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    COENZYME-BINDING GLUCOSE DEHYDROGENASE
    1.
    发明申请
    COENZYME-BINDING GLUCOSE DEHYDROGENASE 审中-公开
    聚苯乙烯葡萄糖脱氢酶

    公开(公告)号：US20100297743A1

    公开(公告)日：2010-11-25

    申请号：US12851668

    申请日：2010-08-06

    申请人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    发明人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    IPC分类号： C12M1/34

    CPC分类号： C12N9/0004 ,  C12Q1/32 ,  C12Q1/54

    摘要： The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding glucose dehydrogenase, and a method and a reagent for measuring employing the coenzyme-binding glucose dehydrogenase. According to the invention, the coenzyme-binding glucose dehydrogenase can be applied to an industrial field, and a use becomes possible also in a material production or analysis including a method for measuring or eliminating glucose in a sample using the coenzyme-binding glucose dehydrogenase as well as a method for producing an organic compound. It became also possible to provide a glucose sensor capable of accurately measuring a blood sugar level. Therefore, it became possible to provide an enzyme having a high utility, such as an ability of being used for modifying a material in the fields of pharmaceuticals, clinical studies and food products.

    摘要翻译： 本发明提供了一种在电子受体存在下催化葡萄糖氧化反应的微生物衍生的可溶性辅酶结合葡萄糖脱氢酶，其麦芽糖活性低至5％以下， 菲咯啉。 本发明还提供了生产辅酶结合葡萄糖脱氢酶的方法，以及使用辅酶结合葡萄糖脱氢酶进行测定的方法和试剂。 根据本发明，辅酶结合葡萄糖脱氢酶可以应用于工业领域，并且也可以在材料生产或分析中使用，包括使用辅酶结合葡萄糖脱氢酶作为测定或消除样品中的葡萄糖的方法 以及作为有机化合物的制造方法。 还可以提供能够精确测量血糖水平的葡萄糖传感器。 因此，可以提供具有高效用的酶，例如用于改变药物，临床研究和食品领域的材料的能力。

    Coenzyme-binding glucose dehydrogenase
    2.
    发明申请
    Coenzyme-binding glucose dehydrogenase 有权

    公开(公告)号：US20060063217A1

    公开(公告)日：2006-03-23

    申请号：US10540025

    申请日：2003-12-24

    申请人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    发明人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    IPC分类号： C12Q1/54 ,  C12N9/02 ,  C12N1/16

    CPC分类号： C12N9/0004 ,  C12Q1/32 ,  C12Q1/54

    摘要： The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding glucose dehydrogenase, and a method and a reagent for measuring employing the coenzyme-binding glucose dehydrogenase. According to the invention, the coenzyme-binding glucose dehydrogenase can be applied to an industrial field, and a use becomes possible also in a material production or analysis including a method for measuring or eliminating glucose in a sample using the coenzyme-binding glucose dehydrogenase as well as a method for producing an organic compound. It became also possible to provide a glucose sensor capable of accurately measuring a blood sugar level. Therefore, it became possible to provide an enzyme having a high utility, such as an ability of being used for modifying a material in the fields of pharmaceuticals, clinical studies and food products.

    Coenzyme-binding glucose dehydrogenase
    3.
    发明授权
    Coenzyme-binding glucose dehydrogenase 有权
    辅酶结合葡萄糖脱氢酶

    公开(公告)号：US07514250B2

    公开(公告)日：2009-04-07

    申请号：US10540025

    申请日：2003-12-24

    申请人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    发明人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    IPC分类号： C12N9/02

    CPC分类号： C12N9/0004 ,  C12Q1/32 ,  C12Q1/54

    摘要： The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding glucose dehydrogenase, and a method and a reagent for measuring employing the coenzyme-binding glucose dehydrogenase. According to the invention, the coenzyme-binding glucose dehydrogenase can be applied to an industrial field, and a use becomes possible also in a material production or analysis including a method for measuring or eliminating glucose in a sample using the coenzyme-binding glucose dehydrogenase as well as a method for producing an organic compound. It became also possible to provide a glucose sensor capable of accurately measuring a blood sugar level. Therefore, it became possible to provide an enzyme having a high utility, such as an ability of being used for modifying a material in the fields of pharmaceuticals, clinical studies and food products.

    摘要翻译： 本发明提供了一种在电子受体存在下催化葡萄糖氧化反应的微生物衍生的可溶性辅酶结合葡萄糖脱氢酶，其麦芽糖活性低至5％以下， 菲咯啉。 本发明还提供了生产辅酶结合葡萄糖脱氢酶的方法，以及使用辅酶结合葡萄糖脱氢酶进行测定的方法和试剂。 根据本发明，辅酶结合葡萄糖脱氢酶可以应用于工业领域，并且也可以在材料生产或分析中使用，包括使用辅酶结合葡萄糖脱氢酶作为测定或消除样品中的葡萄糖的方法 以及作为有机化合物的制造方法。 还可以提供能够精确测量血糖水平的葡萄糖传感器。 因此，可以提供具有高效用的酶，例如用于改变药物，临床研究和食品领域的材料的能力。

    COENZYME-BINDING GLUCOSE DEHYDROGENASE
    4.
    发明申请
    COENZYME-BINDING GLUCOSE DEHYDROGENASE 审中-公开
    聚苯乙烯葡萄糖脱氢酶

    公开(公告)号：US20090176262A1

    公开(公告)日：2009-07-09

    申请号：US12396724

    申请日：2009-03-03

    申请人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    发明人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Tetsunari Morita ,  Mika Kuyama ,  Tokuji Ikeda ,  Kenji Kano ,  Seiya Tsujimura

    IPC分类号： C12Q1/54

    CPC分类号： C12N9/0004 ,  C12Q1/32 ,  C12Q1/54

    摘要： The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding glucose dehydrogenase, and a method and a reagent for measuring employing the coenzyme-binding glucose dehydrogenase. According to the invention, the coenzyme-binding glucose dehydrogenase can be applied to an industrial field, and a use becomes possible also in a material production or analysis including a method for measuring or eliminating glucose in a sample using the coenzyme-binding glucose dehydrogenase as well as a method for producing an organic compound. It became also possible to provide a glucose sensor capable of accurately measuring a blood sugar level. Therefore, it became possible to provide an enzyme having a high utility, such as an ability of being used for modifying a material in the fields of pharmaceuticals, clinical studies and food products.

    摘要翻译： 本发明提供了一种在电子受体存在下催化葡萄糖氧化反应的微生物衍生的可溶性辅酶结合葡萄糖脱氢酶，其麦芽糖活性低至5％以下， 菲咯啉。 本发明还提供了生产辅酶结合葡萄糖脱氢酶的方法，以及使用辅酶结合葡萄糖脱氢酶进行测定的方法和试剂。 根据本发明，辅酶结合葡萄糖脱氢酶可以应用于工业领域，并且也可以在材料生产或分析中使用，包括使用辅酶结合葡萄糖脱氢酶作为测定或消除样品中的葡萄糖的方法 以及作为有机化合物的制造方法。 还可以提供能够精确测量血糖水平的葡萄糖传感器。 因此，可以提供具有高效用的酶，例如用于改变药物，临床研究和食品领域的材料的能力。

    ELECTRON TRANSFER MEDIATOR MODIFIED ENZYME ELECTRODE AND BIOFUEL CELL COMPRISING THE SAME
    6.
    发明申请
    ELECTRON TRANSFER MEDIATOR MODIFIED ENZYME ELECTRODE AND BIOFUEL CELL COMPRISING THE SAME 审中-公开
    电子转移介质改性的酶电极和包含其的生物电池

    公开(公告)号：US20100178572A1

    公开(公告)日：2010-07-15

    申请号：US12440526

    申请日：2007-09-13

    申请人： Hisao Kato ,  Hidetaka Nishikoori ,  Kenji Kano ,  Seiya Tsujimura

    发明人： Hisao Kato ,  Hidetaka Nishikoori ,  Kenji Kano ,  Seiya Tsujimura

    IPC分类号： H01M8/16

    CPC分类号： C12Q1/004 ,  C12Q1/006

    摘要： The present invention provides an electron transfer mediator modified enzyme electrode which can obtain a high current density and exhibit a stable electrode performance by covalently bonding an electron transfer mediator with a surface of a conductive base material constituting the electrode via a specific spacer, and a biofuel cell comprising the electron transfer mediator modified enzyme electrode. An electron transfer mediator modified enzyme electrode comprising a conductive base material connected to an external circuit, an oxidoreductase electron-transferable with the conductive base material and an electron transfer mediator which can mediate electron transfer between the conductive base material and the oxidoreductase, wherein the electron transfer mediator is covalently bonded to the surface of the conductive base material via a spacer containing at least a straight-chain structure, and a biofuel cell comprising the electron transfer mediator modified enzyme electrode.

    摘要翻译： 本发明提供一种电子转移介质修饰酶电极，其可以通过经由特定的间隔物将电子转移介质与构成电极的导电性基材的表面共价键合而获得高电流密度并表现出稳定的电极性能，并且生物燃料 包含电子转移介质修饰酶电极的细胞。 一种电子转移介质修饰酶电极，包括连接到外部电路的导电基底材料，可与导电性基底材料电子转移的氧化还原酶和可介导导电性基材与氧化还原酶之间的电子转移的电子转移介体， 转移介体通过至少含有直链结构的间隔物和包含电子转移介质修饰酶电极的生物燃料电池共价键合到导电性基材的表面。