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公开(公告)号:US10946109B2
公开(公告)日:2021-03-16
申请号:US15488952
申请日:2017-04-17
申请人: Hiroshi Maeda
发明人: Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
IPC分类号: A61B1/04 , A61K49/00 , A61B1/313 , G01N21/33 , G01N21/64 , A61K41/00 , G01N33/574 , G01N33/58 , A61K47/58
摘要: The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatible macromolecule.
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公开(公告)号:US09937152B2
公开(公告)日:2018-04-10
申请号:US15037723
申请日:2014-11-19
申请人: Hiroshi Maeda
发明人: Hiroshi Maeda , Hideaki Nakamura , Jun Fang
IPC分类号: C08F222/06 , C08F8/44 , C08F8/42 , C08F8/34 , C08F8/12 , C08F8/32 , C08F8/30 , A61K38/00 , C07K14/575 , A61K31/409 , A61K31/69 , A61K31/704 , C08F220/04 , A61K47/58
CPC分类号: A61K31/409 , A61K31/69 , A61K31/704 , A61K38/00 , A61K47/58 , C07K14/575 , C08F8/12 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C08F8/44 , C08F220/04 , C08F222/06 , C08F2800/10 , C08F222/08 , C08F212/08 , C08F222/02
摘要: The present invention provides a group of novel SMA derivatives and a covalent conjugate of the derivatives and an active substance. More specifically, the present invention provides: an SMA derivative which contains (i) a styrene-maleic acid copolymer (SMA) and (ii) a side chain (b) that contains a functional group (a) selected from among —NH2, —SH, —OH, —COOH, —NH—(C═NH)—NH2 and —C(CH2—OH)3 and introduced into a carboxyl group of a maleic acid residue of the SMA via an amide bond or an ester bond, and wherein when a plurality of side chain (b) is introduced into the SMA, the side chains (b) may be identical or different from each other; and a conjugate of this SMA derivative and an active substance.
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公开(公告)号:US09636426B2
公开(公告)日:2017-05-02
申请号:US14342879
申请日:2012-09-05
申请人: Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
发明人: Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
IPC分类号: A61Q5/12 , A61K49/00 , A61B1/04 , A61B1/313 , G01N33/574 , G01N33/58 , A61K41/00 , G01N21/33 , G01N21/64 , A61K47/48
CPC分类号: A61K49/0082 , A61B1/043 , A61B1/313 , A61K41/0057 , A61K41/0071 , A61K47/58 , A61K49/0017 , A61K49/0034 , A61K49/005 , A61K49/0054 , G01N21/33 , G01N21/6447 , G01N33/574 , G01N33/582 , G01N33/585
摘要: The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.
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公开(公告)号:US20140294735A1
公开(公告)日:2014-10-02
申请号:US14342879
申请日:2012-09-05
申请人: Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
发明人: Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
IPC分类号: A61K49/00
CPC分类号: A61K49/0082 , A61B1/043 , A61B1/313 , A61K41/0057 , A61K41/0071 , A61K47/58 , A61K49/0017 , A61K49/0034 , A61K49/005 , A61K49/0054 , G01N21/33 , G01N21/6447 , G01N33/574 , G01N33/582 , G01N33/585
摘要: The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.
摘要翻译: 本发明提供了一种用于有效荧光检测(可视化)肿瘤或用于实现荧光检测和光动力学治疗的荧光分子探针,更具体地,本发明提供了用于肿瘤荧光检测的大分子荧光分子探针,其包含荧光 分子和生物相容性大分子。
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