does not have any sensitivity to the visible rays. The ultraviolet sensor has a relatively fast response of several microseconds.
摘要:
A glow plug (1) including a metallic shell (2) having a forward end portion (20) having an outer peripheral surface whose diameter increases toward the rear end side with respect to the axial direction, the forward end portion (20) coming into contact with a seat surface (55) formed on an internal combustion engine (50). The outer peripheral surface of the forward end portion (20) includes a first, second and third contact surfaces (21), (22) and (23), respectively, which differ in imaginary line angle from one another, the imaginary line angle of each contact surface being an angle which is formed, as viewed on a cross section including an axis C1, between two straight imaginary lines connecting inflection points of the contact surface at opposite ends of the contact surface. At least one of the contact surfaces is a curved surface which bulges outward.
摘要:
The trihydrates of &bgr;-alanine of the formula Are disclosed. Also method of antogonizing glycoprotein IIb/IIIa activity using these compounds is also disclosed.
摘要:
A glow plug (1) including a metallic shell (2) having a forward end portion (20) having an outer peripheral surface whose diameter increases toward the rear end side with respect to the axial direction, the forward end portion (20) coming into contact with a seat surface (55) formed on an internal combustion engine (50). The outer peripheral surface of the forward end portion (20) includes a first, second and third contact surfaces (21), (22) and (23), respectively, which differ in imaginary line angle from one another, the imaginary line angle of each contact surface being an angle which is formed, as viewed on a cross section including an axis C1, between two straight imaginary lines connecting inflection points of the contact surface at opposite ends of the contact surface. At least one of the contact surfaces is a curved surface which bulges outward.
摘要:
A photovoltaic ultraviolet sensor comprises a zinc oxide single crystal substrate. On the +c face of the zinc oxide single crystal substrate, an ultraviolet receiver is formed. The exemplary ultraviolet receiver includes a Schottky electrode which, when receiving ultraviolet rays, produces a voltage in cooperation with the zinc oxide single crystal substrate. The ultraviolet sensor does not have any sensitivity to the visible rays. The ultraviolet sensor has a relatively fast response of several microseconds.