公开(公告)号：US06319696B1

公开(公告)日：2001-11-20

申请号：US09011762

申请日：1998-04-17

申请人： Hiroko Kishino ,  Masako Izui ,  Yukiko Ono ,  Hisao Ito ,  Osamu Kurahashi

发明人： Hiroko Kishino ,  Masako Izui ,  Yukiko Ono ,  Hisao Ito ,  Osamu Kurahashi

IPC分类号： C12P1308

CPC分类号： C12P13/04

摘要： A microorganism, which has an ability to produce L-amino acid, especially L-phenylalanine, L-tryptophane, L-tyrosine, L-threonine, or L-isoleucine, in which a phosphoenolpyruvate-producing ability is enhanced, is cultivated in a medium so that the L-amino acid is produced and accumulated in the medium to collect the L-amino acid.

摘要翻译： 具有生产L-氨基酸，特别是L-苯丙氨酸，L-色氨酸，L-酪氨酸，L-苏氨酸或L-异亮氨酸的能力的微生物，其中增加了产生磷酸烯醇丙酮酸的能力， 培养基中，使L-氨基酸产生并积累在培养基中以收集L-氨基酸。

公开(公告)号：US4985457A

公开(公告)日：1991-01-15

申请号：US359395

申请日：1989-05-31

申请人： Hiroko Kishino ,  Noritada Matsuo ,  Tohei Takagaki ,  Kazunori Tsushima ,  Toshihiko Yano ,  Yoko Torisu

发明人： Hiroko Kishino ,  Noritada Matsuo ,  Tohei Takagaki ,  Kazunori Tsushima ,  Toshihiko Yano ,  Yoko Torisu

IPC分类号： C07C69/743 ,  A01N53/00 ,  A01N53/02 ,  A01N53/10

CPC分类号： A01N53/00

摘要： This invention relates to novel carboxylic acid esters represented by the formula (I) below, methods for their production and insecticides and/or acaricides containing them as an active ingredient, ##STR1## wherein R.sup.1 represents a C.sub.1-5 alkyl group, a C.sub.2-4 alkenyl group or a C.sub.2-4 alkynyl group; R.sup.2 represents a fluorine atom or a methyl group; and R.sup.3 represents a hydrogen atom or a methyl group.

公开(公告)号：US5998178A

公开(公告)日：1999-12-07

申请号：US452075

申请日：1995-05-26

申请人： Ken-ichi Hashiguchi ,  Hiroko Kishino ,  Nobuharu Tsujimoto ,  Hiroshi Matsui

发明人： Ken-ichi Hashiguchi ,  Hiroko Kishino ,  Nobuharu Tsujimoto ,  Hiroshi Matsui

IPC分类号： C12N1/21 ,  C12N15/52 ,  C12P13/06

CPC分类号： C12P13/06 ,  C12N15/52

摘要： An L-isoleucine-producing bacterium belonging to the genus Escherichia which carries a thrABC operon which comprises a thrA gene coding for aspartokinase I-homoserine dehydrogenase I substantially released from the inhibition by L-threonine and an ilvGMEDA operon which comprises an ilvA gene coding for threonine deaminase substantially released from the inhibition by L-isoleucine and whose region required for attenuation is removed; and an L-isoleucine-producing bacterium belonging to the genus Escherichia carrying the thrABC operon, an lysC gene coding for aspartokinase III substantially released from the inhibition by L-lysine, and the ilvGMEDA operon. The bacteria permit biosynthesis of a sufficient amount of L-isoleucine.

摘要翻译： 属于埃希氏杆菌属的属于埃希氏杆菌属的L-异亮氨酸细菌，其携带thrABC操纵子，其包含基本上由L-苏氨酸抑制的编码天冬氨酸激酶I-高丝氨酸脱氢酶I的thrA基因，以及ilvGMEDA操纵子，该ilvGMEDA操纵子包含编码 苏氨酸脱氨酶基本上从L-异亮氨酸的抑制中释放出去除其衰减所需的区域; 以及属于携带thrABC操纵子的埃希氏菌属的L-异亮氨酸生产细菌，基本上由L-赖氨酸的抑制释放的天冬氨酸激酶III的lysC基因和ilvGMEDA操纵子。 细菌允许生物合成足量的L-异亮氨酸。