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    Crosslinked polymide compound and use thereof
    1.
    发明申请
    Crosslinked polymide compound and use thereof 审中-公开
    交联聚酰亚胺化合物及其用途

    公开(公告)号：US20070117960A1

    公开(公告)日：2007-05-24

    申请号：US10588998

    申请日：2005-02-10

    申请人： Hisashi Kizuka ,  Hisaharu Kuboyama ,  Kunio Okumura ,  Toshio Katoh

    发明人： Hisashi Kizuka ,  Hisaharu Kuboyama ,  Kunio Okumura ,  Toshio Katoh

    IPC分类号： C08G69/08

    CPC分类号： A61K8/88 ,  A61Q19/00 ,  C08G73/10

    摘要： A polyimide compound crosslinked with a polyamine which is soluble in the specific solvent is produced by dehydration and condensation of amino acid or salt thereof and polyamine in an organic solvent under the presence of protonic acid. In the case of using a polyamine having low solubility to an organic solvent such as lysine and ornithine, the reaction rate of the polymerization can be increased by adding a polyamine in the step before or at the initial step of polymerization because water which is contained in the raw material or produced in the dehydration reaction serves as a good solvent for the polyamine.

    摘要翻译： 通过在质子酸存在下，在有机溶剂中使氨基酸或其盐与多胺进行脱水缩合而制备可溶于特定溶剂的多胺交联的聚酰亚胺化合物。 在使用对赖氨酸和鸟氨酸等有机溶剂具有低溶解性的多胺的情况下，聚合反应的速度可以通过在聚合反应初期或之前的步骤中加入多胺来提高，因为含有 在脱水反应中产生的原料或作为多胺的良溶剂。

    Production process of polysuccinimide
    2.
    发明授权
    Production process of polysuccinimide 有权
    聚琥珀酰亚胺的生产工艺

    公开(公告)号：US06657041B1

    公开(公告)日：2003-12-02

    申请号：US09868498

    申请日：2001-06-18

    申请人： Katsuhiko Machida ,  Susumu Fukawa ,  Shinji Ogawa ,  Toshio Katoh ,  Makoto Sukegawa ,  Yoshihiro Irizato

    发明人： Katsuhiko Machida ,  Susumu Fukawa ,  Shinji Ogawa ,  Toshio Katoh ,  Makoto Sukegawa ,  Yoshihiro Irizato

    IPC分类号： C08G6910

    CPC分类号： C08G73/1092 ,  C08G69/10

    摘要： A production process of high molecular weight polysuccinimide having a weight average molecular weight of 40,000 or higher is disclosed, which comprises the following steps: 1) mixing and heating aspartic acid and an acidic catalyst to produce a liquid, low molecular weight polymer mixture, 2) separating the acidic catalyst to appropriate extent from the liquid, low molecular weight polymer mixture, thereby directly changing a polymer-containing phase from a liquid phase into a solid phase to produce a solid, low molecular weight polymer mixture, and 3) conducting solid-state polymerization on the thus-obtained solid, low molecular weight polymer mixture. This process can be practiced in a simple apparatus, and is free of problems such as formation of a highly viscous phase, excessive formation of foam, and formation of a reaction mixture into coherent mass.

    摘要翻译： 公开了重均分子量为40,000以上的高分子量聚琥珀酰亚胺的生产方法，其包括以下步骤：1）将天冬氨酸和酸性催化剂混合加热以制备液体低分子量聚合物混合物2 ）将酸性催化剂从液态低分子量聚合物混合物中分离出适当的程度，由此直接将含聚合物的相从液相转变为固相以产生固体低分子量聚合物混合物，和3）导电固体 在这样得到的固体低分子量聚合物混合物上进行状态聚合。 该方法可以在简单的装置中实施，并且没有诸如高粘性相的形成，泡沫过度形成以及反应混合物形成连续质量的问题。

    Preparation of N-protected .alpha.-L-aspartyl-L-phenylalanine methyl ester
    5.
    发明授权
    Preparation of N-protected .alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
    N-保护的α-L-天冬氨酰基-L-苯丙氨酸甲酯的制备

    公开(公告)号：US5302743A

    公开(公告)日：1994-04-12

    申请号：US823538

    申请日：1992-01-21

    申请人： Toshio Katoh ,  Chojiro Higuchi ,  Takeshi Oura ,  Masanobu Ajioka ,  Akihiro Yamaguchi

    发明人： Toshio Katoh ,  Chojiro Higuchi ,  Takeshi Oura ,  Masanobu Ajioka ,  Akihiro Yamaguchi

    IPC分类号： C07K5/075 ,  C07C229/00

    CPC分类号： C07K5/0613 ,  Y02P20/55

    摘要： Disclosed is an improved process for the preparation of an N-protected .alpha.-L-aspartyl-L-phenylalanine methyl ester from an N-protected L-aspartic anhydride and L-phenylalanine methyl ester, the improvement which comprises employing the L-phenylalanine methyl ester in the form of a mineral acid salt thereof and conducting the reaction either (a) in an organic solvent and in the presence of a salt of an organic carboxylic acid, or (b) in an organic solvent comprising an organic carboxylic acid and in the presence of at least one member of the group consisting of an alkali metal or an alkaline earth metal inorganic base, an ammonium alkali metal or alkaline earth metal salt of an organic carboxylic acid and ammonium carbonate. The starting N-protected aspartic anhydride, e.g., N-benzyloxycarbonyl-L-aspartic anhydride, can be produced by the reaction of N-protected aspartic acid with phosgene. When the N-protecting group sibenzyloxycarbonyl and the solvent is acetic acid, the desired product can be isolated from the reaction mixture in crystalline form in high purity by adding water thereto.

    摘要翻译： 公开了一种由N-保护的L-天冬氨酸酐和L-苯丙氨酸甲酯制备N-保护的α-L-天冬氨酰-L-苯丙氨酸甲酯的改进方法，其改进包括使用L-苯丙氨酸甲酯 酯，其为无机酸盐，并且在有机溶剂中和有机羧酸的盐存在下进行反应，或（b）在包含有机羧酸的有机溶剂中和 存在由碱金属或碱土金属无机碱组成的组中的至少一种，有机羧酸的铵碱金属或碱土金属盐和碳酸铵。 起始的N-保护的天冬氨酸酐，例如N-苄氧基羰基-L-天冬氨酸酐可以通过N-保护的天冬氨酸与光气的反应来制备。 当N-保护基团苄氧基羰基和溶剂为乙酸时，可以通过向其中加入水从所述反应混合物中以高纯度从结晶形式中分离所需产物。

    Process for producing N-acylphenylalanines
    7.
    发明授权
    Process for producing N-acylphenylalanines 失效
    N-酰基苯丙氨酸的制备方法

    公开(公告)号：US4612388A

    公开(公告)日：1986-09-16

    申请号：US719300

    申请日：1985-04-03

    申请人： Ryuichi Mita ,  Toshio Katoh ,  Chojiro Higuchi ,  Akihiro Yamaguchi

    发明人： Ryuichi Mita ,  Toshio Katoh ,  Chojiro Higuchi ,  Akihiro Yamaguchi

    IPC分类号： C07C231/10 ,  C07C67/00 ,  C07C231/00 ,  C07C231/12 ,  C07C233/46 ,  C07C233/47 ,  C07C233/82 ,  C07C233/83 ,  C07C99/06

    CPC分类号： C07C233/46

    摘要： Disclosed herein is a process for producing an N-acyl-substituted or unsubstituted phenylalanine comprising hydrolyzing a 2-substituted-4-substituted or unsubstituted benzylidene-5-oxazolone with alkali, adjusting pH of the reaction solution containing its hydrolysis product with acid at 5-9 and reducing the resultant reaction solution catalytically in the presence of a palladium or platinum reducing catalyst.In accordance with the process of the present invention, time duration required for effecting the reduction can be shortened markedly in comparison with the reduction in an aqueous strong alkaline solution. Moreover, the catalyst recovered after completion of the reduction can be used repeatedly without any additional treatment and without any observed lowering in its activity. Accordingly, the reduction using the recovered catalyst may proceed in practically the same time as in the case of using a fresh catalyst.In the process of the present invention, the reduction is carried out continuously without isolating the alkaline hydrolysis product, i.e., a substituted or unsubstituted N-acylaminocinnamic acid from the reaction mixture, so that the process is featured advantageously by simplified process and improved overall yield.

    摘要翻译： 本文公开了N-酰基取代或未取代的苯丙氨酸的制备方法，其包括用碱水解2-取代-4-取代或未取代的亚苄基-5-恶唑酮，调节含有其水解产物的反应溶液的pH为5 -9并在钯或铂还原催化剂的存在下催化还原所得的反应溶液。 根据本发明的方法，与强碱性水溶液的降低相比，可以显着缩短实现还原所需的时间。 此外，还原后还原反应的催化剂可以重复使用，无需任何额外的处理，并且没有观察到其活性降低。 因此，使用回收的催化剂的还原可以与使用新鲜催化剂的情况几乎相同的时间进行。 在本发明的方法中，还原是从反应混合物中分离碱性水解产物，即取代或未取代的N-酰氨基肉桂酸，连续进行，使得该方法有利地通过简化的方法和改进的总产率 。

    Method for electrically insulating an electrically conducting article and product produced thereby
    8.
    发明授权
    Method for electrically insulating an electrically conducting article and product produced thereby 失效
    用于电绝缘导电制品的方法和由此产生的产品

    公开(公告)号：US4239998A

    公开(公告)日：1980-12-16

    申请号：US886422

    申请日：1978-03-14

    申请人： Takeshi Hakamada ,  Hideyo Hirata ,  Toshio Katoh

    发明人： Takeshi Hakamada ,  Hideyo Hirata ,  Toshio Katoh

    IPC分类号： H01F27/32 ,  H02K3/32 ,  H02K15/12 ,  H01B7/00 ,  H01F27/30

    CPC分类号： H01F27/323 ,  H02K3/325 ,  Y10T428/251

    摘要： A method for producing electrically insulated apparatus, which may be used in windings for rotary electric machines, for example, an induction motor, synchronous machines, DC machines or stationary induction apparatus, for example, transformers, and the product produced thereby comprising an electric conductor and an insulating layer formed around the electric conductor, wherein said insulating layer contains a resin having excellent permeability for the gas generated in the layer, e.g., a silicone resin, and a resin having excellent adhesive force in an appropriate blending ratio in order to impart excellent thermal resistance to the electrically insulated apparatus.

    摘要翻译： 可用于旋转电机的绕组中的电绝缘装置的方法，例如感应电动机，同步电动机，直流电机或固定式感应装置，例如变压器，由此生产的产品包括电导体 以及形成在所述导电体周围的绝缘层，其中所述绝缘层包含对于在所述层中产生的气体例如硅树脂和具有优异的粘合力的树脂在适当的混合比例中具有优异渗透性的树脂，以赋予 对电绝缘装置具有优异的耐热性。

    Production process of cross-linked polysuccinimide resin
    9.
    发明授权
    Production process of cross-linked polysuccinimide resin 有权
    交联聚琥珀酰亚胺树脂的生产工艺

    公开(公告)号：US06346569B1

    公开(公告)日：2002-02-12

    申请号：US09514954

    申请日：2000-02-28

    申请人： Yoshihiro Irizato ,  Makoto Sukegawa ,  Toshio Katoh ,  Hiroaki Tamatani ,  Akinori Nagatomo ,  Masaru Wada

    发明人： Yoshihiro Irizato ,  Makoto Sukegawa ,  Toshio Katoh ,  Hiroaki Tamatani ,  Akinori Nagatomo ,  Masaru Wada

    IPC分类号： C08J324

    CPC分类号： C08G73/1092

    摘要： A process is disclosed for producing with good productivity a cross-linked polyaspartic acid resin having biodegradability and high water absorbency. The process features inclusion of one of the following steps: (a) a polysuccinimide, which has been brought into a dispersed state by a dispersant, and a cross-linking agent are reacted to produce the cross-linked polyaspartic acid resin; (b) imide rings of a cross-linked polysuccinimide are subjected to a hydrolysis reaction while controlling a swelling degree of a resulting gel, whereby the cross-linked polyaspartic acid resin is produced; and (c) a gel of a cross-linked polysuccinimide, which has been obtained by reacting a cross-linking agent to a solution of a polysuccinimide in an organic solvent, is disintegrated to subject imide rings of the cross-linked polysuccinimide to a hydrolysis reaction, so that the cross-linked polyaspartic acid resin is produced. The process may also include one or both of the following steps as needed: (d) a gel of the cross-linked polyaspartic acid resin is washed with water and/or a water-miscible organic solvent; and (e) the polysuccinimide is produced using a basic amino acid as a cross-linking agent.

    摘要翻译： 公开了一种具有生物降解性和高吸水性的交联聚天冬氨酸树脂以高生产率生产的方法。 该方法包括以下步骤之一：（a）已经通过分散剂进入分散状态的聚琥珀酰亚胺和交联剂反应生成交联聚天冬氨酸树脂; （b）交联聚琥珀酰亚胺的酰亚胺环进行水解反应同时控制所得凝胶的溶胀度，从而制得交联聚天冬氨酸树脂; 和（c）通过使交联剂与聚琥珀酰亚胺在有机溶剂中的溶液反应而获得的交联聚琥珀酰亚胺的凝胶被分解以使交联的聚琥珀酰亚胺的酰亚胺环进行水解 反应，制成交联聚天冬氨酸树脂。 该方法还可以根据需要包括以下步骤中的一种或两种：（d）用水和/或水混溶性有机溶剂洗涤交联聚天冬氨酸树脂的凝胶; 和（e）使用碱性氨基酸作为交联剂制备聚琥珀酰亚胺。