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    Process for producing 3-methyl-2-oxoindoline
    1.
    发明授权
    Process for producing 3-methyl-2-oxoindoline 失效
    3-甲基-2-氧代二氢吲哚的制备方法

    公开(公告)号：US06268512B1

    公开(公告)日：2001-07-31

    申请号：US09600019

    申请日：2000-07-11

    申请人： Hisao Kondo ,  Tetsuro Higashikawa

    发明人： Hisao Kondo ,  Tetsuro Higashikawa

    IPC分类号： C07D20712

    CPC分类号： C07D209/34

    摘要： The present invention is a process for producing 3-methyl-2-oxoindoline as defined by the following chemical formula (2), including heating of propionylphenylhydrazide as defined by the following chemical formula (1) in the presence of at least one kind of basic calcium compound, characterized in that an organic solvent withstanding at least at a temperature of 180° C. in the presence of the basic calcium compound is employed by at least an amount of equal weight to that of the propionylphenylhydrazide. With the construction mentioned above, even when the amount of calcium oxide is reduced down to as little as 15% of a conventionally used amount, at least 75% of a corresponding yield attained conventionally has been achieved. That is, not only control of the reaction and easy after treatment but also a high yield has been achieved;

    摘要翻译： 本发明是由以下化学式（2）定义的3-甲基-2-氧代二氢吲哚的制造方法，其中包括如下化学式（1）所定义的丙酰基苯基酰肼在至少一种碱性 钙化合物，其特征在于，在碱性钙化合物的存在下，至少在180℃的温度下耐受的有机溶剂的使用量至少与丙酰基苯肼的重量相同。 通过上述结构，即使氧化钙的量减少到常规使用量的少至15％，也达到了通常达到相应产率的至少75％。 也就是说，不仅控制反应，而且处理容易，而且成品率高;

    Syringe, its sealing structure and sealing method and sliding valve for syringe
    4.
    发明授权
    Syringe, its sealing structure and sealing method and sliding valve for syringe 失效

    公开(公告)号：US5851200A

    公开(公告)日：1998-12-22

    申请号：US765902

    申请日：1997-01-07

    申请人： Tetsuro Higashikawa ,  Hirokazu Suzuki

    发明人： Tetsuro Higashikawa ,  Hirokazu Suzuki

    IPC分类号： B32B27/04 ,  A61M5/00 ,  A61M5/178 ,  A61M5/24 ,  A61M5/28 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  B32B27/08 ,  B32B33/00 ,  B44C5/04 ,  B44F1/14 ,  D21H19/80 ,  D21H27/02 ,  D21H27/26 ,  E04F13/08

    CPC分类号： B44C5/0476 ,  A61M5/284 ,  A61M5/3134 ,  A61M5/31511 ,  B44C5/0492 ,  B44F1/14 ,  D21H27/26 ,  E04F13/0871 ,  A61M2005/3118 ,  A61M2005/312 ,  A61M2005/3123 ,  A61M2005/3132 ,  A61M5/002 ,  A61M5/3202

    摘要： As a sealing structure for a syringe, a waterproofing film is adhered to the surface of a cap (6), a barrel (3) and a cylinder body (2) to cover fitting areas therebetween. The film is made of synthetic resin having a melting point higher than the temperature of flowing water vapor in post sterilization. As a sliding valve for a syringe, an inclined lip (24) is continuously protruded from the outer surface of a short cylindrical body (22). At the one end of the body, an annular lip (23) is formed. The inclined lip has a recess (34) for introducing a medicine liquid. The inclined lip may be formed in plural pairs of inverted , in plural stages, in plural strips in an axial direction, or in a shape to cross to form a sea slug wall. The sliding valve can be inserted with no inclination so that stagnant of air is not produced. As a syringe, at the tip of a cylinder, a bulging portion (87) having a larger inner diameter than that of the cylinder is formed integrally to the cylinder and the inner diameter of said bulging portion is larger than the outer diameter of an elastic sliding valve so that a medicine liquid is discharged through a gap on the outside. On the bottom wall of said bulging portion, a protrusion (94) for supporting said sliding valve is formed to form a gap on the bottom. The sliding valve (90) includes a body (101) having a smaller diameter than the inner diameter of said bulging portion and a supporting member (102) having a plurality of supporting protrusions protruding in a radial direction from the center of the body, arranged equidistantly in a circumferential direction and having a lower elastic modulus than that of said body, and said supporting protrusions are brought into contact with the inner face of said bulging portion. Since the cylinder is an integral type, intrusion of flowing water vapor and vacteria is prevented.

    Syringe
    5.
    发明授权
    Syringe 失效
    注射器

    公开(公告)号：US5830193A

    公开(公告)日：1998-11-03

    申请号：US557099

    申请日：1995-12-06

    申请人： Tetsuro Higashikawa

    发明人： Tetsuro Higashikawa

    IPC分类号： A61M5/28 ,  A61M5/31 ,  A61M5/50 ,  A61M5/00

    CPC分类号： A61M5/3134 ,  A61M5/284 ,  A61M2005/1787 ,  A61M2005/3104 ,  A61M2005/312 ,  A61M2005/3123 ,  A61M2005/3132 ,  A61M5/5086

    摘要： A syringe in which one or more injectable materials are filled, comprises a cylinder or barrel in which a front partition stopper, which can be fixed or movable depending on the embodiment, and one or more intermediate partition stoppers are slidably disposed. In the simplest arrangement, a single intermediate partition stopper is disposed between the front partition stopper and a rear piston, to define first and second chambers within the cylinder in which first and second injectable materials can be respectively filled. An outer periphery of the intermediate partition stopper is provided with a plurality of circular lips between which at least one peripheral groove is defined. One of the first and second chambers is communicated with peripheral groove or grooves of the intermediate partition stopper by small passages to allow the first medicine, which is in liquid form, to enter and fill the groove or grooves and exclude air and bacteria therefrom. A transfer passage or passages are arranged in the wall of the cylinder to allow the first and second medicines to mix as the partition stopper is moved forward in response to the rear piston being forced into the cylinder.

    摘要翻译： PCT No.PCT / JP94 / 02138 Sec。 371 1995年12月6日第 102（e）日期1995年12月6日PCT 1994年12月19日PCT PCT。 公开号WO95 / 17916 日期1995年7月6日一个或多个可注射材料填充的注射器包括圆柱体或筒体，根据实施例，可以固定或移动的前分隔止动件和一个或多个中间分隔止动件可滑动地布置 。 在最简单的布置中，在前分隔止动件和后活塞之间设置单个中间分隔止动件，以限定气缸内的第一和第二腔室，第一和第二可注射材料可以分别装入其中。 中间隔挡件的外周设置有多个圆形的唇部，在其间限定有至少一个周向槽。 第一和第二腔室中的一个通过小通道与中间分隔塞的周边沟槽连通，以允许液体形式的第一药物进入并填充凹槽或凹槽，并排除空气和细菌。 传送通道或通道布置在气缸的壁中，以使得第一和第二药物随着后活塞被迫进入气缸中的分隔塞向前运动而混合。