公开(公告)号：US20120214795A1

公开(公告)日：2012-08-23

申请号：US13392051

申请日：2010-08-25

申请人： Hiroshi Banno ,  Toshio Tanaka ,  Satoshi Sasaki

发明人： Hiroshi Banno ,  Toshio Tanaka ,  Satoshi Sasaki

IPC分类号： A61K31/519 ,  C07D491/048 ,  A61K31/5377 ,  A61P35/00 ,  A61K31/55 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D487/04 ,  C07D495/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

公开(公告)号：US08614208B2

公开(公告)日：2013-12-24

申请号：US13392051

申请日：2010-08-25

申请人： Hiroshi Banno ,  Toshio Tanaka ,  Satoshi Sasaki

发明人： Hiroshi Banno ,  Toshio Tanaka ,  Satoshi Sasaki

IPC分类号： A61K31/519 ,  A61K31/5377 ,  A61P35/00 ,  A61K31/55

CPC分类号： C07D487/04 ,  C07D495/04

摘要： The present invention provides a fused heterocycle derivative having a strong Smo inhibitory activity, and use thereof.Specially, the present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or salt thereof, and a medicament containing the compound or a prodrug thereof, which is an Smo inhibitor or an agent for the prophylaxis or treatment of cancer.

公开(公告)号：US10227337B2

公开(公告)日：2019-03-12

申请号：US13397759

申请日：2012-02-16

申请人： Toshio Tanaka ,  Kohei Watanabe ,  Tsuyoshi Nomoto ,  Mie Okano ,  Taichi Shintou ,  Takeshi Miyazaki ,  Yuhei Nishimura ,  Yasuhito Shimada

发明人： Toshio Tanaka ,  Kohei Watanabe ,  Tsuyoshi Nomoto ,  Mie Okano ,  Taichi Shintou ,  Takeshi Miyazaki ,  Yuhei Nishimura ,  Yasuhito Shimada

IPC分类号： C07D417/06 ,  C07D417/14 ,  C09B23/04 ,  C09B23/06 ,  G01N33/50

摘要： Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).

公开(公告)号：US08743100B2

公开(公告)日：2014-06-03

申请号：US13359036

申请日：2012-01-26

申请人： Toshio Tanaka

发明人： Toshio Tanaka

IPC分类号： G06F3/038

CPC分类号： G09G3/3611 ,  G09G2320/0626 ,  G09G2320/0666 ,  G09G2360/144

摘要： An image display system includes a light sensor operable to change a detection sensitivity. The light sensor outputs a signal according to an intensity of external light exerting an influence on a screen of a display apparatus and to the detection sensitivity. An illuminance acquisition part of a display control apparatus acquires illuminance by the external light based on the signal output from the light sensor. Moreover, a display adjuster adjusts a displaying state of the display apparatus in accordance with the illuminance by the external light acquired by the illuminance acquisition part. A sensitivity changer periodically alternates between a “low sensitivity” of the detection sensitivity and a “high sensitivity” of the detection sensitivity of the light sensor. Thus, even when changing significantly, the illuminance by the external light can be accurately and speedily acquired.

摘要翻译： 图像显示系统包括可操作以改变检测灵敏度的光传感器。 光传感器根据对显示装置的屏幕产生影响的外部光的强度和检测灵敏度输出信号。 显示控制装置的照度采集部基于从光传感器输出的信号，获取外部光的照度。 此外，显示调整器根据由照度采集部获取的外部光照照度来调整显示装置的显示状态。 灵敏度更换器周期性地在检测灵敏度的“低灵敏度”和光传感器的检测灵敏度的“高灵敏度”之间交替。 因此，即使在显着变化的情况下，也能够准确，快速地获取外部光的照度。

公开(公告)号：US08657937B2

公开(公告)日：2014-02-25

申请号：US13125166

申请日：2009-08-27

申请人： Kanji Motegi ,  Ryuuji Akiyama ,  Shunji Haruna ,  Toshio Tanaka

发明人： Kanji Motegi ,  Ryuuji Akiyama ,  Shunji Haruna ,  Toshio Tanaka

IPC分类号： B03C3/47

CPC分类号： B03C3/011 ,  B03C3/08 ,  B03C3/155 ,  B03C3/47

摘要： Each protrusion (42) of a first electrode (40) is formed to have a long plate-like shape extending across a plurality of grid holes (46) of the first electrode (40). Each grid hole (56) of a second electrode (50) is formed to have an elongate shape extending to conform to each corresponding one of the protrusions (42) of the first electrode (40). Protrusions (52) of the second electrode (50) are arranged in the longitudinal direction at end portions (54a) on the long sides of the respective grid holes (56) of the second electrode (50), so as to conform to the grid holes (46) of the first electrode (40).

摘要翻译： 第一电极（40）的每个突起（42）形成为具有延伸穿过第一电极（40）的多个栅极孔（46）的长的板状形状。 第二电极（50）的每个栅格孔（56）形成为具有延伸以与第一电极（40）的每个对应的一个突起（42）相符合的细长形状。 第二电极（50）的突起（52）在第二电极（50）的各个栅极孔（56）的长边的端部（54a）处沿纵向布置，以便与栅格 第一电极（40）的孔（46）。

公开(公告)号：US08508511B2

公开(公告)日：2013-08-13

申请号：US12240122

申请日：2008-09-29

申请人： Toshio Tanaka ,  Tsuyoshi Tanaka

发明人： Toshio Tanaka ,  Tsuyoshi Tanaka

IPC分类号： G06F3/033

CPC分类号： G06F3/0338 ,  G06F3/0362

摘要： An inputting device includes an actuator that can move and rotate, a rotation sensor for detecting a rotation of the actuator, a movement sensor for detecting that the actuator moves to a predetermined position, and a rotation suppressor for preventing the actuator from rotating when the actuator moves to the predetermined position and for allowing the actuator to rotate when the actuator is not positioned at the predetermined position. This input device prevents erroneous operation and performs various operations.

摘要翻译： 输入装置包括能够移动和旋转的致动器，用于检测致动器的旋转的旋转传感器，用于检测致动器移动到预定位置的移动传感器，以及用于当致动器 移动到预定位置并且当致动器未定位在预定位置时允许致动器旋转。 该输入装置防止错误操作并执行各种操作。

公开(公告)号：US20120048792A1

公开(公告)日：2012-03-01

申请号：US13319812

申请日：2010-04-27

申请人： Tomoki Saitou ,  Tsunahiro Ohdou ,  Kanji Motegi ,  Toshio Tanaka

发明人： Tomoki Saitou ,  Tsunahiro Ohdou ,  Kanji Motegi ,  Toshio Tanaka

IPC分类号： C02F1/48

CPC分类号： C02F1/4608 ,  C02F2001/46133 ,  C02F2001/46152 ,  C02F2103/023 ,  C02F2201/4617 ,  F24F3/1423 ,  F24F6/12 ,  F24F2003/1464 ,  F24F2003/1664

摘要： A liquid treatment discharge unit includes a pair of electrodes (52, 53) provided in liquid, a high-voltage DC power supply (61) for applying voltage to the pair of electrodes (52, 53) to generate electric discharge between the pair of electrodes (52, 53), and a current density concentration section (70) for increasing a current density of a current path between the pair of electrodes (52, 53).

摘要翻译： 液体处理放电单元包括设置在液体中的一对电极（52,53），用于向所述一对电极（52,53）施加电压以在所述一对电极之间产生放电的高压DC电源（61） 电极（52,53）和用于增加所述一对电极（52,53）之间的电流通路的电流密度的电流密度浓度部（70）。

公开(公告)号：US08090627B2

公开(公告)日：2012-01-03

申请号：US11386020

申请日：2006-03-21

申请人： Atsushi Nagahara ,  Toshio Tanaka

发明人： Atsushi Nagahara ,  Toshio Tanaka

IPC分类号： G06Q30/00

CPC分类号： G06Q10/02 ,  G06Q10/06 ,  G06Q30/0601 ,  G06Q30/0633 ,  G06Q30/0635

摘要： A printing system includes a client apparatus which deals with printing data and a server apparatus which is connected to the client apparatus to communicate therewith. The client apparatus includes: a correction data request transmitting unit which requests the server apparatus to transmit correction data used for correcting the printing data; a correction data receiving unit which receives predetermined correction data transmitted; a billing information receiving unit; and a billing unit which performs a predetermined process on the basis of the billing information received by the billing information receiving unit. The server apparatus includes: a correction data request receiving unit; a correction data acquiring unit which acquires, from a correction data storage unit, predetermined correction data corresponding to the request to transmit the correction data received by the correction data request receiving unit; a correction data transmitting unit; a charge calculating unit; and a charge notifying unit.

摘要翻译： 打印系统包括处理打印数据的客户端设备和连接到客户端设备进行通信的服务器设备。 客户端装置包括：校正数据请求发送单元，其请求服务器装置发送用于校正打印数据的校正数据; 校正数据接收单元，其接收发送的预定校正数据; 记帐信息接收单元; 以及计费单元，其基于由计费信息接收单元接收的计费信息执行预定处理。 服务器装置包括：校正数据请求接收单元; 校正数据获取单元，从校正数据存储单元获取与发送由校正数据请求接收单元接收的校正数据的请求相对应的预定校正数据; 校正数据发送单元; 计费单元; 和充电通知单元。

公开(公告)号：US20110197768A1

公开(公告)日：2011-08-18

申请号：US13125166

申请日：2009-08-27

申请人： Kanji Motegi ,  Ryuuji Akiyama ,  Shunji Haruna ,  Toshio Tanaka

发明人： Kanji Motegi ,  Ryuuji Akiyama ,  Shunji Haruna ,  Toshio Tanaka

IPC分类号： B03C3/47

CPC分类号： B03C3/011 ,  B03C3/08 ,  B03C3/155 ,  B03C3/47

摘要： Each protrusion (42) of a first electrode (40) is formed to have a long plate-like shape extending across a plurality of grid holes (46) of the first electrode (40). Each grid hole (56) of a second electrode (50) is formed to have an elongate shape extending to conform to each corresponding one of the protrusions (42) of the first electrode (40). Protrusions (52) of the second electrode (50) are arranged in the longitudinal direction at end portions (54a) on the long sides of the respective grid holes (56) of the second electrode (50), so as to conform to the grid holes (46) of the first electrode (40).

摘要翻译： 第一电极（40）的每个突起（42）形成为具有延伸穿过第一电极（40）的多个栅极孔（46）的长的板状形状。 第二电极（50）的每个栅格孔（56）形成为具有延伸以与第一电极（40）的每个对应的一个突起（42）相符合的细长形状。 第二电极（50）的突起（52）在第二电极（50）的各个栅极孔（56）的长边的端部（54a）处沿纵向布置，以便与栅格 第一电极（40）的孔（46）。

公开(公告)号：US20110189096A1

公开(公告)日：2011-08-04

申请号：US13084997

申请日：2011-04-12

申请人： Kohei Watanabe ,  Taichi Shintou ,  Tsuyoshi Nomoto ,  Takeshi Miyazaki ,  Mie Okano ,  Toshio Tanaka ,  Yuhei Nishimura ,  Yasuhito Shimada

发明人： Kohei Watanabe ,  Taichi Shintou ,  Tsuyoshi Nomoto ,  Takeshi Miyazaki ,  Mie Okano ,  Toshio Tanaka ,  Yuhei Nishimura ,  Yasuhito Shimada

IPC分类号： A61K49/00 ,  C07D221/18 ,  C07D491/147 ,  C07D221/14 ,  C07D417/10 ,  C07D417/06

CPC分类号： A61K49/0032 ,  A61K49/0039 ,  A61K49/006 ,  C07D417/06 ,  G01N33/50 ,  G01N33/58 ,  G01T1/161

摘要： To provide a central nervous system tissue-labeling composition labeling the central nervous tissue system. Also, another object of the present invention is to provide a method for non-invasively labeling the central nervous tissue system. Further, another object of the present invention is to provide a screening method using the above central nervous system tissue-labeling composition. A central nervous system tissue-labeling composition containing, as an active ingredient, at least one of compounds represented by the general formula (1) or (7).

摘要翻译： 提供标记中枢神经组织系统的中枢神经系统组织标记组合物。 此外，本发明的另一个目的是提供一种非侵入性标记中枢神经组织系统的方法。 此外，本发明的另一个目的是提供一种使用上述中枢神经系统组织标记组合物的筛选方法。 一种中枢神经系统组织标记组合物，含有由通式（1）或（7）表示的至少一种化合物作为活性成分。