公开(公告)号：US20090048310A1

公开(公告)日：2009-02-19

申请号：US11815365

申请日：2006-02-01

申请人： Hiroshi Suzuki ,  Koji Chono ,  Kenji Sudo

发明人： Hiroshi Suzuki ,  Koji Chono ,  Kenji Sudo

IPC分类号： A61K31/4245 ,  A61P31/22 ,  C07D409/00 ,  C07D277/62 ,  C07D277/00 ,  C07D271/06

CPC分类号： A61K31/422 ,  A61K31/4245 ,  C07D413/12

摘要： [Problems] To provide an agent useful for the prevention or treatment of various diseases associated with the infection with acyclovir-resistant viruses of the family Herpesviridae, specifically various infectious caused by herpes viruses, such as varicella associated with varicella-zoster virus infection, herpes zoster associated with recurrent infection with latent varicella-zoster virus, and herpes labialis, herpes encephalitis and genital herpes associated with HSV-1 and HSV-2 infection, and the like.[Means for Solving Problems] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phenyl group is substituted at position 4 by a specific 5- or 6-membered heteroaryl group. This derivative has an excellent anti-viral activity against acyclovir-resistant herpes viruses and, therefore, is effective for the treatment of the diseases as mentioned above.

摘要翻译： [问题]提供可用于预防或治疗与疱疹病毒科疱疹病毒的无环鸟苷抗性病毒感染有关的各种疾病的药剂，特别是由疱疹病毒引起的各种感染性疾病，例如与水痘带状疱疹病毒感染相关的水痘，疱疹 与潜伏性水痘带状疱疹病毒复发感染的带状疱疹，唇疱疹，与HSV-1和HSV-2感染相关的疱疹性脑炎和生殖器疱疹等。 [解决问题的手段]将苯基在4位被特定5取代的N- [2 - [（4-取代苯基）氨基] -2-氧代乙基]四氢-2H-噻喃-4-甲酰胺衍生物 - 或6-元杂芳基。 该衍生物对抗阿昔洛韦抗性疱疹病毒具有优异的抗病毒活性，因此对于如上所述的疾病的治疗是有效的。

公开(公告)号：US20050032855A1

公开(公告)日：2005-02-10

申请号：US10912232

申请日：2004-08-06

申请人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

发明人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

IPC分类号： A61P31/22 ,  C07D335/02 ,  C07D413/12 ,  A61K31/4245 ,  A61K31/422 ,  C07D413/02

CPC分类号： C07D335/02 ,  C07D413/12

摘要： A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-{2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

公开(公告)号：US20060229295A1

公开(公告)日：2006-10-12

申请号：US10567565

申请日：2004-08-05

申请人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

发明人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

IPC分类号： A61K31/55 ,  A61K31/551 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/428 ,  A61K31/422

CPC分类号： C07D335/02 ,  C07D413/12

摘要： There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. An N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

摘要翻译： 提供药物，特别是可用于预防或治疗涉及疱疹病毒家族病毒感染的各种疾病的新型化合物，特别是各种疱疹病毒感染如通过水痘带状疱疹病毒的水痘（水痘），水痘带状疱疹经由复发 通过HSV-1和生殖器疱疹通过HSV-2感染感染潜伏性水痘带状疱疹病毒，唇疱疹和疱疹脑炎。 N-（2 - [（4-取代苯基）氨基] -2-氧代乙基}四氢-2H-噻喃-4-甲酰胺衍生物，其苯基在4位被特定的5或6元杂芳基取代 基团和其盐具有有效的抗病毒活性，并且以低剂量口服给药能够治疗上述疾病。

公开(公告)号：US06903125B2

公开(公告)日：2005-06-07

申请号：US10912232

申请日：2004-08-06

申请人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

发明人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

IPC分类号： A61P31/22 ,  C07D335/02 ,  C07D413/12 ,  A61K31/41 ,  C07D271/06

CPC分类号： C07D335/02 ,  C07D413/12

摘要： A pharmaceutical drug, particularly a novel compound useful for the prophylaxis or therapeutic treatment of various diseases involving infections with viruses of the Herpesviridae family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection. N-{2-[(4-Substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative where the phenyl group is substituted at position 4 with a specific five-membered or 6-membered heteroaryl group, has such great anti-virus activity that the oral dosing thereof at a low dose enabled the therapeutic treatment of the diseases.

摘要翻译： 一种药物，特别是可用于预防或治疗涉及疱疹病毒科家族病毒感染的各种疾病的新型化合物，特别是各种疱疹病毒感染如通过水痘带状疱疹病毒的水痘（水痘），水痘带状疱疹通过潜在的复发性感染 水痘带状疱疹病毒，通过HSV-1和生殖器疱疹通过HSV-2感染的唇疱疹和疱疹脑炎。 N- {2 - [（4-取代的苯基）氨基] -2-氧代乙基}四氢-2H-噻喃-4-甲酰胺衍生物，其中苯基在4位被特定的5元或6元杂芳基取代 具有如此巨大的抗病毒活性，以低剂量的口服给药能够治疗疾病。

公开(公告)号：US07465748B2

公开(公告)日：2008-12-16

申请号：US10567565

申请日：2004-08-05

申请人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

发明人： Toru Kontani ,  Junji Miyata ,  Wataru Hamaguchi ,  Tomoaki Kawano ,  Akio Kamikawa ,  Hiroshi Suzuki ,  Kenji Sudo

IPC分类号： A61K31/41 ,  C07D271/06

CPC分类号： C07D335/02 ,  C07D413/12

摘要： There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus family, specifically various herpesvirus infections such as varicella (chicken pox) via varicella zoster virus, varicella zoster via recurrent infection with latent varicella zoster virus, herpes labialis and herpes encephalitis via HSV-1 and genital herpes via HSV-2 infection.An N-{2-[(4-substituted phenyl)amino]-2-oxoethyl}tetrahydro-2H-thiopyran-4-carboxamide derivative, of which phenyl group is substituted at position 4 with a specific 5- or 6-membered heteroaryl group, and a salt thereof have an effective anti-virus activity, and the oral administration thereof at a low dose enabled the therapeutic treatment of the above diseases.

摘要翻译： 提供药物，特别是可用于预防或治疗涉及疱疹病毒家族病毒感染的各种疾病的新型化合物，特别是各种疱疹病毒感染如通过水痘带状疱疹病毒的水痘（水痘），水痘带状疱疹经由复发 通过HSV-1和生殖器疱疹通过HSV-2感染感染潜伏性水痘带状疱疹病毒，唇疱疹和疱疹脑炎。 N-（2 - [（4-取代苯基）氨基] -2-氧代乙基}四氢-2H-噻喃-4-甲酰胺衍生物，其苯基在4位被特定的5或6元杂芳基取代 基团和其盐具有有效的抗病毒活性，并且以低剂量口服给药能够治疗上述疾病。

公开(公告)号：US20090030049A1

公开(公告)日：2009-01-29

申请号：US11815390

申请日：2006-02-01

申请人： Hiroshi Suzuki ,  Kenji Sudo

发明人： Hiroshi Suzuki ,  Kenji Sudo

IPC分类号： A61K31/4245 ,  A61K31/422 ,  A61P31/22

CPC分类号： C07D413/12 ,  A61K31/422 ,  A61K31/4245

摘要： [PROBLEMS] To provide a medicament useful for the treatment of genital herpes after the development of lesions.[MEANS FOR SOLVING PROBLEMS] An N-[2-[(4-substituted phenyl)amino]-2-oxoethyl]tetrahydro-2H-thiopyran-4-carboxamide derivative in which the phenyl group is substituted at position 4 by a specific 5- or 6-membered heteroaryl group has an excellent anti-herpesvirus effect and can exert excellent therapeutic effect on genital herpes after the development of lesions. Therefore, the compound is useful for the treatment of genital herpes after the development of lesions.

摘要翻译： [问题]提供可用于在发展病变后治疗生殖器疱疹的药物。 解决问题的方法N-苯并[4 - 取代苯基]氨基] -2-氧代乙基]四氢-2H-噻喃-4-甲酰胺衍生物，其中苯基在4位被特异性5取代 - 或6元杂芳基具有优异的抗疱疹病毒作用，并且可以在病变发展后对生殖器疱疹发挥优异的治疗作用。 因此，该化合物在病变发展后可用于治疗生殖器疱疹。

公开(公告)号：US20090042915A1

公开(公告)日：2009-02-12

申请号：US11815375

申请日：2006-02-01

申请人： Hiroshi Suzuki ,  Kenji Sudo

发明人： Hiroshi Suzuki ,  Kenji Sudo

IPC分类号： A61K31/422 ,  A61K31/4245 ,  A61K31/522 ,  A61P31/22

CPC分类号： C07D413/12 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/52 ,  A61K31/522 ,  A61K45/06 ,  A61K2300/00

摘要： [Problems] To provide a medicament, particularly a pharmaceutical composition useful for preventing or treating a variety of diseases caused by infection of a virus of the Herpesviridae family.[Means for Solving Problems] The present invention relates to an anti-herpesvirus agent characterized by combining a helicase-primase inhibitor with a polymerase inhibitor. By combining the polymerase inhibitor with the helicase-primase inhibitor having different functional mechanisms, the anti-herpesvirus agent of the present invention achieves an extremely superior anti-herpesvirus activity compared with conventional administration of a polymerase inhibitor alone. Therefore, it is particularly effective in a case in which a sufficient therapeutic effect cannot be achieved only with a polymerase inhibitor. Further, since the doses of both agents can be kept low, it is also possible to perform treatment by lowering the effect of an adverse reaction to be concerned.

摘要翻译： [问题]提供一种药物，特别是可用于预防或治疗由疱疹病毒科家族病毒感染引起的各种疾病的药物组合物。 解决问题的手段本发明涉及抗疱疹病毒药物，其特征在于将解旋酶抑制剂与聚合酶抑制剂组合。 通过将聚合酶抑制剂与具有不同功能机制的解旋酶抑制剂相结合，本发明的抗疱疹病毒剂与单独使用聚合酶抑制剂相比，具有非常优异的抗疱疹病毒活性。 因此，仅在聚合酶抑制剂不能达到足够的治疗效果的情况下才有效。 此外，由于可以将两种药剂的剂量保持在较低水平，所以也可以通过降低所涉及的不良反应的效果来进行治疗。

公开(公告)号：US4645688A

公开(公告)日：1987-02-24

申请号：US679460

申请日：1984-12-07

申请人： Daisuke Makino ,  Hidetaka Sato ,  Hiroshi Suzuki ,  Shun-ichiro Uchimura ,  Hiroshi Suzuki

发明人： Daisuke Makino ,  Hidetaka Sato ,  Hiroshi Suzuki ,  Shun-ichiro Uchimura ,  Hiroshi Suzuki

IPC分类号： C08G73/10 ,  C08G77/54 ,  H01B3/30 ,  H01B3/46 ,  H01L23/29 ,  B05D5/12

CPC分类号： C08G77/54 ,  C08G73/1042 ,  C08G73/106 ,  H01B3/303 ,  H01B3/46 ,  H01L23/296 ,  H01L2924/0002

摘要： There are disclosed a composition for protective coating material, preferably for a protective coating material of a semiconductor device which is constituted of principal elements of a semiconductor memory element, an encapsulating layer containing an inorganic material for encapsulating said element and a layer of a cured protective coating material arranged between said memory element and said encapsulating layer, which is composed of a polyamide acid obtained by the reaction of a diaminosiloxane, an organic diamine containing no silicon and an organic tetrabasic acid dianhydride, and a semiconductor device having a layer of a cured protective coating material composed of a polyimide-silicone copolymer obtained by dehydrating ring closure of the above-mentioned polyamide acid.

摘要翻译： 公开了一种用于保护涂层材料的组合物，优选用于半导体器件的保护涂层材料，其由半导体存储元件的主要元件，包含用于封装所述元件的无机材料的封装层和固化保护层 布置在所述存储元件和所述封装层之间的涂料，其由通过二氨基硅氧烷，不含硅的有机二胺和有机四元酸二酐反应获得的聚酰胺酸和具有固化的层的半导体器件 由通过上述聚酰胺酸脱水闭环得到的聚酰亚胺 - 硅氧烷共聚物构成的保护涂料。

公开(公告)号：US4511705A

公开(公告)日：1985-04-16

申请号：US568284

申请日：1984-01-05

申请人： Daisuke Makino ,  Hidetaka Sato ,  Hiroshi Suzuki ,  Shun-ichiro Uchimura ,  Hiroshi Suzuki

发明人： Daisuke Makino ,  Hidetaka Sato ,  Hiroshi Suzuki ,  Shun-ichiro Uchimura ,  Hiroshi Suzuki

IPC分类号： C08G73/10 ,  C08G77/54 ,  H01B3/30 ,  H01B3/46 ,  H01L23/29 ,  C08G77/04

CPC分类号： C08G77/54 ,  C08G73/1042 ,  C08G73/106 ,  H01B3/303 ,  H01B3/46 ,  H01L23/296 ,  H01L2924/0002

摘要： There are disclosed a composition for protective coating material, preferably for a protective coating material of a semiconductor device which is constituted of principal elements of a semiconductor memory element, an encapsulating layer containing an inorganic material for encapsulating said element and a layer of a cured protective coating material arranged between said memory element and said encapsulating layer, which is composed of a polyamide acid obtained by the reaction of a diaminosiloxane, an organic diamine containing no silicon and an organic tetrabasic acid dianhydride, and a semiconductor device having a layer of a cured protective coating material composed of a polyimide-silicone copolymer obtained by dehydrating ring closure of the above-mentioned polyamide acid.

公开(公告)号：US09871933B2

公开(公告)日：2018-01-16

申请号：US15370061

申请日：2016-12-06

申请人： Hiroshi Suzuki ,  Takao Suzuki

发明人： Hiroshi Suzuki ,  Takao Suzuki

IPC分类号： H04N1/00 ,  G06F3/12 ,  G06K15/02

CPC分类号： H04N1/0044 ,  G06F3/1208 ,  G06F3/1256 ,  G06F3/1294 ,  G06K15/1813 ,  G06K15/1822 ,  H04N1/00204 ,  H04N1/00344 ,  H04N2201/0039 ,  H04N2201/0094

摘要： An information processing apparatus is for generating image data by using drawing information for drawing an image. The information processing apparatus includes a print data acquirer configured to acquire print data including the drawing information from outside; a request acceptor configured to accept a request to display the image data of any page in the print data; a reader configured to read specific drawing information of pages in the print data up to a page before the any page accepted by the request acceptor, from a drawing information storage storing the specific drawing information, which is the drawing information that may be applied to the image data of pages after a page in which the drawing information is described, among the drawing information included in the print data; and a generator configured to generate the image data of the any page by applying the read specific drawing information.