利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

12 条记录 (耗时 0.023 秒)

    Method for producing pyrimidinylpyrazole compounds
    1.
    发明授权
    Method for producing pyrimidinylpyrazole compounds 有权
    嘧啶基吡唑化合物的制备方法

    公开(公告)号：US08592582B2

    公开(公告)日：2013-11-26

    申请号：US13520203

    申请日：2011-01-05

    申请人： Hirotada Fukunishi ,  Naoto Hanyu ,  Masaru Suetsugu ,  Takuya Hiruma

    发明人： Hirotada Fukunishi ,  Naoto Hanyu ,  Masaru Suetsugu ,  Takuya Hiruma

    IPC分类号： C07D403/04

    CPC分类号： C07D403/04

    摘要： The present invention provides a method for producing a pyrimidinylpyrazole compound (1), wherein aminoguanidine (2) or its salt is reacted with a β-diketone compound (3) to produce the pyrimidinylpyrazole compound: wherein R1 and R3 are each independently an alkyl group having 1 to 4 carbon atoms, and R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms. The method is excellent in the environmental compatibility and economic efficiency.

    摘要翻译： 本发明提供一种制备嘧啶基吡唑化合物（1）的方法，其中氨基胍（2）或其盐与β-二酮化合物（3）反应以产生嘧啶基吡唑化合物：其中R 1和R 3各自独立地为烷基 具有1至4个碳原子，并且R 2是氢原子或具有1至4个碳原子的烷基。 该方法在环境兼容性和经济效益上优异。

    Method For Producing Pyrimidinylpyrazole Compounds
    2.
    发明申请
    Method For Producing Pyrimidinylpyrazole Compounds 有权
    产生嘧啶基吡唑化合物的方法

    公开(公告)号：US20120283441A1

    公开(公告)日：2012-11-08

    申请号：US13520203

    申请日：2011-01-05

    申请人： Hirotada Fukunishi ,  Naoto Hanyu ,  Masaru Suetsugu ,  Takuya Hiruma

    发明人： Hirotada Fukunishi ,  Naoto Hanyu ,  Masaru Suetsugu ,  Takuya Hiruma

    IPC分类号： C07D403/04

    CPC分类号： C07D403/04

    摘要： The present invention provides a method for producing a pyrimidinylpyrazole compound (1), wherein aminoguanidine (2) or its salt is reacted with a β-diketone compound (3) to produce the pyrimidinylpyrazole compound: wherein R1 and R3 are each independently an alkyl group having 1 to 4 carbon atoms, and R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms. The method is excellent in the environmental compatibility and economic efficiency.

    摘要翻译： 本发明提供一种嘧啶基吡唑化合物（1）的制备方法，其中使氨基胍（2）或其盐与β-二酮化合物（3）反应以产生嘧啶基吡唑化合物：其中R 1和R 3各自独立地为烷基 具有1至4个碳原子的基团，并且R 2是氢原子或具有1至4个碳原子的烷基。 该方法在环境兼容性和经济效益上优异。

    Whitening agent and skin external preparation
    3.
    发明授权
    Whitening agent and skin external preparation 有权
    美白剂和皮肤外用剂

    公开(公告)号：US08563552B2

    公开(公告)日：2013-10-22

    申请号：US12866250

    申请日：2009-02-06

    申请人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    发明人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    IPC分类号： A61K31/535

    CPC分类号： A61K31/4439 ,  A61K8/4946 ,  A61K31/506 ,  A61Q19/02

    摘要： The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein X1, X2, and X3 are each CR2 or N; R1, R2, and R3 are each H, C1-6 alkyl, C1-6 alkoxy, SH, OH, or NRbRc, wherein Rb and Rc are each H, C1-6 alkyl, or hydroxy-C1-6 alkyl, or NRbRc forms a saturated or unsaturated 5- or 6-membered hetero ring; and B is a substituted or unsubstituted pyrazole, imidazole, pyridine, or piperidine; with the proviso that at least one of R1, R3, R4, and R6 is a group other than C1-3 alkyl in the case where X1═X2═Y1═N and X3═CR2.

    摘要翻译： 本发明提供对黑素生成具有优异抑制作用并可用作增白剂的化合物和含有该化合物的皮肤外用制剂。 本发明的增白剂作为活性成分，含有式（1）表示的化合物或其药理学上可接受的盐：其中，X1，X2，X3各自为CR2或N; R 1，R 2和R 3各自为H，C 1-6烷基，C 1-6烷氧基，SH，OH或NR b R c，其中R b和R c各自为H，C 1-6烷基或羟基-C 1-6烷基，或NR b R c 形成饱和或不饱和的5-或6-元杂环; B是取代或未取代的吡唑，咪唑，吡啶或哌啶; 条件是在X1 = X2 = Y1 = N和X3 = CR2的情况下，R 1，R 3，R 4和R 6中的至少一个为不是C 1-3烷基的基团。

    Phenylacetonitrile derivatives and hair tonics and external preparations for skin containing the derivatives
    5.
    发明申请
    Phenylacetonitrile derivatives and hair tonics and external preparations for skin containing the derivatives 审中-公开
    苯乙腈衍生物和头发滋养物以及含有衍生物的皮肤外用制剂

    公开(公告)号：US20050176822A1

    公开(公告)日：2005-08-11

    申请号：US10509246

    申请日：2003-03-28

    申请人： Naoto Hanyu ,  Koji Kobayashi ,  Masahiro Tajima ,  Akihiro Ishino

    发明人： Naoto Hanyu ,  Koji Kobayashi ,  Masahiro Tajima ,  Akihiro Ishino

    IPC分类号： A61K8/40 ,  A61K8/41 ,  A61P17/14 ,  A61Q7/00 ,  A61Q19/00 ,  C07C255/42 ,  C07C255/43 ,  A61K31/277

    CPC分类号： A61Q19/00 ,  A61K8/40 ,  A61K8/41 ,  A61Q7/00 ,  C07C255/42 ,  C07C255/43

    摘要： A hair growth promoting composition comprising, as an effective ingredient, a phenylacetonitrile derivative or a pharmacologically acceptable salt thereof expressed by the following Formula (I): wherein each of R1 and R2 is hydrogen atom, a C1-10 alkyl group, a C2-10 alkenyl group or C2-10 acyl group, or NR1R2 may be a heterocycle having 3-7 members; R3 is a C1-5 alkyl group; and each of R4, R5 and R6 is hydrogen atom or a C1-4 alkoxy group. The present invention provides a hair growth promoting composition having excellent effects on promoting hair regrowth, preventing or inhibiting hair loss, and the like in human by compounding above-specified phenylacetonitrile derivative as a effective ingredient thereto.

    摘要翻译： 一种毛发生长促进组合物，其包含由下式（I）表示的苯乙腈衍生物或其药理学上可接受的盐作为有效成分：其中R 1和R 2各自表示， SUP>是氢原子，C 1-10烷基，C 2-10链烯基或C 2-10酰基， 或NR 1 R 2可以是具有3-7个成员的杂环; R 3是C 1-5烷基; R 4，R 5和R 6中的每一个为氢原子或C 1-4烷氧基 。 本发明提供一种通过将上述规定的苯乙腈衍生物作为有效成分配合而具有对促进毛发再生，预防或抑制脱发等的效果的毛发生长促进组合物。

    Whitening Agent And Skin External Preparation
    7.
    发明申请
    Whitening Agent And Skin External Preparation 有权
    美白剂和皮肤外用剂

    公开(公告)号：US20110003817A1

    公开(公告)日：2011-01-06

    申请号：US12866250

    申请日：2009-02-06

    申请人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    发明人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    IPC分类号： A61K8/49 ,  C07D401/04 ,  C07D413/14 ,  C07D403/04 ,  C07D231/12 ,  A61Q19/02

    CPC分类号： A61K31/4439 ,  A61K8/4946 ,  A61K31/506 ,  A61Q19/02

    摘要： The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein X1, X2, and X3 are each CR2 or N; R1, R2, and R3 are each H, C1-6 alkyl, C1-6 alkoxy, SH, OH, or NRbRc, wherein Rb and Rc are each H, C1-6 alkyl, or hydroxy-C1-6 alkyl, or NRbRc forms a saturated or unsaturated 5- or 6-membered hetero ring; and B is a substituted or unsubstituted pyrazole, imidazole, pyridine, or piperidine; with the proviso that at least one of R1, R3, R4, and R6 is a group other than C1-3 alkyl in the case where X1═X2═Y1═N and X3═CR2.

    摘要翻译： 本发明提供对黑素生成具有优异抑制作用并可用作增白剂的化合物和含有该化合物的皮肤外用制剂。 本发明的增白剂作为活性成分，含有式（1）表示的化合物或其药理学上可接受的盐：其中，X1，X2，X3各自为CR2或N; R 1，R 2和R 3各自为H，C 1-6烷基，C 1-6烷氧基，SH，OH或NR b R c，其中R b和R c各自为H，C 1-6烷基或羟基-C 1-6烷基，或NR b R c 形成饱和或不饱和的5-或6-元杂环; B是取代或未取代的吡唑，咪唑，吡啶或哌啶; 条件是在X1 = X2 = Y1 = N和X3 = CR2的情况下，R 1，R 3，R 4和R 6中的至少一个为C 1-3烷基以外的基团。

    Whitening Agent And Skin External Preparation
    8.
    发明申请
    Whitening Agent And Skin External Preparation 审中-公开
    美白剂和皮肤外用剂

    公开(公告)号：US20100324096A1

    公开(公告)日：2010-12-23

    申请号：US12866472

    申请日：2009-02-06

    申请人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    发明人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    IPC分类号： A61K8/49 ,  C07D277/18 ,  C07D417/12 ,  A61Q19/02

    CPC分类号： A61K31/4439 ,  A61K8/4946 ,  A61K31/506 ,  A61Q19/02

    摘要： The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein A is C1-6 alkyl, C5-6 cycloalkyl, benzyl, benzylcarbonyl, benzoyl, phenyl, pyridyl or pyrimidyl; Ra is H, C1-6 alkyl, or C2-6 alkenyl; “” represents a single bond or a double bond wherein n=1 or 2; Y is S or O; and R3 and R4 are each independently H, C1-6 alkyl, hydroxy-C1-6 alkyl, C2-7 acyl, phenyl, pyridyl, pyrimidyl, etc.;with the proviso that at least one R3 is a group other than C1-3 alkyl in the case where: the hetero ring containing Y is a thiazoline ring; R4═Ra═H; X1═X2═CH; and either p =0 or R5═C1-6 alkyl.

    摘要翻译： 本发明提供对黑素生成具有优异抑制作用并可用作增白剂的化合物和含有该化合物的皮肤外用制剂。 本发明的增白剂作为活性成分，含有式（1）表示的杂环化合物或其药理学上可接受的盐：其中A为C1-6烷基，C5-6环烷基，苄基，苄基羰基，苯甲酰基，苯基 ，吡啶基或嘧啶基; R a是H，C 1-6烷基或C 2-6烯基; “”表示单键或双键，其中n = 1或2; Y为S或O; 并且R 3和R 4各自独立地为H，C 1-6烷基，羟基-C 1-6烷基，C 2-7酰基，苯基，吡啶基，嘧啶基等;条件是至少一个R 3是除C1- 3烷基，其中：含有Y的杂环是噻唑啉环; R4 = R = X1 = X2 = CH; 和p = 0或R5 = C1-6烷基。

    Whitening Agent And Skin External Preparation
    10.
    发明申请
    Whitening Agent And Skin External Preparation 有权
    美白剂和皮肤外用剂

    公开(公告)号：US20120134944A1

    公开(公告)日：2012-05-31

    申请号：US13367577

    申请日：2012-02-07

    申请人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    发明人： Naoto Hanyu ,  Tomoko Saito ,  Takako Shibata ,  Kiyoshi Sato ,  Kimihiro Ogino

    IPC分类号： A61K8/49 ,  A61Q19/02

    CPC分类号： A61K31/4439 ,  A61K8/4946 ,  A61K31/506 ,  A61Q19/02

    摘要： The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a heterocyclic compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein R1, R2, and R2′ are each independently C1-3 alkyl; Y is S or O; and p is an integer of 0 to 3, wherein when p is 2 or 3, R1 may be the same or different.

    摘要翻译： 本发明提供对黑素生成具有优异抑制作用并可用作增白剂的化合物和含有该化合物的皮肤外用制剂。 本发明的增白剂作为活性成分，含有式（1）表示的杂环化合物或其药理学上可接受的盐：其中R1，R2和R2'各自独立地为C1-3烷基; Y为S或O; p为0〜3的整数，p为2或3时，R 1可以相同或不同。