公开(公告)号：US07176204B2

公开(公告)日：2007-02-13

申请号：US10433153

申请日：2001-12-04

申请人： Hiroyuki Miyachi ,  Kouji Murakami

发明人： Hiroyuki Miyachi ,  Kouji Murakami

IPC分类号： A61K31/50 ,  A61K31/497 ,  C07D211/72 ,  C07D213/72

CPC分类号： C07D213/40 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/50 ,  C07D213/64 ,  C07D213/73 ,  C07D237/14 ,  C07D401/12

摘要： Novel substituted carboxylic acid derivatives which bind as ligands to human peroxisome proliferator activated receptor (PPAR) to activate the receptor and thereby exhibit potent effects of decreasing neutral fat, cholesterol, and blood sugar; and a processes for preparing the derivatives. Specifically, substituted carboxylic acid derivatives represented by general formula (1), and pharmaceutically acceptable salts and hydrates of the derivatives, and a processes for preparing the derivatives, the salts, or the hydrates

摘要翻译： 新型取代的羧酸衍生物，其结合人类过氧化物酶体增殖物激活受体（PPAR）的配体以激活受体，从而表现出降低中性脂肪，胆固醇和血糖的有效作用; 以及制备衍生物的方法。 具体地，由通式（1）表示的取代的羧酸衍生物及其衍生物的药学上可接受的盐和水合物及其衍生物，盐或水合物的制备方法

公开(公告)号：US5439919A

公开(公告)日：1995-08-08

申请号：US93854

申请日：1993-07-20

申请人： Hiroyuki Miyachi ,  Mitsuru Segawa ,  Emiko Tagami ,  Hideo Okubo

发明人： Hiroyuki Miyachi ,  Mitsuru Segawa ,  Emiko Tagami ,  Hideo Okubo

IPC分类号： A61K31/16 ,  A61P13/02 ,  A61P15/00 ,  C07C231/12 ,  C07C237/00 ,  C07C237/20 ,  C07D295/12 ,  C07D295/13 ,  C07D295/185 ,  C07C233/00 ,  A01N43/40 ,  C07D211/30

CPC分类号： C07D295/185 ,  C07C237/20 ,  C07D295/13 ,  C07C2101/02 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2102/42 ,  C07C2103/74

摘要： Arylglycinamide derivatives represented by a general formula (1) ##STR1## (wherein Ar denotes a phenyl group which may have 1 to 3 substituents or naphthyl group which may have 1 to 3 substituents, R.sub.1 and R.sub.4 denote identically or differently hydrogen atoms or lower alkyl groups with 1 to 3 carbon atoms, R.sub.2 denotes a lower alkyl group with 1 to 6 carbon atoms, cycloalkyl group with 3 to 6 carbon atoms, lower alkyl group with 1 to 4 carbon atoms which may have a phenyl group which may have 1 to 3 substituents, norbornyl group, adamantyl group or phenyl group which may have 1 to 3 substituents, R.sub.3 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.2, R.sub.5 denotes a lower alkyl group with 1 to 6 carbon atoms or cycloalkyl group with 5 or 6 carbon atoms, R.sub.6 denotes a hydrogen atom or lower alkyl group with 1 to 6 carbon atoms or it may form a ring constituting alkylene together with R.sub.5, and m denotes 2 or 3), and their salts, which function as effective therapeutic drugs for the dysurias such as urinary incontinence and pollakiuria, and the preparative processes therefor are presented.

摘要翻译： 由通式（1）表示的芳基酰胺基酰胺衍生物（1）（其中Ar表示可具有1〜3个取代基的苯基或可具有1〜3个取代基的萘基，R 1和R 4表示相同或不同的氢原子 或具有1至3个碳原子的低级烷基，R 2表示具有1至6个碳原子的低级烷基，具有3至6个碳原子的环烷基，具有1至4个碳原子的低级烷基，其可以具有可以具有苯基的 具有1〜3个取代基，降冰片基，金刚烷基或可具有1〜3个取代基的苯基，R 3表示氢原子或碳原子数1〜6的低级烷基，或者可以与R2，R5， 表示碳原子数1〜6的低级烷基或碳原子数为5〜6的环烷基，R6表示氢原子或碳原子数1〜6的低级烷基，也可以与R5一起形成亚烷基的环，m表示 表示2或3），和 它们的盐作为排尿困难如尿失禁和尿频等有效的治疗药物及其制备方法。

公开(公告)号：US20110248748A1

公开(公告)日：2011-10-13

申请号：US13074937

申请日：2011-03-29

申请人： Masaaki Koto ,  Naoyuki Nakamura ,  Hiroyuki Miyachi

发明人： Masaaki Koto ,  Naoyuki Nakamura ,  Hiroyuki Miyachi

IPC分类号： H03K3/00

CPC分类号： G01R19/0092 ,  G01R31/40

摘要： A load drive circuit with a current bidirectional detecting function includes: a current bidirectional switch connected between a first wire and a second wire and through which a first forward current flows in a direction from the first wire to the second wire and a first backward current flows in a direction from the second wire to the first wire; a forward current detecting switch connected to the first wire and into which a second forward current correlated to the first forward current flowing through the current bidirectional switch flows; a backward current detecting switch connected to the second wire and into which a second backward current correlated to the first backward current flowing through the current bidirectional switch flows.

摘要翻译： 具有电流双向检测功能的负载驱动电路包括：连接在第一线和第二线之间的电流双向开关，第一正向电流从第一线到第二线的方向流动，并且第一反向电流流过 在从第二线到第一线的方向上; 连接到第一导线的正向电流检测开关，与流过当前双向开关的第一正向电流相关的第二正向电流流入该正向电流检测开关; 连接到第二导线的反向电流检测开关，并且与流过当前双向开关的第一反向电流相关的第二反向电流流向该电流检测开关。

公开(公告)号：US06506797B1

公开(公告)日：2003-01-14

申请号：US10009175

申请日：2001-12-10

申请人： Masahiro Nomura ,  Yukie Takahashi ,  Takahiro Tanase ,  Hiroyuki Miyachi ,  Masaki Tsunoda ,  Tomohiro Ide ,  Koji Murakami

发明人： Masahiro Nomura ,  Yukie Takahashi ,  Takahiro Tanase ,  Hiroyuki Miyachi ,  Masaki Tsunoda ,  Tomohiro Ide ,  Koji Murakami

IPC分类号： A01N3712

CPC分类号： C07D263/26 ,  A61K31/195 ,  C07C235/60 ,  C07C323/60

摘要： The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor &agr; (PPAR&agr;), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride). It relates to a substituted phenylpropanoic acid derivatives represented by a general formula (1), their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.

摘要翻译： 本发明提供新的取代苯丙酸衍生物，其通过与作为人过氧化物酶体增生物激活受体α（PPARα）的配体的受体结合而活化，并且对血液中的脂质（胆固醇和甘油三酸酯）表现出有效的降低作用。涉及取代的苯丙酸 由通式（1）表示的衍生物，其药学上可接受的盐及其水合物及其制备方法。

公开(公告)号：US6071950A

公开(公告)日：2000-06-06

申请号：US308661

申请日：1999-06-02

申请人： Hiroyuki Miyachi ,  Masato Hoshino ,  Naoki Ando ,  Fumiyoshi Kobayashi

发明人： Hiroyuki Miyachi ,  Masato Hoshino ,  Naoki Ando ,  Fumiyoshi Kobayashi

IPC分类号： C07D207/12 ,  A61K31/40 ,  C07D207/00

CPC分类号： C07D207/12

摘要： Novel N-substituted pyrrolidine derivatives having a highly selective and potent antagonism against smooth muscle muscarine receptors and being useful for the treatment of irritable bowel syndrome and the like, characterized by being represented by general formula (1) wherein R represents a hydrogen atom, a halogen atom, or a lower alkoxy group and a process for preparing the same.

摘要翻译： PCT No.PCT / JP97 / 04306 Sec。 371日期1999年6月2日 102（e）1999年6月2日PCT 1997年11月26日PCT公布。 公开号WO98 / 24431 日期1998年6月11日具有对平滑肌毒蕈碱受体具有高选择性和有效拮抗作用的新型N-取代吡咯烷衍生物，可用于治疗肠易激综合征等，其特征在于通式（1）表示，其中R表示 氢原子，卤原子或低级烷氧基及其制备方法。

公开(公告)号：US5666341A

公开(公告)日：1997-09-09

申请号：US710266

申请日：1996-09-13

申请人： Ryusuke Horibe ,  Toshiyuki Shimada ,  Hiromiti Ishibashi ,  Hiroyuki Miyachi

发明人： Ryusuke Horibe ,  Toshiyuki Shimada ,  Hiromiti Ishibashi ,  Hiroyuki Miyachi

IPC分类号： G11B19/12 ,  G11B20/14 ,  G11B27/30 ,  H03L7/081 ,  H03L7/089 ,  H03L7/113 ,  G11B5/09

CPC分类号： H03L7/081 ,  G11B19/12 ,  G11B20/1403 ,  G11B27/3027 ,  H03L7/0891 ,  H03L7/113

摘要： A reproduced signal is digitized so as to count a time interval of a specified pattern simultaneously with the count of a clock period of a phase lock loop circuit. A phase lock loop clock frequency is subjected to a feedback control based on the information indicated the difference between the time interval and the clock period. In this manner, a frequency loop performs a feedback operation so that a frequency of the reproduced signal falls within a capture range of a phase lock-in, thereby increasing the speed of phase lock-in.

摘要翻译： 再现信号被数字化，以便与锁相环电路的时钟周期的计数同时对特定模式的时间间隔进行计数。 基于指示时间间隔和时钟周期之间的差异的信息对锁相环时钟频率进行反馈控制。 以这种方式，频率环路执行反馈操作，使得再现信号的频率落入相位锁定的捕获范围内，从而增加相位锁定的速度。

公开(公告)号：US5063706A

公开(公告)日：1991-11-12

申请号：US637555

申请日：1991-01-04

申请人： Seietsu Aki ,  Takaaki Ito ,  Yasuo Abe ,  Ichiro Inoue ,  Hiroyuki Miyachi

发明人： Seietsu Aki ,  Takaaki Ito ,  Yasuo Abe ,  Ichiro Inoue ,  Hiroyuki Miyachi

IPC分类号： A01M13/00 ,  A01G9/18 ,  A01M1/20 ,  A01M1/24 ,  A01M7/00 ,  A01M17/00 ,  A61L2/16

CPC分类号： A01M17/008 ,  A01G9/18 ,  A01M1/2038 ,  A01M1/245 ,  A01M2200/011

摘要： A device for exterminating pests having a cylinder filled with carbon dioxide in which (a) pesticide(s) is(are) dissolved, piping coupled to the cylinder, and a plurality of capillary nozzles affixed to the piping, and a method of exterminating pests employed this device. The capillary nozzles are designed such that, considering adjacent capillary nozzles, the ratio of the nozzle exit area of the capillary nozzle close to the cylinder to the nozzle exit area of the capillary nozzle remote from the cylinder is set between 1:1.3 and 1:1.8. As a result, numerous independent enclosed spaces can be sprayed with little labor and in a short time by means of a small number of devices.

摘要翻译： 一种用于灭虫害虫的装置，其具有充满二氧化碳的气瓶，其中（a）溶解有农药，与气缸连接的管道和固定在管道上的多个毛细喷嘴，以及灭虫害虫的方法 使用这个设备。 毛细管喷嘴被设计成使得考虑到相邻的毛细管喷嘴，毛细管喷嘴的喷嘴出口面积相对于气缸与喷嘴远离气缸的喷嘴出口区域的比率设定在1：1.3和1： 1.8。 因此，许多独立的封闭空间可以用少量的装置在很短的时间内被喷洒。

公开(公告)号：US08410826B2

公开(公告)日：2013-04-02

申请号：US13074937

申请日：2011-03-29

申请人： Masaaki Koto ,  Naoyuki Nakamura ,  Hiroyuki Miyachi

发明人： Masaaki Koto ,  Naoyuki Nakamura ,  Hiroyuki Miyachi

IPC分类号： H03B1/00 ,  H03K3/00

CPC分类号： G01R19/0092 ,  G01R31/40

摘要： A load drive circuit with a current bidirectional detecting function includes: a current bidirectional switch connected between a first wire and a second wire and through which a first forward current flows in a direction from the first wire to the second wire and a first backward current flows in a direction from the second wire to the first wire; a forward current detecting switch connected to the first wire and into which a second forward current correlated to the first forward current flowing through the current bidirectional switch flows; a backward current detecting switch connected to the second wire and into which a second backward current correlated to the first backward current flowing through the current bidirectional switch flows.

摘要翻译： 具有电流双向检测功能的负载驱动电路包括：连接在第一线和第二线之间的电流双向开关，第一正向电流从第一线到第二线的方向流动，并且第一反向电流流过 在从第二线到第一线的方向上; 连接到第一导线的正向电流检测开关，与流过当前双向开关的第一正向电流相关的第二正向电流流入该正向电流检测开关; 连接到第二导线的反向电流检测开关，并且与流过当前双向开关的第一反向电流相关的第二反向电流流向该电流检测开关。

公开(公告)号：US20110304360A1

公开(公告)日：2011-12-15

申请号：US13158961

申请日：2011-06-13

申请人： Naoyuki NAKAMURA ,  Hiroyuki Miyachi

发明人： Naoyuki NAKAMURA ,  Hiroyuki Miyachi

IPC分类号： H02M7/217

CPC分类号： H02M1/083 ,  H02M2001/0048 ,  H03K17/302 ,  H03K2017/307 ,  Y02B70/1491

摘要： The present invention introduces a diode circuit which achieves ideal diode characteristics which observe an enough reverse breakdown voltage, and whose forward voltage is nearly 0 V. An active diode has an anode terminal and a cathode terminal. The active diode includes a transistor which has a gate terminal, a drain terminal connected to one of the anode terminal and the cathode terminal, and a source terminal connected to the other one of the anode terminal or the cathode terminal; and a gate voltage generating circuit which delivers a gate voltage to the gate terminal, the gate voltage being adjusted to be equal to a threshold voltage of the transistor.

摘要翻译： 本发明引入二极管电路，其实现理想的二极管特性，其观察到足够的反向击穿电压，并且其正向电压接近0V。有源二极管具有阳极端子和阴极端子。 有源二极管包括晶体管，其具有栅极端子，漏极端子连接到阳极端子和阴极端子中的一个，以及连接到阳极端子或阴极端子中的另一个的源极端子; 以及栅极电压产生电路，其向栅极端子输送栅极电压，栅极电压被调节为等于晶体管的阈值电压。

公开(公告)号：US06734199B1

公开(公告)日：2004-05-11

申请号：US10049904

申请日：2002-02-20

申请人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

发明人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

IPC分类号： A61K31426

CPC分类号： C07D277/34

摘要： The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein A denotes a phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and a process for preparing them.

摘要翻译： 本发明提供新的取代的苄基噻唑烷-2,4-二酮衍生物，其增加受体作为人过氧化物酶体增殖物激活受体（PPAR）的配体的反式激活作用，并显示出降血糖作用和降脂作用， 本发明涉及由通式（1）表示的取代的苄基噻唑烷-2,4-二酮衍生物[其中A表示未取代或可具有取代基的苯基，未取代或可具有取代基的苯氧基或 未取代或可具有取代基的苄氧基，其药学上可接受的盐，它们的水合物及其制备方法。