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公开(公告)号：US4942172A
公开(公告)日：1990-07-17
申请号：US196431
申请日：1988-05-20
IPC分类号： C07D339/06 , A61K31/385 , A61P1/16
CPC分类号： A61K31/385 , Y10S514/894
摘要： A method of curing or alleviating hepatic disease comprising administrating to the patient 1,3-dithiole-2-thione or 1,3-dithiolane-2-thione is disclosed. Adminstration of the compound can be made in various dosing forms, including tablets, granules, powders, capsules, suspensions, injections, and suppositories. Normal dosing amount can be determined from the range of 0.01 to 50 mg/kg/day for oral administration, and 0.002 to 10 mg/kg/day for injection or other forms of administration.
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公开(公告)号：US4849512A
公开(公告)日：1989-07-18
申请号：US177483
申请日：1988-04-01
申请人： Minoru Tokizawa , Mari Otsuka , Kazuhiko Irinoda , Seiji Ishizeki , Fumio Ishii , Kenichi Kukita , Hideaki Matsuda , Tatsuhiko Katori
发明人： Minoru Tokizawa , Mari Otsuka , Kazuhiko Irinoda , Seiji Ishizeki , Fumio Ishii , Kenichi Kukita , Hideaki Matsuda , Tatsuhiko Katori
摘要： Derivatives of 3-acylamino-3-deoxyallose represented by the following formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen atoms, or R.sup.1 and R.sup.2, and R.sup.3 and R.sup.4 may be in combination an isopropylidene group, R.sup.5 represents a hydrogen atom or alkyl group, and R.sup.6 represents a hydrogen atom or acyl group, are disclosed. One of the typical compound 3-deoxy-3-(3-tetradecanoyloxytetradecanoylamino)-1,2:5,6-di-O-isopropylidene- .alpha.-D-allofuranose is prepared by reacting 3-tetradecanoyloxytetradecanoic acid and 3-amino-3-deoxy-1,2:5,6-di-O-isopropylidene-.alpha.-D-allofuranose in the presence of N,N'-dicyclohexylcarbodiimide, as a dehydrating agent. The compound has an excellent carcinostatic activity.
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公开(公告)号：US5008419A
公开(公告)日：1991-04-16
申请号：US451637
申请日：1989-12-18
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： A platinum complex having the following formula (I) is disclosed, ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represents a methyl group or an ethyl group, and the configuration of 1,2-diaminocyclohexane is either cis-, trans-l-, trans-d-, or trans-dl-.The compound possess excellent antitumor activity with a high therapeutic index and abundant water solubility, and thus are effective as an antitumor agent.
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公开(公告)号：US4968825A
公开(公告)日：1990-11-06
申请号：US418169
申请日：1989-10-06
申请人： Koichi Yokoi , Kinichi Mogi , Kazuhiko Irinoda , Hidehiko Kohya , Susumu Sato , Tatsuhiko Katori
发明人： Koichi Yokoi , Kinichi Mogi , Kazuhiko Irinoda , Hidehiko Kohya , Susumu Sato , Tatsuhiko Katori
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.
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公开(公告)号：US4904809A
公开(公告)日：1990-02-27
申请号：US245222
申请日：1988-09-16
申请人： Koichi Yokoi , Kinichi Mogi , Kazuhiko Irinoda , Hidehiko Kohya , Susumu Sato , Tatsuhiko Katori
发明人： Koichi Yokoi , Kinichi Mogi , Kazuhiko Irinoda , Hidehiko Kohya , Susumu Sato , Tatsuhiko Katori
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.
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