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    Anti-VEGF human monoclonal antibody
    1.
    发明授权
    Anti-VEGF human monoclonal antibody 失效
    抗VEGF人单克隆抗体

    公开(公告)号：US5730977A

    公开(公告)日：1998-03-24

    申请号：US698041

    申请日：1996-08-15

    申请人： Hisayoshi Ooka ,  Shiro Takagi ,  Izumi Mita ,  Noboru Satozawa ,  Ayako Watanabe ,  Tomoko Yokomatsu

    发明人： Hisayoshi Ooka ,  Shiro Takagi ,  Izumi Mita ,  Noboru Satozawa ,  Ayako Watanabe ,  Tomoko Yokomatsu

    IPC分类号： A61K38/00 ,  C07K16/22 ,  C12N5/24 ,  A61K39/395 ,  C12N5/00 ,  C12P21/08

    CPC分类号： C07K16/22 ,  A61K38/00

    摘要： The present invention provides an anti-VEGF human monoclonal antibody capable of binding to human VEGF to neutralize its activity, a cell strain producing said human monoclonal antibody, and a vascularization inhibitor containing said human monoclonal antibody. Hybridoma strains VA01 and BL2 producing the anti-VEGF human monoclonal antibody can also be provided according to the present invention by transformation with Epstein-Barr Virus (EBV) of human lymphocyte producing anti-human VEGF antibody and then fusing the transformant cells with human myeloma cells. The monoclonal antibody of the present invention can serve as a vascularization inhibitor which is useful for human because it is derived from human and capable of binding specifically to VEGF participating in vascularization, to inhibit the migration or proliferation of vascular endothelial cells.

    摘要翻译： 本发明提供能够结合人VEGF以中和其活性的抗VEGF人单克隆抗体，产生所述人单克隆抗体的细胞株和含有所述人单克隆抗体的血管抑制剂。 也可以通过用产生人淋巴细胞的抗人VEGF抗体的爱泼斯坦 - 巴尔病毒（EBV）进行转化，然后将转化体细胞与人骨髓瘤融合，根据本发明提供产生抗VEGF人单克隆抗体的杂交瘤菌株VA01和BL2 细胞。 本发明的单克隆抗体可用作血管抑制剂，其可用于人，因为其衍生自人并能够特异性结合参与血管形成的VEGF，以抑制血管内皮细胞的迁移或增殖。

    Anti-mesothelin antibodies and uses thereof
    3.
    发明授权
    Anti-mesothelin antibodies and uses thereof 有权
    抗间皮素抗体及其用途

    公开(公告)号：US09023351B2

    公开(公告)日：2015-05-05

    申请号：US12744849

    申请日：2008-11-19

    申请人： Antje Kahnert ,  David Light ,  Doug Schneider ,  Renate Parry ,  Noboru Satozawa ,  Tara Renee Heitner Hansen ,  Stefan Steidl ,  Ulrike Schubert

    发明人： Antje Kahnert ,  David Light ,  Doug Schneider ,  Renate Parry ,  Noboru Satozawa ,  Tara Renee Heitner Hansen ,  Stefan Steidl ,  Ulrike Schubert

    IPC分类号： C12P21/08 ,  C07K16/30

    CPC分类号： C07K16/30 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/77 ,  C07K2317/92

    摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 4O.kDa mesothelin polypeptide, which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of mesothelin in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

    摘要翻译： 本发明提供了重组抗原结合区和含有这样的抗原结合区的抗体和功能片段，所述抗原结合区对于多个肿瘤如胰腺和卵巢肿瘤间皮瘤中过表达的膜锚定的40kDa的间皮素多肽是特异性的 和肺癌细胞。 因此，这些抗体可用于治疗这些和其他病症和病症。 本发明的抗体也可用于诊断领域，以及进一步研究间皮素在与癌症相关疾病进展中的作用。 本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。