公开(公告)号：US5439919A

公开(公告)日：1995-08-08

申请号：US93854

申请日：1993-07-20

申请人： Hiroyuki Miyachi ,  Mitsuru Segawa ,  Emiko Tagami ,  Hideo Okubo

发明人： Hiroyuki Miyachi ,  Mitsuru Segawa ,  Emiko Tagami ,  Hideo Okubo

IPC分类号： A61K31/16 ,  A61P13/02 ,  A61P15/00 ,  C07C231/12 ,  C07C237/00 ,  C07C237/20 ,  C07D295/12 ,  C07D295/13 ,  C07D295/185 ,  C07C233/00 ,  A01N43/40 ,  C07D211/30

CPC分类号： C07D295/185 ,  C07C237/20 ,  C07D295/13 ,  C07C2101/02 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2102/42 ,  C07C2103/74

摘要： Arylglycinamide derivatives represented by a general formula (1) ##STR1## (wherein Ar denotes a phenyl group which may have 1 to 3 substituents or naphthyl group which may have 1 to 3 substituents, R.sub.1 and R.sub.4 denote identically or differently hydrogen atoms or lower alkyl groups with 1 to 3 carbon atoms, R.sub.2 denotes a lower alkyl group with 1 to 6 carbon atoms, cycloalkyl group with 3 to 6 carbon atoms, lower alkyl group with 1 to 4 carbon atoms which may have a phenyl group which may have 1 to 3 substituents, norbornyl group, adamantyl group or phenyl group which may have 1 to 3 substituents, R.sub.3 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.2, R.sub.5 denotes a lower alkyl group with 1 to 6 carbon atoms or cycloalkyl group with 5 or 6 carbon atoms, R.sub.6 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.5, and m denotes 2 or 3), and their salts, which function as effective therapeutic drugs for the dysurias such as urinary incontinence and pollakiuria, and the preparative processes therefor are presented.

摘要翻译： 由通式（1）表示的芳基酰胺基酰胺衍生物（1）（其中Ar表示可具有1〜3个取代基的苯基或可具有1〜3个取代基的萘基，R 1和R 4表示相同或不同的氢原子 或具有1至3个碳原子的低级烷基，R 2表示具有1至6个碳原子的低级烷基，具有3至6个碳原子的环烷基，具有1至4个碳原子的低级烷基，其可以具有可以具有苯基的 具有1〜3个取代基，降冰片基，金刚烷基或可具有1〜3个取代基的苯基，R 3表示氢原子或碳原子数1〜6的低级烷基，或者可以与R2，R5， 表示碳原子数1〜6的低级烷基或碳原子数为5〜6的环烷基，R6表示氢原子或碳原子数1〜6的低级烷基，也可以与R5一起形成亚烷基的环，m表示 表示2或3），和 它们的盐作为排尿困难如尿失禁和尿频等有效的治疗药物及其制备方法。

公开(公告)号：US6103747A

公开(公告)日：2000-08-15

申请号：US313979

申请日：1999-05-19

申请人： Hiroyuki Miyachi ,  Kei Okazaki ,  Hiromi Kiyota ,  Mitsuru Segawa

发明人： Hiroyuki Miyachi ,  Kei Okazaki ,  Hiromi Kiyota ,  Mitsuru Segawa

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61P1/00 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07D233/54 ,  C07D233/60 ,  C07D233/61 ,  C07D235/06 ,  C07D235/08 ,  C07D409/06 ,  C07D409/14 ,  C07D521/00

CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D249/08

摘要： The invention relates to the imidazole derivatives as selective antagonistic substances against muscarinic acetylcholine and provides imidazole derivatives represented by a general formula (1) or (2) ##STR1## [wherein R.sub.1 is a phenyl group which may have substituent or thienyl group, R.sub.2 is a cyano group, a carboxyl group, CONR.sub.7 R.sub.8 group (wherein R.sub.7 and R.sub.8 each independently represent hydrogen atom or lower alkyl group, or R.sub.7 and R.sub.8 may form a ring by alkylene chain which may contain hetero atom) or COOR.sub.9 group (wherein R.sub.9 is a lower alkyl group), R.sub.3 is a hydrogen atom or lower alkyl group, R.sub.4, R.sub.5 and R.sub.6 each independently represent hydrogen atom, lower alkyl group which may have substituent or cycloalkyl groups, or may form a condensed ring at the positions of R.sub.5 and R.sub.6 with benzene ring, R.sub.10 is a lower alkyl group or an aralkyl group which may have substituent, m is an integer from 1 to 6, and z is a halogen atom].

摘要翻译： 本发明涉及咪唑衍生物作为针对毒蕈碱性乙酰胆碱的选择性拮抗物质，并提供由通式（1）或（2）表示的咪唑衍生物[其中R 1为可具有取代基的苯基或噻吩基，R 2为氰基 ，羧基，CONR7R8基（其中R7和R8各自独立地表示氢原子或低级烷基，或R7和R8可以通过可含有杂原子的亚烷基链形成环）或COOR9基团（其中R9是低级烷基 ），R 3为氢原子或低级烷基，R 4，R 5和R 6各自独立地表示氢原子，可具有取代基的低级烷基或环烷基，或者可以在R5和R6的位置与苯环形成稠环 R 10为低级烷基或可具有取代基的芳烷基，m为1〜6的整数，z为卤素原子]。

公开(公告)号：US5932607A

公开(公告)日：1999-08-03

申请号：US652551

申请日：1996-06-10

申请人： Hiroyuki Miyachi ,  Kei Okazaki ,  Hiromi Kiyota ,  Mitsuru Segawa

发明人： Hiroyuki Miyachi ,  Kei Okazaki ,  Hiromi Kiyota ,  Mitsuru Segawa

IPC分类号： A61K31/415 ,  A61K31/4184 ,  A61P1/00 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07D233/54 ,  C07D233/60 ,  C07D233/61 ,  C07D235/06 ,  C07D235/08 ,  C07D409/06 ,  C07D409/14 ,  C07D521/00

CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/08 ,  C07D249/08

摘要： The invention relates to the imidazole derivatives as selective antagonistic substances against muscarinic acetylcholine and provides imidazole derivatives represented by a general formula (1) or (2) ##STR1## �wherein R.sub.1 is a phenyl group which may have substituent or thienyl group, R.sub.2 is a cyano group, a carboxy group, CONR.sub.7 R.sub.8 group (wherein R.sub.7 and R.sub.8 each independently represent hydrogen atom or lower alkyl group, or R.sub.7 and R.sub.8 may form a ring by alkylene chain which may contain hetero atom) or COOR.sub.9 group (wherein R.sub.9 is a lower alkyl group), R.sub.3 is a hydrogen atom or lower alkyl group, R.sub.4, R.sub.5 and R.sub.6 each independently represent hydrogen atom, lower alkyl group which may have substituent or cycloalkyl groups, or may form a condensed ring at the positions of R.sub.5 and R.sub.6 with benzene ring, R.sub.10 is a lower alkyl group or aralkyl group which may have substituent, m is an integer from 1 to 6, and Z is a halogen atom!.

摘要翻译： PCT No.PCT / JP94 / 02021 Sec。 371日期1996年6月10日 102（e）1996年6月10日PCT 1994年12月1日PCT PCT。 WO95 / 15951 PCT出版物 日期：1995年6月15日本发明涉及咪唑衍生物作为针对毒蕈碱性乙酰胆碱的选择性拮抗物质，并提供由通式（1）或（2）表示的咪唑衍生物[其中R1为可具有取代基的苯基或噻吩基， R2是氰基，羧基，CONR7R8基（其中R7和R8各自独立地表示氢原子或低级烷基，或R7和R8可以通过可含有杂原子的亚烷基链形成环）或COOR9基团（其中R9 是低级烷基），R 3是氢原子或低级烷基，R 4，R 5和R 6各自独立地表示氢原子，可以具有取代基的低级烷基或环烷基，或者可以在R 5的位置上形成稠环 R6为苯环，R10为可具有取代基的低级烷基或芳烷基，m为1〜6的整数，Z为卤素原子]。

公开(公告)号：US07176204B2

公开(公告)日：2007-02-13

申请号：US10433153

申请日：2001-12-04

申请人： Hiroyuki Miyachi ,  Kouji Murakami

发明人： Hiroyuki Miyachi ,  Kouji Murakami

IPC分类号： A61K31/50 ,  A61K31/497 ,  C07D211/72 ,  C07D213/72

CPC分类号： C07D213/40 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/50 ,  C07D213/64 ,  C07D213/73 ,  C07D237/14 ,  C07D401/12

摘要： Novel substituted carboxylic acid derivatives which bind as ligands to human peroxisome proliferator activated receptor (PPAR) to activate the receptor and thereby exhibit potent effects of decreasing neutral fat, cholesterol, and blood sugar; and a processes for preparing the derivatives. Specifically, substituted carboxylic acid derivatives represented by general formula (1), and pharmaceutically acceptable salts and hydrates of the derivatives, and a processes for preparing the derivatives, the salts, or the hydrates

摘要翻译： 新型取代的羧酸衍生物，其结合人类过氧化物酶体增殖物激活受体（PPAR）的配体以激活受体，从而表现出降低中性脂肪，胆固醇和血糖的有效作用; 以及制备衍生物的方法。 具体地，由通式（1）表示的取代的羧酸衍生物及其衍生物的药学上可接受的盐和水合物及其衍生物，盐或水合物的制备方法

公开(公告)号：US08611456B2

公开(公告)日：2013-12-17

申请号：US13071186

申请日：2011-03-24

申请人： Takao Hashimoto ,  Hiroyuki Miyachi

发明人： Takao Hashimoto ,  Hiroyuki Miyachi

IPC分类号： H04B15/00

CPC分类号： H04L25/0266 ,  H04L25/028 ,  H04L25/0292 ,  H04L25/493

摘要： A transmission unit includes a transmission pulse signal generating circuit which generates a transmission pulse signal having pulses corresponding to a plurality of clock signals generated in a clock signal generating circuit, existing between a first pulse and a second pulse which are generated in an edge pulse generating circuit. A receiving unit is configured to decode a received pulse signal based on the transmission pulse signal received from the transmission unit via an isolated communication unit, as a signal that transitions from a first level to a second level when an initial pulse of the received pulse signal is detected and that transitions from the second level to the first level when a subsequent pulse is not detected within a predetermined first time period from when a most recent pulse of the received pulse signal is detected.

摘要翻译： 发送单元包括：发送脉冲信号发生电路，其生成具有对应于在时钟信号发生电路中产生的多个时钟信号的脉冲的发送脉冲信号，存在于在边缘脉冲产生中产生的第一脉冲和第二脉冲之间 电路。 接收单元被配置为当接收的脉冲信号的初始脉冲作为从第一电平转换到第二电平的信号时，基于从发送单元经由隔离通信单元接收的发送脉冲信号来解码所接收的脉冲信号 并且当从接收到的脉冲信号的最近的脉冲被检测到的预定的第一时间段内没有检测到后续脉冲时，从第二电平转换到第一电平。

公开(公告)号：US08410826B2

公开(公告)日：2013-04-02

申请号：US13074937

申请日：2011-03-29

申请人： Masaaki Koto ,  Naoyuki Nakamura ,  Hiroyuki Miyachi

发明人： Masaaki Koto ,  Naoyuki Nakamura ,  Hiroyuki Miyachi

IPC分类号： H03B1/00 ,  H03K3/00

CPC分类号： G01R19/0092 ,  G01R31/40

摘要： A load drive circuit with a current bidirectional detecting function includes: a current bidirectional switch connected between a first wire and a second wire and through which a first forward current flows in a direction from the first wire to the second wire and a first backward current flows in a direction from the second wire to the first wire; a forward current detecting switch connected to the first wire and into which a second forward current correlated to the first forward current flowing through the current bidirectional switch flows; a backward current detecting switch connected to the second wire and into which a second backward current correlated to the first backward current flowing through the current bidirectional switch flows.

摘要翻译： 具有电流双向检测功能的负载驱动电路包括：连接在第一线和第二线之间的电流双向开关，第一正向电流从第一线到第二线的方向流动，并且第一反向电流流过 在从第二线到第一线的方向上; 连接到第一导线的正向电流检测开关，与流过当前双向开关的第一正向电流相关的第二正向电流流入该正向电流检测开关; 连接到第二导线的反向电流检测开关，并且与流过当前双向开关的第一反向电流相关的第二反向电流流向该电流检测开关。

公开(公告)号：US20110304360A1

公开(公告)日：2011-12-15

申请号：US13158961

申请日：2011-06-13

申请人： Naoyuki NAKAMURA ,  Hiroyuki Miyachi

发明人： Naoyuki NAKAMURA ,  Hiroyuki Miyachi

IPC分类号： H02M7/217

CPC分类号： H02M1/083 ,  H02M2001/0048 ,  H03K17/302 ,  H03K2017/307 ,  Y02B70/1491

摘要： The present invention introduces a diode circuit which achieves ideal diode characteristics which observe an enough reverse breakdown voltage, and whose forward voltage is nearly 0 V. An active diode has an anode terminal and a cathode terminal. The active diode includes a transistor which has a gate terminal, a drain terminal connected to one of the anode terminal and the cathode terminal, and a source terminal connected to the other one of the anode terminal or the cathode terminal; and a gate voltage generating circuit which delivers a gate voltage to the gate terminal, the gate voltage being adjusted to be equal to a threshold voltage of the transistor.

摘要翻译： 本发明引入二极管电路，其实现理想的二极管特性，其观察到足够的反向击穿电压，并且其正向电压接近0V。有源二极管具有阳极端子和阴极端子。 有源二极管包括晶体管，其具有栅极端子，漏极端子连接到阳极端子和阴极端子中的一个，以及连接到阳极端子或阴极端子中的另一个的源极端子; 以及栅极电压产生电路，其向栅极端子输送栅极电压，栅极电压被调节为等于晶体管的阈值电压。

公开(公告)号：US06734199B1

公开(公告)日：2004-05-11

申请号：US10049904

申请日：2002-02-20

申请人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

发明人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

IPC分类号： A61K31426

CPC分类号： C07D277/34

摘要： The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein A denotes a phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and a process for preparing them.

摘要翻译： 本发明提供新的取代的苄基噻唑烷-2,4-二酮衍生物，其增加受体作为人过氧化物酶体增殖物激活受体（PPAR）的配体的反式激活作用，并显示出降血糖作用和降脂作用， 本发明涉及由通式（1）表示的取代的苄基噻唑烷-2,4-二酮衍生物[其中A表示未取代或可具有取代基的苯基，未取代或可具有取代基的苯氧基或 未取代或可具有取代基的苄氧基，其药学上可接受的盐，它们的水合物及其制备方法。

公开(公告)号：US5777967A

公开(公告)日：1998-07-07

申请号：US628298

申请日：1996-04-05

申请人： Hiromichi Ishibashi ,  Toshiyuki Shimada ,  Yasuaki Edahiro ,  Mitsurou Moriya ,  Ryusuke Horibe ,  Hiroyuki Miyachi

发明人： Hiromichi Ishibashi ,  Toshiyuki Shimada ,  Yasuaki Edahiro ,  Mitsurou Moriya ,  Ryusuke Horibe ,  Hiroyuki Miyachi

IPC分类号： G11B7/0037 ,  G11B7/005 ,  G11B20/10 ,  G11B27/36 ,  G11B7/00

CPC分类号： G11B20/10009 ,  G11B27/36 ,  G11B7/00375 ,  G11B7/005

摘要： A phase error between an information signal including a reference signal that can be detected asynchronously and a synchronized signal that is synchronously produced from the information signal is detected, and a signal in response to an absolute value of the phase error is produced. Further, a defect detecting signal is produced in response to the absolute value of the phase error. Therefore, whether a pulse signal exceeding a maximum value of the pulse width of the information signal, that is, a pulse signal exceeding the pulse width of the reference signal, is detected or not, it is possible to detect that the signal reproduction enters a defect region immediately after the entry. Accordingly, a defect with noise or a track jumping can be detected rapidly. Furthermore, an information transition interval of the information signal is measured for a prescribed period of time, and the defect detecting signal is terminated in response to a measured value of a time length of the reference signal that is detected in the prescribed period of time, in other words, the passing of the signal reproduction through the defect region is detected with reference to the synchronization of the reference signal. Therefore, pseudo locking of a PLL is avoided when it is operated again, and the PLL can be accurately re-locked.

摘要翻译： 检测包括可以异步检测的参考信号的信息信号与从信息信号同步产生的同步信号之间的相位误差，并且产生响应于相位误差的绝对值的信号。 此外，响应于相位误差的绝对值产生缺陷检测信号。 因此，检测到是否检测到超过信息信号的脉冲宽度的最大值的脉冲信号，即超过参考信号的脉冲宽度的脉冲信号，则可以检测到信号再现进入 缺陷区域。 因此，可以快速地检测到具有噪声或轨迹跳跃的缺陷。 此外，信息信号的信息转换间隔在规定时间内被测量，并且响应于在规定时间段内检测到的参考信号的时间长度的测量值而终止缺陷检测信号， 换句话说，参考参考信号的同步来检测通过缺陷区域的信号再现的通过。 因此，当再次操作PLL时，可以避免PLL的伪锁定，并且可以准确地重新锁定PLL。

公开(公告)号：US20110235737A1

公开(公告)日：2011-09-29

申请号：US13071186

申请日：2011-03-24

申请人： Takao HASHIMOTO ,  Hiroyuki Miyachi

发明人： Takao HASHIMOTO ,  Hiroyuki Miyachi

IPC分类号： H04B15/00

CPC分类号： H04L25/0266 ,  H04L25/028 ,  H04L25/0292 ,  H04L25/493

摘要： A transmission unit includes a transmission pulse signal generating circuit which generates a transmission pulse signal having pulses corresponding to a plurality of clock signals generated in a clock signal generating circuit, existing between a first pulse and a second pulse which are generated in an edge pulse generating circuit. A receiving unit is configured to decode a received pulse signal based on the transmission pulse signal received from the transmission unit via an isolated communication unit, as a signal that transitions from a first level to a second level when an initial pulse of the received pulse signal is detected and that transitions from the second level to the first level when a subsequent pulse is not detected within a predetermined first time period from when a most recent pulse of the received pulse signal is detected.

摘要翻译： 发送单元包括：发送脉冲信号发生电路，其生成具有对应于在时钟信号发生电路中产生的多个时钟信号的脉冲的发送脉冲信号，存在于在边缘脉冲产生中产生的第一脉冲和第二脉冲之间 电路。 接收单元被配置为当接收的脉冲信号的初始脉冲作为从第一电平转换到第二电平的信号时，基于从发送单元经由隔离通信单元接收的发送脉冲信号来解码所接收的脉冲信号 并且当从接收到的脉冲信号的最近的脉冲被检测到的预定的第一时间段内没有检测到后续脉冲时，从第二电平转换到第一电平。