公开(公告)号：US5439919A

公开(公告)日：1995-08-08

申请号：US93854

申请日：1993-07-20

申请人： Hiroyuki Miyachi ,  Mitsuru Segawa ,  Emiko Tagami ,  Hideo Okubo

发明人： Hiroyuki Miyachi ,  Mitsuru Segawa ,  Emiko Tagami ,  Hideo Okubo

IPC分类号： A61K31/16 ,  A61P13/02 ,  A61P15/00 ,  C07C231/12 ,  C07C237/00 ,  C07C237/20 ,  C07D295/12 ,  C07D295/13 ,  C07D295/185 ,  C07C233/00 ,  A01N43/40 ,  C07D211/30

CPC分类号： C07D295/185 ,  C07C237/20 ,  C07D295/13 ,  C07C2101/02 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2102/42 ,  C07C2103/74

摘要： Arylglycinamide derivatives represented by a general formula (1) ##STR1## (wherein Ar denotes a phenyl group which may have 1 to 3 substituents or naphthyl group which may have 1 to 3 substituents, R.sub.1 and R.sub.4 denote identically or differently hydrogen atoms or lower alkyl groups with 1 to 3 carbon atoms, R.sub.2 denotes a lower alkyl group with 1 to 6 carbon atoms, cycloalkyl group with 3 to 6 carbon atoms, lower alkyl group with 1 to 4 carbon atoms which may have a phenyl group which may have 1 to 3 substituents, norbornyl group, adamantyl group or phenyl group which may have 1 to 3 substituents, R.sub.3 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.2, R.sub.5 denotes a lower alkyl group with 1 to 6 carbon atoms or cycloalkyl group with 5 or 6 carbon atoms, R.sub.6 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.5, and m denotes 2 or 3), and their salts, which function as effective therapeutic drugs for the dysurias such as urinary incontinence and pollakiuria, and the preparative processes therefor are presented.

摘要翻译： 由通式（1）表示的芳基酰胺基酰胺衍生物（1）（其中Ar表示可具有1〜3个取代基的苯基或可具有1〜3个取代基的萘基，R 1和R 4表示相同或不同的氢原子 或具有1至3个碳原子的低级烷基，R 2表示具有1至6个碳原子的低级烷基，具有3至6个碳原子的环烷基，具有1至4个碳原子的低级烷基，其可以具有可以具有苯基的 具有1〜3个取代基，降冰片基，金刚烷基或可具有1〜3个取代基的苯基，R 3表示氢原子或碳原子数1〜6的低级烷基，或者可以与R2，R5， 表示碳原子数1〜6的低级烷基或碳原子数为5〜6的环烷基，R6表示氢原子或碳原子数1〜6的低级烷基，也可以与R5一起形成亚烷基的环，m表示 表示2或3），和 它们的盐作为排尿困难如尿失禁和尿频等有效的治疗药物及其制备方法。