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公开(公告)号:US20050239868A1
公开(公告)日:2005-10-27
申请号:US10521958
申请日:2003-07-22
申请人: Hiroyuki Shirai , Tatsuya Nakai , Masami Serizawa , Yasuo Shinoda , Toshio Inagi
发明人: Hiroyuki Shirai , Tatsuya Nakai , Masami Serizawa , Yasuo Shinoda , Toshio Inagi
IPC分类号: A61K9/06 , A61K31/405 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/38 , A61K47/44 , A61P29/00
CPC分类号: A61K9/06 , A61K9/0014 , A61K31/405 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/38 , A61K47/44
摘要: An object of the present invention is to provide an indomethacin external preparation that has an excellent use feeling and excellent absorbability and causes no phase separation into an oil layer and an aqueous layer, thus exhibiting satisfactory stability of preparation with time. Provided is an indomethacin external preparation containing: 0.1 to 3 wt % of indomethacin; 25 to 50 wt % of alcohol; 0.01 to 5 wt % of gelling agent; 5 to 30 wt % of oil component; 20 to 50 wt % of water; and 0.01 to 10 wt % of one or more components selected from the group consisting of glyceryl monostearate, sorbitan monostearate, stearyl alcohol, and polyethylene glycol monostearate.
摘要翻译: 本发明的目的是提供具有优异的使用感和优异的吸收性的吲哚美辛外用制剂,并且不会使相分离成油层和水层,从而表现出令人满意的制备时间稳定性。 本发明提供消炎痛外用制剂,含有0.1〜3重量%的吲哚美辛; 25〜50重量%的醇; 0.01〜5重量%的胶凝剂; 5〜30重量%的油成分; 20〜50重量%的水; 和0.01〜10重量%的选自单硬脂酸甘油酯,脱水山梨糖醇单硬脂酸酯,硬脂醇和聚乙二醇单硬脂酸酯的一种或多种成分。
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公开(公告)号:US07553865B2
公开(公告)日:2009-06-30
申请号:US10521958
申请日:2003-07-22
申请人: Hiroyuki Shirai , Tatsuya Nakai , Masami Serizawa , Yasuo Shinoda , Toshio Inagi
发明人: Hiroyuki Shirai , Tatsuya Nakai , Masami Serizawa , Yasuo Shinoda , Toshio Inagi
IPC分类号: A61K31/40 , A01N43/38 , C07D209/26
CPC分类号: A61K9/06 , A61K9/0014 , A61K31/405 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/32 , A61K47/38 , A61K47/44
摘要: An object of the present invention is to provide an indomethacin external preparation that has an excellent use feeling and excellent absorbability and causes no phase separation into an oil layer and an aqueous layer, thus exhibiting satisfactory stability of preparation with time. Provided is an indomethacin external preparation containing: 0.1 to 3 wt % of indomethacin; 25 to 50 wt % of alcohol; 0.01 to 5 wt % of gelling agent; 5 to 30 wt % of oil component; 20 to 50 wt % of water; and 0.01 to 10 wt % of one or more components selected from the group consisting of glyceryl monostearate, sorbitan monostearate, stearyl alcohol, and polyethylene glycol monostearate.
摘要翻译: 本发明的目的是提供具有优异的使用感和优异的吸收性的吲哚美辛外用制剂,并且不会使相分离成油层和水层,从而表现出令人满意的制备时间稳定性。 本发明提供消炎痛外用制剂,含有0.1〜3重量%的吲哚美辛; 25〜50重量%的醇; 0.01〜5重量%的胶凝剂; 5〜30重量%的油成分; 20〜50重量%的水; 和0.01〜10重量%的选自单硬脂酸甘油酯,脱水山梨糖醇单硬脂酸酯,硬脂醇和聚乙二醇单硬脂酸酯的一种或多种成分。
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